Gender-specific vascular effects elicited by chronic ethanol consumption in rats: A role for inducible nitric oxide synthase

British Journal of Pharmacology

Volumn 153, Issue 3, 2008, Pages 468-479

  Tirapelli, C R ^a   Fukada, S Y ^a   Yogi, A ^a   Chignalia, A Z ^a   Tostes, R C ^a   Bonaventura, D ^a   Lanchote, V L ^a   Cunha, F Q ^a   De Oliveira, A M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aorta; Ethanol consumption; Gender; Inducible nitric oxide synthase; Nitric oxide

Indexed keywords

7 NITROINDAZOLE; ACETYLCHOLINE; ALCOHOL; AMINOGUANIDINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; PHENYLEPHRINE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; ENDOTHELIUM; ENZYME ACTIVITY; FEMALE; HEART CONTRACTION; HEART MUSCLE RELAXATION; MALE; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SEX DIFFERENCE; THORACIC AORTA; UPREGULATION; VASCULAR RING; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA, THORACIC; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ENDOTHELIUM, VASCULAR; ETHANOL; FEMALE; MALE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OVARIECTOMY; RATS; RATS, WISTAR; RNA, MESSENGER; SEX FACTORS; UP-REGULATION; VASOCONSTRICTION; VASODILATION;

EID: 38849176921     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707589     Document Type: Article

References (47)

