-
4
-
-
0001396121
-
-
(d) Valls, N.; Segarra, V. M.; Bosch, J. Heterocycles 1986, 24, 943.
-
(1986)
Heterocycles
, vol.24
, pp. 943
-
-
Valls, N.1
Segarra, V.M.2
Bosch, J.3
-
5
-
-
0028932236
-
-
(e) Askew, B. C.; McIntyre, C. J.; Hunt, C. A.; Claremon, D. A.; Gould, R. J.; Lynch, R. J.; Armstrong, D. J. J. Bioorg. Med. Chem. Lett. 1995, 5, 475.
-
(1995)
J. Bioorg. Med. Chem. Lett.
, vol.5
, pp. 475
-
-
Askew, B.C.1
McIntyre, C.J.2
Hunt, C.A.3
Claremon, D.A.4
Gould, R.J.5
Lynch, R.J.6
Armstrong, D.J.7
-
7
-
-
0000844109
-
-
Abdel-Magid, A. F.; Carson, K. G.; Harris, B. D.; Maryanoff, C. A.; Shah, R. D. J. Org. Chem. 1996, 61, 3849.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 3849
-
-
Abdel-Magid, A.F.1
Carson, K.G.2
Harris, B.D.3
Maryanoff, C.A.4
Shah, R.D.5
-
8
-
-
0042904115
-
-
note
-
In each example studied, rapid accumulation of 7 was followed by gradual formation of piperazinone 6, as assessed by LC/MS analysis. None of 8 was observed.
-
-
-
-
9
-
-
0034717002
-
-
For a review, see: Coltart, D. M. Tetrahedron 2000, 56, 3449.
-
(2000)
Tetrahedron
, vol.56
, pp. 3449
-
-
Coltart, D.M.1
-
10
-
-
0039050539
-
-
(a) Kramer, U.; Guggisberg, A.; Hesse, M.; Schmid, H. Angew. Chem. 1977, 89, 899.
-
(1977)
Angew. Chem.
, vol.89
, pp. 899
-
-
Kramer, U.1
Guggisberg, A.2
Hesse, M.3
Schmid, H.4
-
11
-
-
0029935457
-
-
(b) Doll, M. K.-H.; Guggisberg, A.; Hesse, M. Helv. Chim. Acta 1996, 79, 541.
-
(1996)
Helv. Chim. Acta
, vol.79
, pp. 541
-
-
Doll, M.K.-H.1
Guggisberg, A.2
Hesse, M.3
-
12
-
-
0042904114
-
-
note
-
4), filtered, and concentrated in vacuo. Purification by flash chromatography (0 to 50% EtOAc in DCM) provided piperazinone 6e as a colorless oil (153 mg, 86% yield). For full characterization of compounds described herein, see Supporting Information.
-
-
-
-
13
-
-
0041400932
-
-
note
-
Both the methanesulfonamide and toluenesulfonamide versions of amide 4 were prepared and subjected to the reaction conditions. After 120 h at 80°C, the only detectable product (LC/MS analysis) was the corresponding reductive amination product.
-
-
-
-
14
-
-
0028593790
-
-
(a) Wang, L.-B.; Yu, C.-Y.; Huang, Z.-T. Synthesis 1994, 12, 1441.
-
(1994)
Synthesis
, vol.12
, pp. 1441
-
-
Wang, L.-B.1
Yu, C.-Y.2
Huang, Z.-T.3
-
15
-
-
0011216697
-
-
(b) Armati, A.; De Ruggieri, P.; Rossi, E.; Stradi, R. Synthesis 1986, 7, 573.
-
(1986)
Synthesis
, vol.7
, pp. 573
-
-
Armati, A.1
De Ruggieri, P.2
Rossi, E.3
Stradi, R.4
-
16
-
-
0041901923
-
-
note
-
2 = Me) to give 12, followed by cyclization. Dehydration of 11 presumably relieves severe syn-pentane-like interactions (cf. Figure 1). matrix presented
-
-
-
-
17
-
-
0016403522
-
-
(a) Kemp, D. S.; Choong, S.-L. H.; Pekaar, J. J. Org. Chem. 1974, 39, 3841.
