Investigation of the dopamine D5 receptor gene (DRD5) in adult attention deficit hyperactivity disorder

Neuroscience Letters

Volumn 432, Issue 1, 2008, Pages 50-53

  Squassina, Alessio ^a   Lanktree, Matthew ^a   De Luca, Vincenzo ^a   Jain, Umesh ^a   Krinsky, Marilee ^a   Kennedy, James L ^a   Muglia, Pierandrea ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

ADHD; Association; DRD5; FBAT; STR

Indexed keywords

DINUCLEOTIDE; DOPAMINE 5 RECEPTOR;

ADULT; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; CODON; CONTROLLED STUDY; FAMILY HEALTH; GENE FREQUENCY; GENE REPLICATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE REPEAT; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RATING SCALE; SCORING SYSTEM;

ADULT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CASE-CONTROL STUDIES; FAMILY HEALTH; FEMALE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, DOPAMINE D5;

EID: 38749143965     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.12.003     Document Type: Article

References (28)

1. Bakker S.C., van der Meulen E.M., Oteman N., Schelleman H., Pearson P.L., Buitelaar J.K., and Sinke R.J. DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families. Am. J. Med. Genet. (Neuropsych. Genet.) 132 (2005) 50-52
2. Barr C.L., Wigg K.G., Feng Y., Zai G., Malone M., Roberts W., Schachar R., Tannock R., and Kennedy J.L. Attention-deficit hyperactivity disorder and the gene for the dopamine D5 receptor. Mol. Psychiatry 5 (2000) 548-551
3. Brown T.E. Brown ADD Scale (1996), The Psychological Corporation, San Antonio, Texas, Harcourt Brace & Company
4. Comings D.E., Comings B.G., Muhleman D., Dietz G., Shahbahrami B., Tast D., Knell E., Kocsis P., Baumgarten R., Kovacs B.W., Levy D.L., Smith M., Borison R.L., Evans D., Klein L.M., MacMurray J., Tosk J.M., Sverd G., Gysin R., and Flanagan S.D. The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders. JAMA 266 (1991) 1793-1800
5. Daly G., Hawi Z., Fitzgerald M., and Gill M. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol. Psychiatry 4 (1999) 192-196
6. Dougherty D., Bonab A., Spencer T., Rauch S., Madras B., and Fischman A. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354 (1999) 2132-2133
7. Dupont W.D., and Plummer W.D. PS power and sample size program available for free on the Internet. Controlled Clin. Trials 18 (1997) 274
8. Faraone S.V., Biederman J., Feighner J.A., and Monuteaux M.C. Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid?. J. Consult Clin. Psychol. 68 (2000) 830-842
9. Faraone S.V., Spencer T., Aleardi M., Pagano C., and Biederman J. Meta-analysis of the efficacy of methylphenidate for treating adult attention-deficit/hyperactivity disorder. J. Clin. Psychopharmacol. 24 (2004) 24-29
10. Hawi Z., Lowe N., Kirley A., Gruenhage F., Nöthen M., Greenwood T., Kelsoe J., Fitzgerald M., and Gill M. Linkage disequilibrium mapping at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci. Mol. Psychiatry 8 (2003) 299-308
11. Hawi Z., Segurado R., Conroy J., Sheehan K., Lowe N., Kirley A., Shields D., Fitzgerald M., Gallagher L., and Gill M. Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. Am. J. Hum. Genet. 77 (2005) 958-965
12. Horvath S., Xu X., and Laird N.M. The family based association test method: strategies for studying general genotype-phenotype associations. Eur. J. Hum. Genet. 9 (2001) 301-306
13. Levy F., Hay D.A., McStephen M., Wood C., and Waldman I. Attention-deficit hyperactivity disorder: a category or a continuum? Genetic analysis of a large scale twin study. J. Am. Acad. Child Adolesc. Psychiatry 36 (1997) 737-744
