A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: The Multiethnic Cohort

BMC Medical Genetics

Volumn 8, Issue , 2007, Pages

  Lee, Sulggi A ^a   Haiman, Christopher A ^a   Burtt, Noel P ^c   Pooler, Loreall C ^a   Cheng, Iona ^g   Kolonel, Laurence N ^b   Pike, Malcolm C ^a   Altshuler, David ^c,d,e   Hirschhorn, Joel N ^c,d,f   Henderson, Brian E ^a   Stram, Daniel O ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROLACTIN; PROLACTIN RECEPTOR;

ADULT; ADVANCED CANCER; AFRICAN AMERICAN; AGED; ALLELE; ARTICLE; ASIAN AMERICAN; BLOOD SAMPLING; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; CAUCASIAN; COHORT ANALYSIS; CONTROLLED STUDY; ETHNIC GROUP; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CODE; GENETIC DATABASE; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HISPANIC; HOMOZYGOSITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; POSTMENOPAUSE; PREDICTION; PROLACTIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; BLOOD; BREAST TUMOR; ETHNOLOGY; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; RISK FACTOR;

ANIMALIA;

AFRICAN AMERICANS; AGED; ASIAN AMERICANS; BREAST NEOPLASMS; CASE-CONTROL STUDIES; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISPANIC AMERICANS; HUMANS; LINKAGE DISEQUILIBRIUM; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROLACTIN; RECEPTORS, PROLACTIN; RISK FACTORS;

EID: 38849090610     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-8-72     Document Type: Article

References (61)