-
(1974)
J. Org. Chem.
, vol.39
, pp. 3841
-
-
Kemp, D.S.1
Choong, S.-L.H.2
Pekaar, J.3
-
18
-
-
0042403279
-
-
note
-
(a) Molecular modelling: conformations were generated using metric matrix distance geometry algorithm JG (S. Kearsley, Merck & Co., Inc., unpublished). Structures were subjected to energy minimization within the Macromodel program (ref 11b) using MMFF force field.
-
-
-
-
19
-
-
84986437005
-
-
(b) Mohamadi, F.; Richards, N. G. J.; Guida, W. C.; Liskamp, R.; Caufield, C.; Chang, G.; Hendrickson, T.; Still, W. C. J. Comput. Chem. 1990, 11, 440.
-
(1990)
J. Comput. Chem.
, vol.11
, pp. 440
-
-
Mohamadi, F.1
Richards, N.G.J.2
Guida, W.C.3
Liskamp, R.4
Caufield, C.5
Chang, G.6
Hendrickson, T.7
Still, W.C.8
-
20
-
-
0034754072
-
-
(a) Karp, J. E.; Kaufmann, S. H.; Adjei, A. A.; Lancet, J. E.; Wright, J. J.; End, D. W. Curr. Opin. Oncol 2001, 13, 470.
-
(2001)
Curr. Opin. Oncol
, vol.13
, pp. 470
-
-
Karp, J.E.1
Kaufmann, S.H.2
Adjei, A.A.3
Lancet, J.E.4
Wright, J.J.5
End, D.W.6
-
23
-
-
0035819989
-
-
(a) Dinsmore, C. J.; Bogusky, M. J.; Culberson, J. C.; Bergman, J. M.; Homnick, C. F.; Zartman, C. B.; Mosser, S. D.; Schaber, M. D.; Robinson, R. G.; Koblan, K. S.; Huber, H. E.; Graham, S. L.; Hartman, G. D.; Huff, J. R.; Williams, T. M. J. Am. Chem. Soc. 2001, 123, 2107.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 2107
-
-
Dinsmore, C.J.1
Bogusky, M.J.2
Culberson, J.C.3
Bergman, J.M.4
Homnick, C.F.5
Zartman, C.B.6
Mosser, S.D.7
Schaber, M.D.8
Robinson, R.G.9
Koblan, K.S.10
Huber, H.E.11
Graham, S.L.12
Hartman, G.D.13
Huff, J.R.14
Williams, T.M.15
-
24
-
-
0035932606
-
-
(b) Dinsmore, C. J.; Bergman, J. M.; Bogusky, M. J.; Culberson, J. C.; Hamilton, K. A. Graham, S. L. Org. Lett. 2001, 3, 865.
-
(2001)
Org. Lett.
, vol.3
, pp. 865
-
-
Dinsmore, C.J.1
Bergman, J.M.2
Bogusky, M.J.3
Culberson, J.C.4
Hamilton, K.A.5
Graham, S.L.6
-
25
-
-
0035952277
-
-
Dinsmore, C. J.; Bergman, J. M.; Wei, D. D.; Zartman, C. B.; Davide, J. P.; Greenberg, I. B.; Liu, D.; O'Neill, T. J.; Gibbs, J. B.; Koblan, K. S.; Kohl, N. E.; Lobell, R. B.; Chen, I.-W.; McLoughlin, D. A.; Olah, T. V.; Graham, S. L.; Hartman, G. D.; Williams, T. M. Bioorg. Med. Chem. Lett. 2001, 11, 537.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 537
-
-
Dinsmore, C.J.1
Bergman, J.M.2
Wei, D.D.3
Zartman, C.B.4
Davide, J.P.5
Greenberg, I.B.6
Liu, D.7
O'Neill, T.J.8
Gibbs, J.B.9
Koblan, K.S.10
Kohl, N.E.11
Lobell, R.B.12
Chen, I.-W.13
McLoughlin, D.A.14
Olah, T.V.15
Graham, S.L.16
Hartman, G.D.17
Williams, T.M.18
|