14. Li D., Sham P.C., Owen M.J., and He L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum. Mol. Genet. 15 (2006) 2276-2284
15. Lowe N., Kirley A., Hawi Z., Sham P., Wickham H., Kratochvil C.J., Smith S.D., Lee S.Y., Levy F., Kent L., Middle F., Rohde L.A., Roman T., Tahir E., Yazgan Y., Asherson P., Mill J., Thapar A., Payton A., Todd R.D., Stephens T., Ebstein R.P., Manor L., Barr C.L., Wigg K.G., Sinke R.J., Buitelaar J.K., Smalley S.L., Nelson S.F., Biederman J., Faraone S.V., and Gill M. Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes. Am. J. Hum. Genet. 74 (2004) 348-356
16. Maher B.S., Marazita M.L., Ferrell R.E., and Vanyukov M.M. Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis. Psychiatry Genet. 12 (2002) 207-215
17. Manor I., Corbex M., Eisenberg J., Gritsenkso I., Bachner-Melman R., Tyano S., and Ebstein R.P. Association of the Dopamine D5 Receptor With Attention Deficit Hyperactivity Disorder (ADHD) and Scores on a Continuous Performance Test (TOVA). Am. J. Med. Genet. (Neuropsych. Genet.) 127 (2004) 73-77
18. Misener V.L., Luca P., Azeke O., Crosbie J., Waldman I., Tannock R., Roberts W., Malone M., Schachar R., Ickowicz A., Kennedy J.L., and Barr C.L. Linkage of the dopamine receptor D1 gene to attention-deficit/hyperactivity disorder. Mol. Psychiatry 9 (2004) 500-509
19. Muglia P., Jain U., Macciardi F., and Kennedy J.L. Adult attention deficit hyperactivity disorder and the dopamine D4 receptor gene. Am. J. Med. Genet. (Neuropsych. Genet.) 96 (2000) 273-277
20. Muglia P., Jain U., Inkster B., and Kennedy J.L. A Quantitative Trait Locus Analysis of the Dopamine Transporter Gene in Adults with ADHD. Neuropsychopharmacology 27 (2002) 655-662
21. Payton A., Holmes J., Barrett J.H., Hever T., Fitzpatrick H., Trumper A.L., Harrington R., McGuffin P., O'Donovan M., Owen M., Ollier W., Worthington J., and Thapar A. Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. Am. J. Med. Genet. (Neuropsych. Genet.) 105 (2001) 464-470
22. Sherrington R., Mankoo B., Attwood J., Kalsi G., Curtis D., Buetow K., Povey S., and Gurling H. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1. Genomics 18 (1993) 423-425
23. Tahir E., Yazgan Y., Cirakoglu B., Ozbay F., Waldman I., and Asherson P.J. Association and linkage of DRD4 and DRD5 with attention deficit hyperactivity disorder (ADHD) in a sample of Turkish children. Mol. Psychiatry 5 (2000) 396-404
24. Thapar A., Holmes J., Poulton K., and Harrington R. Genetic basis of attention deficit and hyperactivity. Br. J. Psychiatry 174 (1999) 105-111
25. Volkow N.D., Wang G.J., Fowler J.S., Logan G., Angrist B., Hitzemann R., Lieberman J., and Pappas N. Effects of methylphenidate on regional brain glucose metabolism in humans: relationship to dopamine D2 receptors. Am. J. Psychiatry 154 (1997) 50-55
26. Volkow N.D., Chang L., Wang G.J., Fowler J.S., Ding Y.S., Sedler M., Logan J., Franceschi D., Gatley J., Hitzemann R., Gifford A., Wong C., and Pappas N. Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex. Am. J. Psychiatry 158 (2001) 2015-2021
27. Waldman I.D., Rowe C., Abramowitz A., Kozel T., Mohr H., Sherman S.L., Cleveland H.H., Sanders M.L., Gard J.M., and Stever C. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am. J. Hum. Genet. 63 (1998) 1767-1776
28. Ward M.F., Wender P.H., and Reimherr F.W. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am. J. Psychiatry 150 (1993) 885-890