1. Clevenger CV Furth PA Hankinson SE Schuler LA The role of prolactin in mammary carcinoma Endocr Rev 2003, 24:1-27 1698952 12588805 10.1210/ er.2001-0036
2. Yen SS Jaffe RB Reproductive endocrinology Philadelphia, PA, Saunders 4th edition 1999, 257-283
3. Muhlbock O Boot LM Induction of mammary cancer in mice without the mammary tumor agent by isografts of hypophyses. Cancer Res 1959, 19:402-412 13652125
4. Boot LM Muhlbock O Ropcke G Prolactin and the induction of mammary tumors in mice. General and Comparative Endocrinology 1962, 2:601-602
5. Welsch CW Gribler C Prophylaxis of spontaneously developing mammary carcinoma in C3H-HeJ female mice by suppression of prolactin Cancer Res 1973, 33:2939-2946 4795906
6. Welsch CW Nagasawa H Prolactin and murine mammary tumorigenesis: A review Cancer Res 1977, 37:951-963 191183
7. Liby K Neltner B Mohamet L Menchen L Ben-Jonathan N Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth Breast Cancer Res Treat 2003, 79:241-252 10.1023/A:1023956223037 12825859
8. Schroeder MD Symowicz J Schuler LA PRL modulates cell cycle regulators in mammary tumor epithelial cells Mol Endocrinol 2002, 16:45-57 10.1210/ me.16.1.45 11773438
9. Gutzman JH Miller KK Schuler LA Endogenous human prolactin and not exogenous human prolactin induces estrogen receptor alpha and prolactin receptor expression and increases estrogen responsiveness in breast cancer cells J Steroid Biochem Mol Biol 2004, 88:69-77 10.1016/ j.jsbmb.2003.10.008 15026085
10. Ormandy CJ Hall RE Manning DL Robertson JF Blamey RW Kelly PA Nicholson RI Sutherland RL Coexpression and cross-regulation of the prolactin receptor and sex steroid hormone receptors in breast cancer J Clin Endocrinol Metab 1997, 82:3692-3699 10.1210/jc.82.11.3692 9360527
11. Maus MV Reilly SC Clevenger CV Prolactin as a chemoattractant for human breast carcinoma Endocrinology 1999, 140:5447-5450 10.1210/ en.140.11.5447 10537179
12. Struman I Bentzien F Lee H Mainfroid V D'Angelo G Goffin V Weiner RI Martial JA Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: An efficient mechanism for the regulation of angiogenesis Proc Natl Acad Sci U S A 1999, 96:1246-1251 15448 9990009 10.1073/pnas.96.4.1246
13. Touraine P Martini JF Zafrani B Durand JC Labaille F Malet C Nicolas A Trivin C Postel-Vinay MC Kuttenn F Kelly PA Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues J Clin Endocrinol Metab 1998, 83:667-674 10.1210/jc.83.2.667 9467590
14. Ben-Jonathan N Liby K McFarland M Zinger M Prolactin as an autocrine/ paracrine growth factor in human cancer Trends Endocrinol Metab 2002, 13:245-250 10.1016/S1043-2760(02)00603-3 12128285
15. Clevenger CV Chang WP Ngo W Pasha TL Montone KT Tomaszewski JE Expression of prolactin and prolactin receptor in human breast carcinoma. Evidence for an autocrine/paracrine loop Am J Pathol 1995, 146:695-705 1869171 7534043
16. Tworoger SS Eliassen AH Rosner B Sluss P Hankinson SE Plasma prolactin concentrations and risk of postmenopausal breast cancer. Cancer Res 2004, 64:6814-6819 10.1158/0008-5472.CAN-04-1870 15375001
17. Manjer J Johansson R Berglund G Janzon L Kaaks R Agren A Lenner P Postmenopausal breast cancer risk in relation to sex steroid hormones, prolactin, and SHBG (Sweden). Cancer Causes Control 2003, 14:599-607 10.1023/A:1025671317220 14575357
18. Wang DY De Stavola BL Bulbrook RD Allen DS Kwa HG Fentiman IS Hayward JL Millis RR Relationship of blood prolactin levels and the risk of subsequent breast cancer Int J Epidemiol 1992, 21:214-221 10.1093/ije/ 21.2.214 1428472
19. Kabuto M Akiba S Stevens RG Neriishi K Land CE A prospective study of estradiol and breast cancer in Japanese women Cancer Epidemiol Biomarkers Prev 2000, 9:575-579 10868691
20. Cole EN England PC Sellwood RA Griffiths K Serum prolactin concentrations throughout the menstrual cycle of normal women and patients with recent breast cancer Eur J Cancer 1977, 13:677-684 598393
21. Malarkey WB Schroeder LL Stevens VC James AG Lanese RR Disordered nocturnal prolactin regulation in women with breast cancer Cancer Res 1977, 37:4650-4654 922745
22. Rose DP Pruitt BT Plasma prolactin levels in patients with breast cancer Cancer 1981, 48:2687-2691 10.1002/ 1097-0142(19811215)48:12<2687::AID-CNCR2820481221>3.0.CO;2-A 7306924
23. Meyer F Brisson J Morrison AS Brown JB Endogenous sex hormones, prolactin, and mammographic features of breast tissue in premenopausal women J Natl Cancer Inst 1986, 77:617-620 3462405
24. Love RR Rose DR Surawicz TS Newcomb PA Prolactin and growth hormone levels in premenopausal women with breast cancer and healthy women with a strong family history of breast cancer Cancer 1991, 68:1401-1405 10.1002/ 1097-0142(19910915)68:6<1401::AID-CNCR2820680637>3.0.CO;2-K 1873792
25. Ingram DM Nottage EM Roberts AN Prolactin and breast cancer risk Med J Aust 1990, 153:469-473 2215338
26. Secreto G Recchione C Cavalleri A Miraglia M Dati V Circulating levels of testosterone, 17 beta-oestradiol, luteinising hormone and prolactin in postmenopausal breast cancer patients Br J Cancer 1983, 47:269-275 6824571
27. Bernstein L Ross RK Endogenous hormones and breast cancer risk Epidemiol Rev 1993, 15:48-65 8405212
28. Helzlsouer KJ Alberg AJ Bush TL Longcope C Gordon GB Comstock GW A prospective study of endogenous hormones and breast cancer Cancer Detect Prev 1994, 18:79-85 8025899
29. Tworoger SS Eliassen AH Sluss P Hankinson SE A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer J Clin Oncol 2007, 25:1482-1488 10.1200/ JCO.2006.07.6356 17372279
30. Truong AT Duez C Belayew A Renard A Pictet R Bell GI Martial JA Isolation and characterization of the human prolactin gene Embo J 1984, 3:429-437 557362 6325171
