Progesterone attenuates neuroleptic-induced orofacial dyskinesia via the activity of its metabolite, allopregnanolone, a positive GABAA modulating neurosteroid

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 2, 2008, Pages 451-461

  Bishnoi, Mahendra ^a   Chopra, Kanwaljit ^b   Kulkarni, Shrinivas K ^a,b  

^a PANJAB UNIVERSITY   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

GABAergic hypofunction; Progesterone; Tardive dyskinesia

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; DOPAMINE; FINASTERIDE; HALOPERIDOL; NEUROLEPTIC AGENT; NEUROSTEROID; PROGESTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DRUG ANTAGONISM; DRUG EFFECT; GABAERGIC SYSTEM; MALE; NEUROPROTECTION; NONHUMAN; OROFACIAL DYSKINESIA; RAT; TARDIVE DYSKINESIA;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN DISEASES; CONTROL GROUPS; DISEASE MODELS, ANIMAL; DOPAMINE; DYSKINESIA, DRUG-INDUCED; GAMMA-AMINOBUTYRIC ACID; HALOPERIDOL; MALE; MOVEMENT DISORDERS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PREGNANOLONE; PROGESTERONE; RATS; RATS, INBRED ACI; RECEPTORS, GABA-A;

EID: 38749107027     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2007.09.017     Document Type: Article

References (59)

