Self RNA cleavage by RNAse L amplifies antiviral innate immunity;Cliver les ARN du soi donne du punch à la réponse innée antivirale

Medecine/Sciences

Volumn 24, Issue 1, 2008, Pages 23-25

  Bisbal, Catherine ^a  

^a HÔPITAL ARNAUD DE VILLENEUVE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 5A SYNTHETASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYXOVIRUS RESISTANCE PROTEIN; PROTEIN KINASE R; RETINOIC ACID INDUCIBLE PROTEIN I; RIBONUCLEASE; SYNTHETASE; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; GENE AMPLIFICATION; INNATE IMMUNITY; NOTE; RNA CLEAVAGE; VIRUS INFECTION;

EID: 38849122710     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/200824123     Document Type: Note

References (13)

1. Isaacs A, Lindenmann J. Virus Interference. I. The Interferon. Proc R Soc Lond B Biol Sci 1957 ; 147 : 258-67.
2. Stetson DB, Medzhitov R. Type I interferons in host defense. Immunity 2006 ; 25 : 373-81.
3. Georgel P, Bahram S. Immunité innée antivirale : rôle des mécanismes Toll-dépendants. Med Sci (Paris) 2006 ; 22 : 961-8.
4. Delneste Y, Beauvillain C, Jeannin P. Immunité naturelle : structure et fonction des Toll-like receptors. Med Sci (Paris) 2007 ; 23 : 67-73.
5. Pichimair A, Schulz O, Tan CP, et al. RIG-1-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 2006 ; 314 : 997-1001.
6. Hornung V, Ellegast J, Kim S, et al. 5′-Triphosphate RNA is the ligand for RIG-I. Science 2006 ; 314 : 994-7.
7. Marques JT, Devosse T, Wang D, et al. A structural basis for discriminating between seif and nonself double-stranded RNAs in mammalian cells. Nat Biotechnol 2006 ; 24 : 559-65.
8. Malathi K, Dong B, Gale M Jr, et al. Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 2007 ; 448 : 816-9.
9. Bisbal C, Martinand C, Silhol M, et al. Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J Biol Chem 1995 ; 270 : 13308-17.
10. Martinand C, Montavon C, Salehzada T, et al. RNase L inhibitor is induced during human immunodeficiency virus type 1 infection and down regulates the 2-5A/RNase L pathway in human T cells. J Virol 1999 ; 73 : 290-6.
11. Coulombel L. Lignes Maginot antivirales. Med Sci (Paris) 2006 ; 22 : 1049.
12. Katze MG, He Y, Gale M. Viruses and interferon: a fight for supremacy. Nat Rev Immunol 2002 ; 2 : 675-87.
13. Xiang Y, Condit RC, Vijaysri S, et al. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol 2002 ; 76 : 5251-9.