Dehydroepiandrosterone (DHEA) such as 17β-estradiol prevents MPTP-induced dopamine depletion in mice

Synapse

Volumn 47, Issue 1, 2003, Pages 10-14

  D'Astous, Myreille ^a,b   Morissette, Marc ^a,b   Tanguay, Bastien ^a,b   Callier, Sophie ^a,b   Di Paolo, Thérèse ^a,b,c  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c NONE   (Canada)

Author keywords

Catecholamine; DOPAC; Estrogen; HVA; Neuroprotection; Neurosteroid; Parkinson

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 3,4 DIHYDROXYPHENYLACETIC ACID; CATECHOLAMINE; DOPAMINE; DOPAMINE TRANSPORTER; ESTRADIOL; HOMOVANILLIC ACID; MESSENGER RNA; NEUROSTEROID; PRASTERONE; SODIUM CHLORIDE; TYROSINE 3 MONOOXYGENASE; CARRIER PROTEIN; DOPAMINE RECEPTOR STIMULATING AGENT; MEMBRANE PROTEIN; NERVE PROTEIN; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATECHOLAMINE DEPLETION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DRUG EFFECT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN SITU HYBRIDIZATION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA; TURNOVER TIME; ANIMAL; C57BL MOUSE; METABOLISM;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; 3,4-DIHYDROXYPHENYLACETIC ACID; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CORPUS STRIATUM; DEHYDROEPIANDROSTERONE; DOPAMINE; DOPAMINE AGENTS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; ESTRADIOL; HOMOVANILLIC ACID; IN SITU HYBRIDIZATION; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEUROPROTECTIVE AGENTS; SUBSTANTIA NIGRA; TYROSINE 3-MONOOXYGENASE;

EID: 0037207530     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.10145     Document Type: Article

References (37)