1. Altura BM, Altura BT (1982). Microvascular and vascular smooth muscle actions of ethanol, acetaldehyde, and acetate. Fed Proc 41: 2447-2451.
2. Budec M, Koko V, Milovanovic T, Balint-Peric L, Petkovic A (2002). Acute ethanol increases level of progesterone in ovariectomized rats. Alcohol 26: 173-178.
3. Budec M, Trtic T, Balint-Peric L, Bugarski D (1996). Increased levels of progesterone in rats following acute ethanol treatment. Acta Vet 46: 293-298.
4. Castillo C, Ariznavarreta MC, Lahera V, Cachofeiro V, Gil-Loyzaga P, Tresguerres JA (2005). Effects of ovariectomy and growth hormone administration on body composition and vascular function and structure in old female rats. Biogerontology 6: 49-60.
5. Chan TC, Sutter MC (1983). Ethanol consumption and blood pressure. Life Sci 33: 1965-1973.
6. Chinellato A, Froldi G, Caparrotta L, Ragazzi E (1998). Pharmacological characterization of endothelial cell nitric oxide synthase inhibitors in isolated rabbit aorta. Life Sci 62: 479-490.
7. Cohen ML, Susemichel AD (1996). Effects of 17 β-estradiol and the nonsteroidal benzothiophene, LY117018 on in vitro rat aortic responses to norepinephrine, serotonin, U46619 and BAYK 8644. Drug Dev Res 37: 97-104.
8. 2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol 26: 707-715.
9. El-Mas MM, Abdel-Rahman AA (1999). Oestrogen-dependent hypotensive effects of ethanol in conscious female rats. Alcohol Clin Exp Res 23: 624-632.
10. El-Mas MM, Zhang J, Abdel-Rahman AA (2006). Upregulation of vascular inducible nitric oxide synthase mediates the hypotensive effect of ethanol in conscious female rats. J Appl Physiol 100: 1011-1018.
11. Forstermann U, Boissel JP, Kleinert H (1998). Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12: 773-790.
12. Fortmann SP, Haskell WL, Vranizan K, Brown BW, Farquhar JW (1983). The association of blood pressure and dietary alcohol: differences by age, sex, and oestrogen use. Am J Epidemiol 118: 497-507.
13. Freeman ME (1994). The neuroendrocrine control of ovarian cycle of the rat. In: Knobil E, Neil JD (eds). The Physiology of Reproduction. Raven Press Ltd: New York. pp 613-658.
14. Fukada SY, Iyomasa MM, Cunha FQ, Correa FM, de Oliveira AM (2004). Mechanisms of impaired vascular response to ANG II in perivascular injured carotid arteries of ovariectomized rat. J Cardiovasc Pharmacol 44: 393-400.
15. Gavaler JS, Rosenblum ER (1987). Exposure-dependent effects of ethanol administered in drinking water on serum estradiol and uterus mass in sexually mature oophorectomized rats: a rat model for bilaterally ovariectomized/ postmenopausal women. J Stud Alcohol 48: 295-303.
16. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G (1992). Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci USA 89: 11259-11263.
17. 2+ removal upon vascular smooth muscle contraction induced by noripenephrine, histamine and potassium. J Pharm Exp Ther 159: 91-97.
18. Isobe H, Okajima K, Uchiba M, Mizutani A, Harada N, Nagasaki A et al. (2001). Activated pretein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide. Circulation 104: 1171-1175.
19. G-methyl-L-arginine, and aminoguanidine on constitutive and inducible nitric oxide synthase in rat aorta. Biochem Biophys Res Commun 199: 147-154.
20. Kahonen M, Karjala K, Hutri-Kahonen N, Wu X, Jaatinen P, Riihioja P et al. (1999). Influence of chronic ethanol consumption on arterial tone in young and aged rats. Am J Physiol 276 (2 Part 2): H464-H471.
21. Karaa A, Kamoun WS, Clemens MG (2005). Chronic ethanol sensitizes the liver to endotoxin via effects on endothelial nitric oxide synthase regulation. Shock 24: 447-454.
22. Khisty RT, Kumar S, Morrow AL (2003). Ethanol rapidly induces steroidogenic acute regulatory protein expression and translocation in rat adrenal gland. Eur J Pharmacol 473: 223-225.
23. Klatsky AL, Friedman GD, Armstrong MA (1986). The relationships between alcoholic beverage use and other traits to blood pressure: a new Kaiser Permanent study. Circulation 73: 628-636.
24. Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA et al. (2000). Gender differences in early alcohol-induced liver injury: role of CD14, NF-κB, and TNFα. Am J Physiol Gastrointest Liver Physiol 278: G625-G661.
25. Krecsmarik M, Izbeki F, Bagyanszki M, Linke N, Bodi N, Kaszaki J et al. (2006). Chronic ethanol exposure impairs neuronal nitric oxide synthase in the rat intestine. Alcohol Clin Exp Res 30: 967-973.
26. MacRitchie AN, Jun SS, Chen Z, German Z, Yuhanna IS, Sherman TS et al. (1997). Oestrogen up regulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res 81: 355-362.
27. Manolio TA, Levy D, Garrison RJ, Castelli WP, Kannel WB (1991). Relation of alcohol intake to left ventricular mass: the Framingham study. J Am Coll Cardiol 17: 717-721.
28. Montes GS, Luque EH (1988). Effects of ovarian steroids on vaginal smears in the rat. Acta Anat (Basel) 133: 192-199.
29. Moore RD, Levine DM, Southard J, Entwisle G, Shapiro S (1990). Alcohol consumption and blood pressure in the 1982 Maryland hypertension survey. Am J Hypertens 3: 1-7.
30. Nuedling S, Kahlert S, Loebbert K, Doevendans PA, Meyer R, Vetter H et al. (1999). 17 Beta-estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium in-vitro and in-vivo. Cardiovasc Res 43: 666-674.
31. Rees DD, Palmer RM, Schulz R, Hodson HF, Moncada S (1990). Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101: 746-752.
32. Resstel LB, Tirapelli CR, Lanchote VL, Uyemura SA, de Oliveira AM (2006). Chronic ethanol consumption alters cardiovascular functions in conscious rats. Life Sci 78: 2179-2187.
33. Selles J, Polini N, Alvarez C, Massheimer V (2002). Nongenomic action of progesterone in rat aorta: role of nitric oxide and prostaglandins. Cell Signal 14: 431-436.
34. Srivastava VK, Hiney JK, Rettori V, Dees WL (1999). Effects of ethanol on intraovarian nitric oxide production in the prepubertal rat. J Endocrinol 161: 69-75.
35. Stewart CW, Kennedy RH (1999). Effects of chronic ethanol consumption on aortic constriction in male and female rats. Eur J Pharmacol 366: 55-60.
36. Strickland JA, Wooles WR (1988). Effect of acute and chronic ethanol on the agonist responses of vascular smooth muscle. Eur J Pharmacol 152: 83-91.
37. Subbiah MT, Kessel B, Agrawal M, Rajan R, Abplanalp W, Rymaszevisk Z (1993). Antioxidant potential of specific oestrogens on lipid peroxidation. J Clin Endocrinol Metab 77: 1095-1097.
38. Sun H, Mayhan WG (2005). Sex difference in nitric oxide synthase-dependent dilatation of cerebral arterioles during long-term alcohol consumption. Alcohol Clin Exp Res 29: 430-436.
39. Thompson J, Khalil RA (2003). Gender differences in the regulation of vascular tone. Clin Exp Pharmacol Physiol 30: 1-15.
40. Tirapelli CR, Al-Khoury J, Bkaily G, D'Orleans-Juste P, Lanchote VL, Uyemura SA et al. (2006a). Chronic ethanol consumption enhances phenylephrine-induced contraction in the isolated rat aorta. J Pharmacol Exp Ther 316: 233-241.
41. Tirapelli CR, Casolari DA, Montezano AC, Yogi A, Tostes RC, Legros E et al. (2006b). Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid. J Pharmacol Exp Ther 318: 819-827.
42. Tirapelli CR, Leone FCA, Coelho EB, Resstel LB, Corrêa FMA, Lanchote VL et al. (2007). Effect of ethanol consumption on blood pressure and rat mesenteric arterial bed, aorta and carotid responsiveness. J Pharm Pharmacol 59: 985-993.
43. Tokuno S, Chen F, Pernow J, Jiang J, Valen G (2002). Effects of spontaneous or induced brain ischemia on vessel reactivity: the role of inducible nitric oxide synthase. Life Sci 71: 679-692.
44. Utkan T, Yildiz F, Ilbay G, Ozdemirci S, Erden BF, Gacar N et al. (2001). Blood pressure and vascular reactivity to endothelin-1, phenylephrine, serotonin, KCl and acetylcholine following chronic alcohol consumption in vitro. Fundam Clin Pharmacol 15: 157-165.
45. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S (1994). Induction of calcium-dependent nitric oxide syntheses by sex hormones. Proc Natl Acad Sci USA 91: 5212-5216.
46. Yuan GJ, Zhou XR, Gong ZJ, Zhang P, Sun XM, Zheng SH (2006). Expression and activity of inducible nitric oxide synthase and endothelial nitric oxide synthase correlate with ethanol-induced liver injury. World J Gastroenterol 12: 2375-2381.
47. Zhang M, Wang GJ, Benishin CG, Pang PKT (2002). Rapid effect of progesterone on the contraction of rat aorta in-vitro. J Pharm Pharmacol 54: 1529-1534.