Toxicological evaluation of transgenic rice flour with an Escherichia coli phytase gene appA by sub-chronic feeding study in Wistar rats

Journal of the Science of Food and Agriculture

Volumn 88, Issue 3, 2008, Pages 382-388

  Tsai, Cheng Chih ^a   Lai, Chieh Hsien ^a   Yang, Chi Sheng ^a   Lin, Chien Ku ^a   Tsen, Hau Yang ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Food safety; Phytase; Sub chronic feeding study; Transgenic rice

Indexed keywords

ANIMALIA; ESCHERICHIA COLI; RATTUS; RATTUS NORVEGICUS; SUIDAE;

EID: 38749122864     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.3096     Document Type: Article

References (31)

1. Ravindran V, Bryden WL and Kornegay ET, Phytates: occurrence, bioavailability and implications in poultry nutrition. Poult Avian Biol Rev 6:125-143 (1995).
2. Brinch-Pedersen H, Sorensen LD and Holm PB, Engineering crop plants: getting a handle on phosphate. Trends Plant Sci 7:118-125 (2002).
3. Pen J, Verwoerd TC, van Paridin PA, Beukeder RF, van der Elzen PJM and Geerse K, Phytase-containing transgenic seed as a novel feed additive for improved phosphorus utilization. Biotechnology 11:811-814 (1993).
4. Verwoerd TC, van Paridon PA, van Ooyen AJ, van Lent JW, Hoekema A and Pen J, Stable accumulation of Aspergillus niger phytase in transgenic tobacco leaves. Plant Physiol 109:1199-1205 (1995).
5. Li J, Hegeman CE, Hanlon RW, Lacy GH, Denbow MD and Grabau EA, Secretion of active recombinant phytase from soybean cell-suspension cultures. Plant Physiol 114:1103-1111 (1997).
6. Denbow DM, Grabau EA, Lacy GH, Kornegay ET, Russell DR and Umbeck PF, Soybeans transformed with a fungal phytase gene improve phosphorus availability for broilers. Poult Sci 77:878-881 (1998).
7. Ullah AH, Sethumadhavan K, Mullaney EJ, Ziegelhoffer T and Austin-Phillips S, Cloned and expressed fungal phyA gene in alfalfa produces a stable phytase. Biochem Biophys Res Commun 290:1343-1348 (2002).
8. Brinch-Pedersen H, Olesen A, Rasmussen SK and Holm PB, Generation of transgenic wheat (Tritivum aestivum L.) for constitutive accumulation of an Aspergillus phytase. Mol Breed 6:195-206 (2000).
9. Zhang ZB, Kornegay ET, Radcliffe JS, Wilson JH and Veit HP, Comparison of phytase from genetically engineered Aspergillus and canola in weanling pig diets. J Anim Sci 78:2868-2878 (2000).
10. Lucca P, Hurrell R and Potrykus I, Genetic engineering approaches to improve the bioavailability and the level of iron in rice grains. Theor Appl Genet 102:392-397 (2001).
11. Ponstein AS, Bade JB, Verwoerd TC, Molendijk L, Storms J and Beudeker RF, Stable expression of phytase (phyA) in canola (Brassica napus) seeds: towards a commercial product. Mol Breed 10:31-44 (2002).
12. Hong CY, Chen KJ, Liu LF, Tseng TH, Wang CS and Yu SM, Production of two highly active bacterial phytases with broad pH optima in germinating transgenic rice seeds. Transgenic Res 13:29-39 (2004).
13. Brandt P, Overview of the current status of genetically modified plants in Europe as compared to the USA. J Plant Physiol 160:735-742 (2003).
14. OECD, Safety Evaluation of Foods Derived by Modern Biotech nology: Concepts and Principles. [Online]. Organization for Economic Cooperation and Development, Paris. Available: http://www.oecd.org/dataoecd/59/3/1946129.pdf access date: [20 September 2007] (1993).
