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Volumn 13, Issue 14, 2003, Pages 2303-2306

4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

Author keywords

[No Author keywords available]

Indexed keywords

NOOTROPIC AGENT; PIPERIDINE DERIVATIVE;

EID: 12444282300     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00437-2     Document Type: Article
Times cited : (24)

References (27)
  • 16
    • 85031145390 scopus 로고    scopus 로고
    • Eur. Pat. Appl. EP 625,507, 1994
    • Suedo, N. Eur. Pat. Appl. EP 625,507, 1994.
    • Suedo, N.1
  • 17
    • 85031146775 scopus 로고    scopus 로고
    • PCT Int. Appl. WO 0,042,011, 2000
    • Yamada, A.; Aoki, S. PCT Int. Appl. WO 0,042,011, 2000.
    • Yamada, A.1    Aoki, S.2
  • 19
    • 85031158157 scopus 로고    scopus 로고
    • Eur. Pat. Appl. EP 457,686, 1991
    • Peglion, J. L.; Colpaert, F. Eur. Pat. Appl. EP 457,686, 1991.
    • Peglion, J.L.1    Colpaert, F.2
  • 21
    • 85031147155 scopus 로고
    • US 3,124,586,1964
    • Zenitz, B. L. US 3,124,586,1964; Chem Abst. 1964, 61, 18188.
    • (1964) Chem Abst. , vol.61 , pp. 18188
    • Zenitz, B.L.1
  • 26
    • 85031146624 scopus 로고    scopus 로고
    • note
    • The apparatus for the passive avoidance test consists of a two-compartment acrylic box with a lighted compartment connected to a darkened one by a guillotine door. In the original method, mice received a punishing electrical shock as soon as they entered the dark compartment, while in our modified method, after entry into the dark compartment, mice receive a non-painful punishment consisting of a fall (from 40 cm) into a cold water bath (10°C). For this purpose, the dark chamber was constructed with a pitfall floor. The latency times for entering the dark compartment were measured in the training test (first day) and after 24 h in the retention test (second day). Mice who did not enter after 60 s latency were excluded from the experiment. For memory disruption, mice were ip injected with the amnesic drug scopolamine. All investigated drugs, dissolved in saline, were given ip 20 min before the training session, while amnesic drug was injected immediately after termination of the training session. The maximum entry latency allowed in the retention session was 120 s. The degree of received punishment memory (fall into cold water) was expressed as the increase in seconds between training and retention latencies.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.