1. Bastianetto S, Ramassamy C, Poirier J, Quirion R. 1999. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res Mol Brain Res 66:35-41.
2. Baulieu EE. 1998. Neurosteroids: A novel function of the brain. Psychoneuroendocrinology 23:963-987.
3. Baulieu EE, Robel P. 1998. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci USA 95:4089-4091.
4. Behl C, Holsboer F. 1999. The female sex hormone oestrogen as a neuroprotectant. Trends Pharmacol Sci 20:441-444.
5. Behl C, Widmann M, Trapp T, Holsboer F. 1995. 17-Beta estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem Biophys Res Commun 216:473-482.
6. Behl C, Skutella T, Lezoualc'h F, Post A, Widmann M, Newton CJ, Holsboer F. 1997. Neuroprotection against oxidative stress by estrogens: Structure-activity relationship. Mol Pharmacol 51:535-541.
7. Bélanger A, Candas B, Dupont A, Cusan L, Diamond P, Gomez JL, Labrie F. 1994. Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year old men. J Clin Endocrinol Metab 79:1086-1090.
8. Bergeron R, de Montigny C, Debonnel G. 1996. Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: Effects mediated via sigma receptors. J Neurosci 16:1193-1202.
9. Brinton RD, Tran J, Proffitt P, Montoya M. 1997. 17 Beta-estradiol enhances the outgrowth and survival of neocortical neurons in culture. Neurochem Res 22:1339-1351.
10. Callier S, Morissette M, Grandbois M, Di Paolo T. 2000. Stereospecific prevention by 17beta-estradiol of MPTP-induced dopamine depletion in mice. Synapse 37:245-251.
11. Calon F, Birdi S, Rajput AH, Hornykiewicz O, Bédard PJ, Di Paolo T. 2002. Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias. J Neuropathol Exp Neurol 61:186-196.
12. Cardounel A, Regelson W, Kalimi M. 1999. Dehydroepiandrosterone protects hippocampal neurons against neurotoxin-induced cell death: Mechanism of action. Proc Soc Exp Biol Med 22:145-149.
13. Compagnone NA, Mellon SH. 1998. Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci USA 95:4678-4683.
14. Di Paolo T, Bedard P, Daigle M, Boucher R. 1986. Long-term effects of MPTP on central and peripheral catecholamine and indoleamine concentrations in monkeys. Brain Res 379:286-293.
15. Dluzen DE, McDermott JL, Liu B. 1996. Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice. Neurotoxicol Teratol 18:603-606.
16. Emmerson PJ, Clark MJ, Medzihradsky F, Remmers AE. 1999. Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy. J Neurochem 73:289-300.
17. Franklin K, Paxinos G. 1997. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic Press.
18. Grandbois M, Morissette M, Callier S, Di Paolo T. 2000. Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice. Neuroreport 11:343-346.
19. Kimonides VG, Khatibi NH, Svendsen CN, Sofroniew MV, Herbert J. 1998. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc Natl Acad Sci USA 95:1852-1857.
20. Labrie F. 1991. Intracrinology. Mol Cell Endocrinol 78:C113-118.
21. Labrie C, Flammand M, Bélanger A, Labrie F. 1996. High bioavailability of dehydroepiandrosterone administered percuteneoulsy in the rat. J Endocrinol 150:S107-S118.
22. Laflamme N, Nappi RE, Drolet G, Labrie C, Rivest S. 1998. Expression and neuropeptidergic characterization of estrogen receptors (ERalpha and ERbeta) throughout the rat brain: Anatomical evidence of distinct roles of each subtype. J Neurobiol 36:357-378.
23. Lapchak PA, Chapman DF, Nunez SY, Zivin JA. 2000. Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: Possible involvement of GABA(A) receptors. Stroke 31:1953-1956; discussion 1957.
24. Lowry O, Rosebrough N, Farr A, Randall R. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-270.
25. Mao X, Barger SW. 1998. Neuroprotection by dehydroepiandrosterone-sulfate: Role of an NFkappaB-like factor. Neuroreport 9:759-763.
26. Marx CE, Jarskog LF, Lauder JM, Gilmore JH, Lieberman JA, Morrow AL. 2000. Neurosteroid modulation of embryonic neuronal survival in vitro following anoxia. Brain Res 871:104-112.
27. Mensah-Nyagan AG, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H. 1999. Neurosteroids: Expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system. Pharmacol Rev 51:63-81.
28. Miller DB, Ali SF, O'Callaghan JP, Laws SC. 1998. The impact of gender and estrogen on striatal dopaminergic neurotoxicity. Ann NY Acad Sci 844:153-165.
29. Morales AJ, Nolan JJ, Nelson JC, Yen SSC. 1994. Effects of replacement dose of dehydroepiandrosterone in men and women of advaneing age. J Steroid Biochem 9:1360-1367.
30. Morissette M, Dicko A, Pezolet M, Callier S, Di Paolo T. 1999. Effect of dehydroepiandrosterone and its sulfate and fatty acid ester derivatives on rat brain membranes. Steroids 64:796-803.
31. Murray HE, Gillies GE. 1997. Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures. J Neuroendocrinol 9:287-295.
32. Rivest R, Falardeau P, Di Paolo T. 1995. Brain dopamine transporter: Gender differences and effect of chronic haloperidol. Brain Res 692:269-272.
33. Sawada H, Shimohama S. 2000. Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons. Neurosci Biobehav Rev 24:143-147.
34. Sousa A, Ticku MK. 1997. Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site. J Pharmacol Exp Ther 282:827-833.
35. Steiner H, Bonner TI, Zimmer AM, Kitai ST, Zimmer A. 1999. Altered gene expression in striatal projection neurons in CB1 cannabinoid receptor knockout mice. Proc Natl Acad Sci USA 96:5786-5790.
36. Tsutsui K, Ukena K, Usui M, Sakamoto H, Takase M. 2000. Novel brain function: Biosynthesis and actions of neurosteroids in neurons. Neurosci Res 36:261-273.
37. Wolf OT, Kirschbaum C. 1999. Actions of dehydroepiandrosterone and its sulfate in the central nervous system: Effects on cognition and emotion in animals and humans. Brain Res Brain Res Rev 30:264-288.