Design, synthesis, and structure-activity relationship studies of novel 1-[(1-acyl-4-piperidyl)methyl]-1H-2-methylimidazo[4,5-c]pyridine derivatives as potent, orally active platelet-activating factor antagonists

Journal of Medicinal Chemistry

Volumn 39, Issue 2, 1996, Pages 487-493

  Carceller, Elena ^a   Merlos, Manuel ^a   Giral, Marta ^a   Balsa, Dolors ^a   García Rafanell, Julián ^a   Forn, Javier ^a  

^a Grupo Uriach   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[1 (3,3 DIPHENYLPROPIONYL) 4 PIPERIDYL]METHYL] 2 METHYL 1H IMIDAZO[4,5 C]PYRIDINE; 1 BENZHYDRYLAMINOMETHYLCARBONYL 4 (ALPHA CYANO 2 METHYL 3 PYRIDYLMETHYL)PIPERAZINE; APAFANT; IMIDAZOPYRIDINE DERIVATIVE; LEXIPAFANT; N METHYL N [4 [2 METHYL 1H IMIDAZO[4,5 C]PYRIDIN 1 YLMETHYL]PHENYLSULFONYL]LEUCINE ETHYL ESTER; PROPRANOLOL; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNCLASSIFIED DRUG; UR 12519; UR 12670;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HYPOTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MORTALITY; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RAT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

ANIMALS; DOGS; DRUG DESIGN; IMIDAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PLATELET ACTIVATING FACTOR; PLATELET AGGREGATION INHIBITORS; PYRIDINES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030070680     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950555i     Document Type: Article

References (17)

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