Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 1162-1166

  Costa, Jorge C S ^a   Neves, Josiane S ^a   de Souza, Marcus V N ^a   Siqueira, Rodrigo A ^a   Romeiro, Nelilma C ^b   Boechat, Nubia ^a   Silva, Patrícia M R e ^a   Martins, Marco A ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Allergy; Anesthetic activity; Antispasmodic activity; Lidocaine

Indexed keywords

2 (DIETHYLAMINO) N (DIMETHYL PHENYL) ACETAMIDE; 2 (DIETHYLAMINO) N (TRIFLUOROMETHYLPHENYL) ACETAMIDE; HISTAMINE; LIDOCAINE; LOCAL ANESTHETIC AGENT; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

ALLERGIC DISEASE; ANAPHYLAXIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ILEUM CONTRACTION; LOCAL ANESTHESIA; NONHUMAN; RAT; SPASMOLYSIS; STRUCTURE ACTIVITY RELATION;

ANESTHETICS, LOCAL; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE; LIDOCAINE; MOLECULAR STRUCTURE; PARASYMPATHOLYTICS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 38749131966     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.122     Document Type: Article

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