1. Abílio V.C., Vera J.A.R., Ferreira L.S.M., Duarte C.R.M., Carvalho R.C., and Grassl C. Effects of melatonin on orofacial movements in rats. Psychopharmacology 161 (2002) 340-347
2. Abílio V.C., Araujo C.C.S., Bergamo M., Calvente P.R.V., and D'Almeida V. Vitamin E attenuates reserpine-induced oral dyskinesia and striatal gssg/gsh ratio enhancement in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 27 (2003) 109-114
3. Alves S.E., McEwen B.S., Hayashi S., Korach K.S., Pfaff D.W., and Ogawa S. Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice. J Comp Neurol 427 (2000) 185-195
4. Araujo N.P., Abílio V.C., Silva R.H., Pereira R.C., Carvalho R.C., Gonzalez C., et al. Effects of topiramate on oral dyskinesia induced by reserpine. Brain Res Bull 64 4 (2004) 331-337
5. Azzolina B., Ellsworth K., Andersson S., Geissler W., Bull H.G., and Harris G.S. Inhibition of rat 5α-reductases by finasteride: evidence for isozyme differences in mechanism of inhibition. J Steroid Biochem Mol Biol 61 (1997) 55-64
6. Babior B.M., Kipner R.S., and Cerutte J.T. Biological defense mechanism. The production by leukocytes of superoxide, a potential bacterial agent. J Clin Invest 52 (1973) 7451-7744
7. Barbaccia M.L., Affricano D., Purdy R.H., Maciocco E., Spiga F., and Biggio G. Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat. Neuropsychopharmacology 25 4 (2001) 489-497
8. Bergamo M., Abílio V.C., Queiroz C.M., Barbosa-Júnior H.N., Abdanur L.R., and Frussa-Filho R. Effects of age on a new animal model of tardive dyskinesia. Neurobiol Aging 18 6 (1997) 623-629
9. Bishnoi M., Chopra K., and Kulkarni S.K. Involvement of adenosinergic receptor system in an animal model of tardive dyskinesia and associated behavioural, biochemical and neurochemical changes. Eur J Pharmacol 552 1-3 (2006) 55-66
10. Bishnoi M., Kumar A., Chopra K., and Kulkarni S.K. Comparative neurochemical changes associated with chronic administration of typical and atypical neuroleptics: implications in tardive dyskinesia. Indian J Exp Biol 45 2 (2007) 175-179
11. Burger M.E., Alves A., Callegari L., Athayde F.R., Nogueira C.W., Zeni G., et al. Ebselen attenuates reserpine-induced orofacial dyskinesia and oxidative stress in rat striatum. Prog Neuro-Psychopharmacol Biol Psychiatry 27 (2003) 135-140
12. Burger M., Fachinetto R., Callegari L., Paixao M.W., Braga A.L., and Rocha J.B. Effects of age on reserpine-induced orofacial dyskinesia and possible protection of diphenyl diselenide. Brain Res Bull 64 4 (2004) 339-345
13. Burger M.E., Fachinetto R., Zeni G., and Rocha J.B. Ebselen attenuates haloperidol-induced orofacial dyskinesia and oxidative stress in rat brain. Pharmacol Biochem Behav 81 3 (2005) 608-615
14. Burger M.B.E., Fachineto R., Alves A., Callegari L., and Rocha J.B.T. Acute reserpine and sub-chronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats. Brain Res 1031 2 (2005) 202-210
15. Cadet J.L., Lohr J.B., and Jeste D.V. Free radicals and tardive dyskinesia. Trends Neurosci 9 (1986) 107-108
16. Calvente P., Araujo C., Bergamo M., Abílio V., D'Almeida V., Ribeiro Rde A., and Frussa F.R. The mitochondrial toxin 3-nitropropionic acid aggravates reserpine-induced oral dyskinesia in rats. Prog Neuro-Psychopharmacol Biol Psychiatry 26 (2002) 1-5
17. Castro J.P., Frussa-Filho R., Fukushiro D.F., Silva R.H., Medrano W.A., Ribeiro Rde A., et al. Effects of baclofen on reserpine-induced vacuous chewing movements in mice. Brain Res Bull 68 6 (2006) 436-441
18. Celotti F., Negri-Cesi P., and Poletti A. Steroid metabolism in the mammalian brain: 5α-reduction and aromatization. Brain Res Bull 44 (1997) 365-375
19. Charalampopoulos I., Dermitzaki E., Vardouli L., Tsatsanis C., Stournaras C., Margioris A.N., et al. Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization. Endocrinology 146 8 (2005) 3309-3318
20. Church W.H. Column chromatography analysis of brain tissue: an advanced laboratory exercise for neuroscience majors. The journal of undergraduate Neuroscience Education 3 2 (2005) A36-A41 [Spring]
21. D'Astous M., Morissette M., Tanguay B., Callier S., and Di Paolo T. Dehydroepiandrosterone (DHEA) such as 17beta-estradiol prevents MPTP-induced dopamine depletion in mice. Synapse 47 (2003) 10-14
22. Ellman G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 82 (1959) 70-77
23. Elkashef A.M., and Wyatt J. Tardive dyskinesia: possible involvement of free radicals and treatment with vitamin E. Schizophr Bull 25 (1997) 731-740
24. Exposito I., Del Arco A., Segovia G., and Mora F. Endogenous dopamine increases extracellular concentrations of glutamate and GABA in striatum of the freely moving rat: involvement of D1 and D2 dopamine receptors. Neurochem Res 24 7 (1999) 849-856
25. Frye C.A., and Vongher J.M. Progesterone and 3α, 5α-THP enhances sexual receptivity in mice. Behav Neurosci 115 (2001) 1118-1128
26. Frye C.A., Scalise T.J., and Bayon L.E. Finasteride blocks the reduction in actual activity produced by exogenous estrous cyclicity. J Neuroendocrinol 10 (1998) 291-296
27. Gerlach J., and Casey D.E. Tardive dyskinesia. Acta Psychiatr Scand 77 (1988) 369-378
28. Gerlach J., Reys T., and Kristjansen P. Effect of baclofen on tardive dyskinesia. Psychopharmacology 56 (1978) 145-151
