Remaking the body? Scientists' genetic discourses and practices as examples of changing expectations on embryonic stem cell therapy for diabetes

New Genetics and Society

Volumn 26, Issue 3, 2007, Pages 251-268

  Wainwright, Steven ^a   Williams, Clare ^a   Michael, Mike ^b   Farsides, Bobbie ^c   Cribb, Alan ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL TRANSFORMATION; EMBRYONIC STEM CELL; GENETIC MANIPULATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MEDICAL PRACTICE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION;

EID: 38749139903     PISSN: 14636778     EISSN: 14699915     Source Type: Journal    
DOI: 10.1080/14636770701701782     Document Type: Article

References (60)

1. Alberts, B. et al. (2002) Molecular Biology of the Cell, 4th edn (New York: Garland Science).
2. Birke, L. (1999) Feminism and the Biological Body (Edinburgh: Edinburgh University Press).
3. Bloor, D. (1976) Knowledge and Social Imagery (London: RKP).
4. Blyszczuk, P. et al. (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells, Proceedings of the National Academy of Sciences USA, 100(3), pp. 998-1003.
5. Bonner-Weir, S. & Weir, G.C. (2005) New sources of pancreatic beta-cells, Nature Biotechnology, 23, pp. 857-86.
6. Brown, N. & Michael, M. (2003) An analysis of changing expectations: or retrospecting prospects and prospecting retrospects, Technology Analysis and Strategic Management, 15(1), pp. 3-18.
7. Brown, N. & Webster, A. (2004) New Medical Technologies and Society: Reordering Life (Cambridge: Polity Press).
8. Burns, C.J. et al. (2004) Human embryonic stem cells differentiate to express pancreatic and beta cell specific genes, Diabetic Medicine, 21(S2), p. 36.
9. Collins, H. (1985) Changing Order (London: Sage).
10. Cooper, M. (2004) Regenerative medicine: stems cells and the science of monstrosity, Journal of Medical Ethics: Medical Humanities, 30, pp. 12-22.
11. Cooper, M. (2006) Resuscitations: stem cells and the crisis of old age, Body & Society, 12, pp. 1-23.
12. Franklin, S. (2001) Culturing biology: cell lines for the second millennium, Health, 5, pp. 335-54.
13. Franklin, S. (2005) Stem Cells R Us: emergent life forms and the global biological. In Ong, A. & Collier, S.J. (eds) Global Assemblages: Technology, Politics and Ethics as Anthropological Problems, pp. 59-78 (New York: Blackwell).
14. Fujimura, J.H. (1997) Crafting Science: Sociohistory of the Quest for the Genetics of Cancer (Cambridge, MA: Harvard University Press).
15. Gearhart, J. (2005) Stem Cells: Nuclear Reprogramming and Therapeutic Applications (Novartis Foundation Symposium New York: Wiley).
16. Gieryn, T.F. (1983) Boundary-work and the demarcation of science from non-science: strains and interests in professional ideologies of scientists, American Sociological Review, 48, pp. 781-95.
17. Gieryn, T.F. (1999) Cultural Boundaries of Science: Credibility on the Line (Chicago: Chicago University Press).
18. Glasner, P. (1998) Patrolling the boundaries or tracing the contours: cartographic metaphors and the human genome project. In Wheale, P. et al. (eds) The Social Management of Genetic Engineering, pp. 29-44 (Aldershot: Ashgate).
19. Hauskeller, C. et al. (2005) Crossing Borders: Cultural, Religious, and Political Differences Concerning Stem Cell Research. A Global Approach (Münster: Agenda Verlag).
20. Hedgecoe, A. (2002) Reinventing diabetes: classification, division and the geneticization of disease, New Genetics & Society, 21, pp. 7-27.
21. Institute of Medicine (2002) Stem Cells and the Future of Regenerative Medicine (Washington: National Academy Press).
22. Irwin, A. & Michael, M. (2003) Science, Social Theory and Public Knowledge (Maidenhead, Berks: Open University Press/McGraw-Hill).
23. Jasanoff, S. (2005) Designs on Nature: Science and Democracy in Europe and the United States (Princeton: Princeton University Press).
24. Jones, M. & Salter, B. (2003) The governance of human genetics: policy discourse and constructions of public trust, New Genetics & Society, 22, pp. 21-42.
25. Jones, P.M. et al. (2004) Beta-cell replacement technologies: the potential of stem cells for transplantation therapy of Type 1 diabetes, Drug Discovery Today: Therapeutic Strategies, 17(2), pp. 213-17.
26. Keating, P. & Cambrosio, A. (2003) Biomedical Platforms: Realigning the Normal and the Pathological in Late-Twentieth Century Medicine (Cambridge: MIT Press).