31. Berwaer M Martial JA Davis JR Characterization of an up-stream promoter directing extrapituitary expression of the human prolactin gene Mol Endocrinol 1994, 8:635-642 10.1210/me.8.5.635 8058071
32. DiMattia GE Gellersen B Duckworth ML Friesen HG Human prolactin gene expression. The use of an alternative noncoding exon in decidua and the IM-9-P3 lymphoblast cell line J Biol Chem 1990, 265:16412-16421 1697858
33. Arden KC Boutin JM Djiane J Kelly PA Cavenee WK The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5 Cytogenet Cell Genet 1990, 53:161-165 2369845
34. Hu ZZ Zhuang L Meng J Tsai-Morris CH Dufau ML Complex 5' genomic structure of the human prolactin receptor: Multiple alternative exons 1 and promoter utilization Endocrinology 2002, 143:2139-2142 10.1210/ en.143.6.2139 12021177
35. Hu ZZ Zhuang L Meng J Leondires M Dufau ML The human prolactin receptor gene structure and alternative promoter utilization: The generic promoter hPIII and a novel human promoter hP(N) J Clin Endocrinol Metab 1999, 84:1153-1156 10.1210/jc.84.3.1153 10084611
36. Hu ZZ Meng J Dufau ML Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11 J Biol Chem 2001, 276:41086-41094 10.1074/ jbc.M102109200 11518703
37. Trott JF Hovey RC Koduri S Vonderhaar BK Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein J Mol Endocrinol 2003, 30:31-47 10.1677/jme.0.0300031 12580759
38. Dunning AM Dowsett M Healey CS Tee L Luben RN Folkerd E Novik KL Kelemen L Ogata S Pharoah PD Easton DF Day NE Ponder BA Polymorphisms associated with circulating sex hormone levels in postmenopausal women J Natl Cancer Inst 2004, 96:936-945 15199113
39. Miller DT Zee RY Suk Danik J Kozlowski P Chasman DI Lazarus R Cook NR Ridker PM Kwiatkowski DJ Association of common CRP gene variants with CRP levels and cardiovascular events Ann Hum Genet 2005, 69:623-638 10.1111/j.1529-8817.2005.00210.x 16266402
40. de Bakker PI Yelensky R Pe'er I Gabriel SB Daly MJ Altshuler D Efficiency and power in genetic association studies Nat Genet 2005, 37:1217-1223 10.1038/ng1669 16244653
41. Canbay E Degerli N Gulluoglu BM Kaya H Sen M Bardakci F Could prolactin receptor gene polymorphism play a role in pathogenesis of breast carcinoma? Curr Med Res Opin 2004, 20:533-540 10.1185/030079904125003232 15119991
42. Haiman CA Stram DO Pike MC Kolonel LC Burtt NP Altshuler D Hirschhorn J Henderson BE A comprehensive haplotype analysis of CYP19 and breast cancer risk: The Multiethnic Cohort Hum Mol Genet 2003, 12:2679-2692 10.1093/hmg/ddg294 12944421
43. Gabriel SB Schaffner SF Nguyen H Moore JM Roy J Blumenstiel B Higgins J DeFelice M Lochner A Faggart M Liu-Cordero SN Rotimi C Adeyemo A Cooper R Ward R Lander ES Daly MJ Altshuler D The structure of haplotype blocks in the human genome Science 2002, 296:2225-2229 10.1126/science.1069424 12029063
44. Stram DO Haiman CA Hirschhorn JN Altshuler D Kolonel LN Henderson BE Pike MC Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study Hum Hered 2003, 55(1):227-236 10.1159/ 000071807
45. Stevens A Ray D Alansari A Hajeer A Thomson W Donn R Ollier WE Worthington J Davis JR Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus Arthritis & Rheumatism 2001, 44:2358-2366 10.1002/ 1529-0131(200110)44:10<2358::AID-ART399>3.0.CO;2-K
46. Stevens A Ray DW Worthington J Davis JR Polymorphisms of the human prolactin gene - implications for production of lymphocyte prolactin and systemic lupus erythematosus Lupus 2001, 10:676-683 10.1191/ 096120301717164903 11721693
47. Vaclavicek A Hemminki K Bartram CR Wagner K Wappenschmidt B Meindl A Schmutzler RK Klaes R Untch M Burwinkel B Forsti A Association of prolactin and its receptor gene regions with familial breast cancer Journal of Clinical Endocrinology & Metabolism 2006, 91:1513-1519 10.1210/jc.2005-1899
48. International HapMap Project http://www.hapmap.org
49. Kolonel LC Henderson BE Hankin JH Nomura AMY Wilkens LR Pike MC Stram DO Monroe KR Earle ME Nagamine FS A multiethnic cohort in Hawaii and Los Angeles: Baseline Characteristics American Journal of Epidemiology 2000, 151:346 -57 10695593
50. National Center of Biotechnology Information http://www.ncbi.nlm.nih.gov/ projects/SNP
51. Celera http://www.celera.com
52. Excoffier L Slatkin M Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population Mol Biol Evol 1995, 12:921-927 7476138
53. TagSNPs Program http://www-rcf.usc.edu/~stram
54. Stram DO Tag SNP selection for association studies Genet Epidemiol 2004, 27:365-374 10.1002/gepi.20028 15372618
55. Hankinson SE London SJ Chute CG Barbieri RL Jones L Kaplan LA Sacks FM Stampfer MJ Effect of transport conditions on the stability of biochemical markers in blood Clin Chem 1989, 35:2313-2316 2591049
56. Freedman ML Penney KL Stram DO Le Marchand L Hirschhorn JN Kolonel LN Altshuler D Henderson BE Haiman CA Common variation in BRCA2 and breast cancer risk: A haplotype-based analysis in the Multiethnic Cohort Human Molecular Genetics 2004, 13:2431-2441 10.1093/hmg/ddh270 15317758
57. International HapMap C A haplotype map of the human genome. [see comment] Nature 2005, 437:1299-1320 1880871 16255080 10.1038/nature04226
58. Rosenberg NA Pritchard JK Weber JL Cann HM Kidd KK Zhivotovsky LA Feldman MW Genetic structure of human populations. [see comment] Science 2002, 298:2381-2385 10.1126/science.1078311 12493913
59. Ioannidis JP Ntzani EE Trikalinos TA 'Racial' differences in genetic effects for complex diseases. [see comment] Nature Genetics 2004, 36:1312-1318 10.1038/ng1474 15543147
60. Zaykin DV Westfall PH Young SS Karnoub MA Wagner MJ Ehm MG Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals Hum Hered 2002, 53:79-91 10.1159/000057986 12037407
61. LocusView http://www.broad.mit.edu/mpg/locusview/