Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1431-1443

  Martini, Elisabetta ^a   Ghelardini, Carla ^b   Dei, Silvia ^a   Guandalini, Luca ^a   Manetti, Dina ^a   Melchiorre, Michele ^a   Norcini, Monica ^b   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Romanelli, Maria Novella ^a  

^a Laboratory of Design   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Cognition enhancers; Mild cognitive impairment; Mouse passive avoidance test; Sunifiram

Indexed keywords

DM 235; MN 19; NOOTROPIC AGENT; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; SAPUNIFIRAM; SCOPOLAMINE; SUNIFIRAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; MOUSE; NONHUMAN; PASSIVE AVOIDANCE; STRUCTURE ACTIVITY RELATION;

ACYLATION; ANIMALS; COGNITION; DRUG DESIGN; MICE; MOLECULAR STRUCTURE; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR;

EID: 38849097812     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.050     Document Type: Article

References (30)

1. Ganguli M. Alzheimer Dis. Assoc. Disord. 20 (2006) S52
2. Busse A., Hensel A., Gühne U., Angermeyer M.C., and Riedel-Heller S.G. Neurology 67 (2006) 2176
3. Levey A., Lah J., Goldstein F., Steenland K., and Bliwise D. Clin. Ther. 28 (2006) 991
4. Jelic V., Kivipelto M., and Winblad B. J. Neurol. Neurosurg. Psychiatry 77 (2006) 429
5. Gualtieri F., Guandalini L., Manetti D., Martini E., and Romanelli M.N. Med. Chem. Rev. (Online) 2 (2005) 471
6. Gualtieri F., Manetti D., Romanelli M.N., and Ghelardini C. Curr. Pharm. Des. 8 (2002) 125
7. Moriguchi S., Shioda N., Maejima H., Zhao X., Marszalec W., Yeh J.Z., Fukunaga K., and Narahashi T. Mol. Pharmacol. 71 (2007) 580
8. Zhao X., Kuryatov A., Lindstrom J.M., Yeh J.Z., and Narahashi T. Mol. Pharmacol. 59 (2001) 674
9. Manetti D., Ghelardini C., Bartolini A., Bellucci C., Dei S., Galeotti N., Gualtieri F., Romanelli M.N., Scapecchi S., and Teodori E. J. Med. Chem. 43 (2000) 1969
10. Manetti D., Ghelardini C., Bartolini A., Dei S., Galeotti N., Gualtieri F., Romanelli M.N., and Teodori E. J. Med. Chem. 43 (2000) 4499
11. Romanelli M.N., Galeotti N., Ghelardini C., Manetti D., Martini E., and Gualtieri F. CNS Drug Rev. 12 (2006) 39
12. Galeotti N., Ghelardini C., Pittaluga A., Pugliese A.M., Bartolini A., Manetti D., Romanelli M.N., and Gualtieri F. Naunyn-Schmiedeberg's Arch. Pharmacol. 368 (2003) 538
13. Manetti D., Martini E., Ghelardini C., Dei S., Galeotti N., Guandalini L., Romanelli M.N., Scapecchi S., Teodori E., and Gualtieri F. Bioorg. Med. Chem. Lett. 13 (2003) 2303
14. Kane J.M., and Carr A.A. Tetrahedron Lett. 21 (1980) 3019
15. Choi S.-W., Elmaleh D.R., Hanson R.N., and Fischman A.J. J. Med. Chem. 42 (1999) 3647
16. Bernotas R.C., and Adams G. Tetrahedron Lett. 37 (1996) 7339
17. Saikawa, I.; Takano, S.; Yoshida, C.; Takashima, O.; Momonoi, K.; Kuroda, S.; Komatsu, M.; Yasuda, T.; Kodama, Y. Ger. Offen. DE 2519400 1976. Chem. Abstr. 1976, 85, 33052.
18. Cumming, J. N.; Huang, Y.; Li, G.; Iserloh, U.; Stamford, A.; Strickland, C.; Voigt, J. H.; Wu, Y.; Pan, J.; Guo, T.; Hobbs, D. W.; Le, T. X. H.; Lowrie, J. F. WO 2005014540, 2005. Chem. Abstr. 2005, 142, 240330.
19. Struve G.E., Gazzola C., and Kenyon G.L. J. Org. Chem. 42 (1977) 4035
20. Huang W., Naughton M.A., Yang H., Su T., Dam S., Wong P.W., Arfsten A., Edwards S., Sinha U., Hollenbach S., Scarborough R.M., and Zhu B.-Y. Bioorg. Med. Chem. Lett. 13 (2003) 723
21. Carceller E., Merlos M., Giral M., Balsa D., Garcia-Rafanell J., and Forn J. J. Med. Chem. 39 (1996) 487
22. Caldwell, C.; Chapman, K.; Hale, J.; Kim, D.; Lynch, C.; Maccoss, M.; Mills, S. G.; Willoughby, C.; Berk, S.; Kim, R. M. WO 2000059498, 2000. Chem. Abstr. 2000, 133, 296373.
23. de Costa B.R., Dominguez C., He X.-S., Williams W., Radesca L., and Bowen W. J. Med. Chem. 35 (1992) 4334
24. Dener J.M., Wang V.R., Rice K.D., Gangloff A.R., Kuo E.Y.-L., Newcomb W.S., Putnamand D., and Wong M. Bioorg. Med. Chem. Lett. 11 (2001) 2325
25. Jarvik M.E., and Kopp R. Psychol. Rep. 21 (1967) 221
26. Scapecchi S., Martini E., Manetti D., Ghelardini C., Martelli C., Dei S., Galeotti N., Guandalini L., Romanelli M.N., and Teodori E. Bioorg. Med. Chem. 12 (2004) 71
27. Beshore D.C., and Dinsmore C.J. Org. Lett. 4 (2002) 1201
28. Saikawa I., Takano S., Yoshida C., Takashima O., Momonoi K., Yasuda T., and Kasuya K. Yakugaku Zasshi 97 (1977) 883
29. Chan, C.; Hamblin, J. N.; Kelly, H. A.; King, N. P.; Mason, A. M.; Patel, V. K.; Senger, S.; Shah, G. P.; Watson, N. S.; Weston, H. E.; Whitworth, C.; Young, R. J. WO 20020606, 2002. Chem. Abstr. 2002, 138, 39538.
30. Ackermann, J.; Banner, D.; Gubernator, K.; Hilpert, K.; Schmid, G. EP 559046, 1993. Chem. Abstr. 1993, 121, 83062.