29. Gunne L.M., Haggestrom J.E., and Sjokvist B. Association with persistent neuroleptic induced dyskinesia of regional changes in the brain GABA synthesis. Nature 309 (1984) 347-349
30. Kajta M., Budziszewska B., and Lason W. Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells. Pol J Pharmacol 51 6 (1999) 531-534
31. Kato J., Hirata S., Nozawa A., and Yamada-Mouri N. Gene expression of progesterone receptor isoforms in the rat brain. Horm Behav 28 (1994) 454-463
32. Kokate T.G., Banks M.K., Magee T., Yamaguchi S., and Rogawski M.A. Finasteride, a 5α-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. J Pharmacol Exp Ther 288 (1999) 679-684
33. Kono Y. Generation of superoxide radical during auto-oxidation of hydroxylamine and an assay of superoxide dismutase. Arch Biochem Biophy 186 (1978) 189-195
34. A receptors. Prog Neurobiol 71 (2003) 67-80
35. Lockhart E.M., Warner D.S., Pearlstein R.D., Penning D.H., and Mehrabani Boustany R.M. Allopregnanolone attenuates N-methyl-d-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. Neurosci Lett 328 1 (2002) 33-36
36. Lowry O.H., Rosenbrought N.J., Farr A.L., and Randall R.J. Protein measurements with the Folin-phenol reagent. J Biol Chem 193 (1951) 265-275
37. Luck H. Catalase spectrophotometric method. In: Bergmeyer HU, editor. Methods in Enzymatic analysis. Newyork: Academic press; (1963)
38. Mani S.K., Blaustein J.D., and O'Malley B.W. Progesterone receptor functions from a behavioral perspective. Horm Behav 31 (1997) 244-255
39. Naidu P.S., Singh A., and Kulkarni S.K. Carvedilol attenuates neuroleptic-induced orofacial dyskinesia: possible antioxidant mechanisms. Br J Pharmacol 136 2 (2002) 193-200
40. Naidu P.S., Singh A., and Kulkarni S.K. Quercetin, a bioflavonoid attenuated haloperidol induced orofacial dyskinesia. Neuropharmacology 44 (2003) 1100-1106
41. Ossowska K. Neuronal basis of neuroleptic induced extrapyramidal side effects. Pol J Pharmacol 54 (2002) 299-312
42. Oztekin E., Baltaci A.K., Tiftik A.M., and Mogulkoc R. Lipid peroxidation in ovariectomized and pinealectomized rats: the effects of estradiol and progesterone supplementation. Cell Biochem Funct 25 5 (2007) 551-554 (Sept.-Oct.)
43. Pastoris A., Cerutti L., Sacco R., De Vecchi L., and Sbaffi A. Automated analysis of urinary catecholamines by high-performance liquid chromatography and on-line sample pretreatment. J Chromatogr B Biomed Appl 664 2 (1995) 287-293
44. Peixoto M.F., Abilio V.C., Silva R.H., and Frussa-Filho R. Effects of valproic acid on an animal model of tardive dyskinesia. Behav Brain Res 142 (2003) 229-233
45. Peixoto M.F., Araujo N.P., Silva R.H., Castro J.P., Fukushiro D.F., Faria R.R., et al. Effects of gabaergic drugs on reserpine-induced oral dyskinesia. Behav Brain Res 160 1 (2005) 51-59
46. Reddy D.S. Is there a physiological role of the neurosteroid THDOC in stress-sensitive conditions?. Trends Pharmacol Sci 24 (2003) 103-106
47. Reddy D.S., Castaneda D.C., O'Malley B.W., and Rogawski M.A. Seizure resistance of progesterone receptor knockout mice. FASEB J 15 (2001) A223-A223
48. Reddy D.S., Castaneda D.C., O'Malley B.W., and Rogawski M.A. Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice. J Pharmacol Exp Ther 310 (2004) 230-239
49. Seiler N., Grauffel C., Elands J., Van den Buuse M., Knodgen B., Sarhan S., et al. Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. Pharmacol Biochem Behav 50 (1995) 181-189
50. Shivakumar B.R., and Ravindranath V. Oxidative stress and thiol modification induced by chronic administration of haloperidol. J Pharmacol Exp Ther 265 3 (1993) 1137-1141
51. Silva R.H., Abílio V.C., Torres-Leite D., Bergamo M., Chinen C.C., Claro F.T., Carvalho Rde C., and Frussa-Filho R. Concomitant development of oral dyskinesia and memory deficits in reserpine-treated male and female mice. Behav Brain Res 132 2 (2002) 171-177
52. Singh A., Naidu P.S., and Kulkarni S.K. Possible antioxidant and neuroprotective mechanisms of FK506 in attenuating haloperidol-induced orofacial dyskinesia. Eur J Pharmacol 477 2 (2003) 87-94
53. A receptors. Proc Natl Acad Sci U S A 100 (2003) 14439-14444
54. Thaker G.K., Nguyen A.J., and Tamminga C.A. Increased saccadic distractibility in tardive dyskinesia: functional evidence for subcortical GABA dysfunction. Biol Psychiatry 1 (1988) 49-59
55. Thaker G.K., Nguyen J.A., Strauss M.E., Jacobson R., Kaup B.A., and Tamminga C.A. Clonazepam treatment of tardive dyskinesia: a practical GABA mimetic strategy. Am J Psychiatry 147 (1990) 445-451
56. Tsai G., Goff D.C., Chang R.W., Flood J., Baer L., and Coyle J.T. Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. Am J Psychiatry 155 9 (1998) 1207-1213
57. Van Os J., Walsh E., van Horn E., Tattan T., Bale R., and Thompson S.G. Tardive dyskinesia in psychosis: are women really more at risk? UK700 Group. Acta Psychiatr Scand 99 4 (1999) 288-293
58. Wills E.D. Mechanism of lipid peroxide formation in animal tissues. Biochem J 99 (1966) 667-676
59. Yu R., Xu X.H., and Sheng M.P. Differential effects of allopregnanolone and GABA on kainate-induced lactate dehydrogenase release in cultured rat cerebral cortical cells. Acta Pharmacol Sin 23 8 (2002) 680-684