15. OECD, ENV/JM/MONO 2004 15, Consensus document on compositional considerations for new varieties of rice (Oryza sativa): key food and nutrients and feed nutrients and anti-nutrients (2004).
16. FAO/WHO, Strategies for Assessing the Safety of Foods Produced by Biotechnology. Report of a joint FAO/WHO consultation. World Health Organization, Geneva (1991).
17. FAO/WHO, Safety Aspects of Genetically Modified Foods of Plant Origin. [Online]. Report of a joint FAO/WHO expert consultation on foods derived from biotechnology, Geneva, Switzerland, 29 May-2 June 2000. Food and Agriculture Organization of the United Nations, Rome. Available: ftp://ftp.fao.org/es/esn/food/gmreport.pdf [22 August 2007].
18. FAO/WHO, Evaluation of Allergenicity of Genetically Modified Foods. Report of a joint FAO/WHO expert consultation on allergenicity of foods derived from biotechnology, Rome, January (2001).
19. Barlow SM, Greig JB, Bridges JW, Carere A, Carpy AJ, Galli CL, et al, Hazard identification by methods of animal-based toxicology. Food Chem Toxicol 40:145-191 (2002).
20. Momma K, Hashimoto W, Yoon HJ, Ozawa S, Fukuda Y, Kawai S, et al, Safety assessment of rice genetically modified with soybean glycinin by feeding studies on rats. Biosci Biotechnol Biochem 64:1881-1886 (2000).
21. Poulsen M, Kroghsbo S, Schrøder M, Wilcks A, Jacobsen H, Miller A, et al, A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem Toxicol 45:350-363 (2007).
22. Shimizu M, Purification and characterization of phytase from Bacillus subtilis (natto) N-77. Biosci Biotechnol Biochem 56:1266-1269 (1992).
23. Zhuo Q, Chen X, Piao J and Gu L, Study on food safety of genetically modified rice which expressed cowpea trypsin inhibitor by 90 day feeding test on rats. Wei Sheng Yan Jiu 33:176-179 (2004).
24. Wang ZH, Wang Y, Cui HR, Xia YW and Altorsaar I, Toxicological evaluation of transgenic rice flour with a synthetic cry1Ab gene from Bacillus thuringiensis. J Sci Food Agric 82:738-744 (2002).
25. Schrøder M, Poulsen M, Wilcks A, Kroghsbo S, Miller A, Frenzel T, et al, A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem Toxicol 45:339-349 (2007).
26. Liang CT, Chang MH, Hong CC and Huang KJ, Establishing the blood chemistry reference values for SPF rats and mice. J Chin Soc Vet Sci 25:55-68 (1999).
27. Gentile JM, Roneker KR, Crowe SE, Pond WG and Lei XG, Effectiveness of an experimental consensus phytase in improving dietary phytate-phosphorus utilization by weanling pigs. J Anim Sci 81:2751-2757 (2003).
28. Augspurger NI, Webel DM, Lei XG and Baker DH, Efficacy of an E. coli phytase expressed in yeast for releasing phytate-bound phosphorus in young chicks and pigs. J Anim Sci 81:474-483 (2003).
29. Swendseid ME, Biochemical assessment of protein and amino acid status, in Proceedings of a National Conference Sponsored by the Food and Nutrition Council of the American Health Foundation: Nutritional Status Assessment of the Individual, ed. by Livingston GE. Food and Nutrition Press, New York, pp. 205-211 (1987).
30. Hashimoto W, Momma K, Yoon HJ, Ozawa S, Ohkawa Y, Ishige T, et al, Safety assessment of transgenic potatoes with soybean glycinin by feeding studies in rats. Biosci Biotechnol Bioehem 63:1942-1946 (1999).
31. Ciofalo V, Barton N, Kretz K, Baird J, Cook M and Shanahan D, Safety evaluation of a phytase, expressed in Schizosaccharomyces pombe, intended for use in animal feed. Regul Toxicol Pharmacol 37:286-292 (2003).