27. Kitzinger, J. & Williams, C. (2005) Envisaging the future: legitimizing hope and calming fears in the stem cell debate, Social Science & Medicine, 61, pp. 731-40.
28. Lanza, R. et al. (2004) Handbook of Stem Cells. Volume 1: Embryonic Stem Cells (Amsterdam: Elsevier).
29. Latour, B. (1987) Science in Action: How to Follow Scientists and Engineers through Society (Cambridge, MA: Harvard University Press).
30. Lowy, I. (1997) Between Bench and Bedside: Science, Healing and Interleukin-2 in Cancer (Cambridge, MA: Harvard University Press).
31. Lundin, S. (1999) The boundless body: cultural perspectives on xenotransplantation, Ethnos, 64, pp. 5-31.
32. Michael, M. (In press) Technoscience and Everyday Life (Maidenhead, Berks: Open University Press/McGraw-Hill).
33. Michael, M. & Brown, N. (2004) The meat of the matter: grasping and judging xenotransplantation, Public Understanding of Science, 13, pp. 379-97.
34. Michael, M. & Brown, N. (2005) Scientific citizenships: self-representations of xenotransplantation's publics, Science as Culture, 14(1), pp. 38-57.
35. Mooney, C. (2005) The Republican War on Science (New York: Basic Books).
36. Narushima, M. et al. (2005) A human β-cell line for transplantation therapy to control Type 1 diabetes, Nature Biotechnology, 23, pp. 1274-82.
37. Nowotny, H. et al. (2001) Re-Thinking Science: Knowledge and the Public in an Age of Uncertainty (Cambridge: Polity Press).
38. Parry, S. (2003) The politics of cloning: mapping the rhetorical convergence of embryos and stem cells in parliamentary debates, New Genetics and Society, 22, pp. 177-200.
39. Petersen, A. & Bunton, R. (2002) The New Genetics and the Public's Health (London: Routledge).
40. Rabinow, P. (1996) Making PCR: A Story of Biotechnology (Chicago: Chicago University Press).
41. Rajagopal, J. et al. (2003) Insulin staining of ES cell progeny from insulin uptake, Science, 299(5605), p. 363.
42. Rajan, K.S. (2006) Biocapital: the Constitution of Postgenomic Life (Durham, NC: Duke University Press).
43. Resnik, D.B. (2002) The commercialization of human stem cells: ethical and policy issues, Health Care Analysis, 10, pp. 127-54.
44. Ruse, M. & Pynes, C.A. (2003) The Stem Cell Controversy: Debating the Issues (New York: Prometheus).
45. Salter, Board Jones, M. (2002) Human genetic technologies: European governance and the politics of bioethics, Nature Reviews Genetics, 3(40), pp. 808-14.
46. Scott, C.T. (2006) Stem Cell Now: From the Experiment that Shook the World to the New Politics of Life (New York: Pi Press).
47. Shapiro, A.M.J. et al. (2000) Islet transplantation in seven patients with Type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regime, New England Journal of Medicine, 343, pp. 230-8.
48. Snow, N.E. (2003) Stem Cell Research: New Frontiers in Science and Ethics (Notre Dame: University of Notre Dame Press).
49. Strauss, A.L. (1987) Qualitative Analysis for Social Scientists (Cambridge: Cambridge University Press).
50. Vogel, G. (2001) Developmental biology: stem cells are coaxed to produce insulin, Science, 292, pp. 615-17.
51. Michael, M. et al.(2007) From core set to assemblage: on the dynamics of exclusion and inclusion in the failure to derive beta cells from embryonic stem cells, Science Studies (forthcoming).
52. Wainwright, S.P. et al. (2006a) Ethical boundary-work in the embryonic stem cell laboratory, Sociology of Health & Illness, 28, pp. 732-48.
53. Wainwright, S.P. et al. (2006b) From bench to bedside? Biomedical scientists' expectations of stem cell science as a future therapy for diabetes, Social Science & Medicine, 63, pp. 2052-64.
54. Wainwright, S.P. et al. (2006c) Real science, biological bodies and stem cells: constructing images of beta cells in the biomedical science lab, Social Theory & Health, 4, pp. 275-98.
55. Waldby, C. (2002) Stem cells, tissue cultures and the production of biovalue, Health, 6, pp. 305-23.
56. Weber, R. (1990) Basic Content Analysis (London: Sage).
57. Webster, A. (2002) Innovative health technologies and the social: redefining health, medicine and the body, Current Sociology, 50, pp. 443-57.
58. Williams, C. et al. (2003) Envisaging the embryo in stem cell research: discursive strategies and media reporting of the ethical debates, Sociology of Health & Illness, 25, pp. 793-814.
59. Williams, S.J. et al. (2003) Debating Biology: Sociological Reflections on Health, Medicine and Society (London: Routledge).
60. Zimmet, P. et al. (2001) Global and societal implications of the diabetes epidemic, Nature, 414, pp. 782-7.