The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: Accuracy improvement

Current Drug Metabolism

Volumn 9, Issue 1, 2008, Pages 39-45

  Li, Peng ^a,c   Wang, Guang Ji ^a   Li, Jing ^b   Zhang, Qian ^a   Liu, Xin ^c   Khlentzos, Alexander ^c   Roberts, Michael S ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU UNIVERSITY   (China)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Clearance prediction; Enzyme kinetics; Metabolism; Tanshinone IIA

Indexed keywords

DIAZEPAM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TANSHINONE; TANSHINONE 2A; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; CELL FRACTIONATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME KINETICS; IN VIVO STUDY; LIVER CLEARANCE; LIVER CYTOSOL; LIVER MICROSOME; NONHUMAN; PREDICTION; RAT; REVIEW;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; INJECTIONS, INTRAVENOUS; LIVER; MASS SPECTROMETRY; METABOLIC CLEARANCE RATE; MICROSOMES, LIVER; MODELS, BIOLOGICAL; NAD; NADP; PHENANTHRENES; PREDICTIVE VALUE OF TESTS; RATS; REPRODUCIBILITY OF RESULTS; SUBCELLULAR FRACTIONS; URIDINE DIPHOSPHATE GLUCURONIC ACID;

EID: 38849199135     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008783331103     Document Type: Review

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