Increased hepatic Δ6-desaturase activity with growth hormone expression in the MG101 transgenic mouse

Lipids

Volumn 31, Issue 2, 1996, Pages 139-143

  Nakamura, Manabu T ^a,c   Phinney, Stephen D ^a,b   Tang, Anna B ^b   Oberbauer, Anita M ^a   German, J Bruce ^a   Murray, James D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; CHOLESTEROL ESTER; GROWTH HORMONE; LIPID; LIVER ENZYME; PHOSPHOLIPID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GROWTH REGULATION; LEAN BODY WEIGHT; LIPID COMPOSITION; LIVER; MOUSE; NONHUMAN; STRUCTURAL GENE; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; OVIS;

EID: 0029671157     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02522612     Document Type: Article

References (31)

1. Pursei, V.G., Rexroad, C.E., and Bolt, D.J. (1988) Gene Transfer for Enhanced Growth of Livestock, in Animal Growth Regulation (Campion, D.R., Hausman, G.J., and Martin, R.J., eds.) pp. 359-375, Plenum Publishing, New York.
2. Shanahan, C.M., Rigby. N.W., Murray, J.D., Marshall, M.T., Townrow, C.A., Nancarrow, C.D., and Ward, K.A. (1989) Regulation of Expression of a Sheep Metallothionein la-Sheep Growth Hormone Fusion Gene in Transgenic Mice, Molec. Cell. Biol. 9, 5473-5479.
3. Pomp, D., Nancarrow, C.D., Ward, K.A., and Murray, J.D. (1992) Growth, Feed Efficiency and Body Composition of Transgenic Mice Expressing a Sheep Metallothionein 1a-Sheep Growth Hormone Fusion, Livestock Production Sci. 31, 335-350.
4. Hooghe, R., Delhase, M., Vergani, P., Malur, A., and Hooghe-Peters, E. L. (1993) Growth Hormone and Prolactin Are Paracrine Growth and Differentiation Factors in the Haemotopoietic System, Immunology Today 14, 212-214.
5. Maddaiah, V.T., and Clejan, S. (1986) Growth Hormone and Liver Mitochondria: Time Course of Effects on Respiration and Fatty Acid Composition in Hypophysectomized Rats, Endocrinology 119, 250-252.
6. Murray, J.D., Oberbauer, A.M., Sharp, K.R., and German, J.B. (1994) Expression of an Ovine Growth Hormone Transgene in Mice Increases Arachidonic Acid in Cellular Membranes, Transgenic Research 3, 241-248.
7. Searle, T.W., Murray, J.D., and Baker, P.J. (1992) Effect of Increased Production of Growth Hormone on Body Composition in Mice - Transgenic Versus Control, J. Endocrinol. 132, 285-291.
8. Pomp, D., Murray, J.D., and Medrano, J.F. (1991) Single Day Detection of Transgenic Mice by PCR of Toe Clips, Mouse Genome. 89, 279.
9. Oberbauer, A.M., Currier, T.A., Nancarrow, C.D.. Ward, K.A., and Murray, J.D. (1992) Linear Bone Growth of oMT1a-oGH Transgenic Male Mice, Am. J. Physiol. 262, 936-942.
10. Nakamura, M.T., Tang A.B., Villanueva, J., Halsted, C.H., and Phinney, S.D. (1994) Selective Reduction of Δ6 and Δ5 Desaturase Activities But Not Δ9 Desaturase in Micropigs Chronically Fed Ethanol, J. Clin. Invest. 93, 450-454.
11. Markwell, M.K., Haas, S.M., Tolbert, N.E., and Bieber, L.L. (1981) Protein Determination in Membrane and Lipoprotein Samples: Manual and Automated Procedures, Methods Enzymol. 72, 296-297.
12. Nakamura, M.T., Tang A.B., Villanueva, J., Halsted, C.H., and Phinney, S.D. (1992) Reduced Tissue Arachidonic Acid Concentration with Chronic Ethanol Feeding in Miniature Pigs, Am. J. Clin. Nutr. 56, 467-74.
13. Brenner, R.R. (1989) Factors Influencing Fatty Acid Chain Elongation and Desaturation, in The Role of Fats in Human Nutrition, 2nd edn. (Vergroesen, A.J., and Crawford, M., eds.) pp. 45-79, Academic Press, San Diego.
14. Doglio, A., Dani, C., Grimaldi, P., and Ailhaud, G. (1986) Growth Hormone Regulation of the Expression of Differentiation-Dependent Genes in Preadipocyte Ob 1771 Cells, Biochem. J. 238, 123-129.
15. Rincon-Limas, D.E., Resendez-Perez, D., Ortiz-Lopez, R., Alvidrez-Quihui, L.E., Castro-Munozledo, F., Kuri-Harcuch, W., and Martinez-Rodriguez, H.G. (1993) HGH Isoforms: cDNA Expression, Adipogenic Activity and Production in Cell Culture, Biochim. Biophys. Acta 1172, 49-54.
16. Flint, D.J., and Gardner, M.J. (1993) Influence of Growth Hormone Deficiency on Growth and Body Composition in Rats: Site-Specific Effects upon Adipose Tissue Development, J. Endocrinol. 157, 203-211.
17. Tanner, J.W., Leingang, K.A., Mueckler, M.M., and Glenn, K.C. (1992) Cellular Mechanism of the Insulin-Like Effect of Growth Hormone in Adipocytes. Rapid Translocation of the HepG2-Type and Adipocyte/Muscle Glucose Transporters, Biochem. J. 282, 99-106.
18. Dietz, J., and Schwartz, J. (1991) Growth Hormone Alters Lipolysis and Hormone-Sensitive Lipase Activity in 3T3-F442A Adipocytes, Metabolism 40, 800-806.
19. Salomon, F., Cuneo, R.C., Hesp, R., and Sonksen , P.H. (1989) The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency, N. Eng. J. Med. 321, 1793-1803.
20. Moller, J., Jorgensen, J.O.L., Moller, N., Christiansen, J.S., and Weeke, J. (1992) Effects of Growth Hormone Administration on Fuel Oxidation and Thyroid Function in Normal Man, Metabolism 41, 728-731.
21. Schoenle, E.J., Quing, Q.R., and Zachmann, M. (1990) Growth Hormone Requirement for a Normal Human Adipocyte Glucose Carrier Function, J. Clin. Endocrinol. Metab. 70, 1674-1677.
22. Gaillard, D., Negrel, R., Lagarde, M., and Ailhaud, G. (1989) Requirement and Role of Arachidonic Acid in the Differentiation of Pre-Adipose Cells, Biochem. J. 257, 389-397.
23. Negrel, R., Gaillard, D., and Ailhaud, G. (1989) Prostacyclin as a Potent Effector of Adipose-Cell Differentiation, Biochem. J. 257, 399-405.
24. 2α inhibits Early and Late Markers of Differentiation in the Adipogenic Cell Line 1246, Endocrinology 131, 2545-2551.
25. Pelikanova, T., Kohout, M., Valek, J., Base, J., and Kazdova, L. (1989) Insulin Secretion and Insulin Action Related to the Serum Phospholipid Fatty Acid Pattern in Healthy Men, Metabolism 38, 188-192.
26. Borkman, M., Storlien, L.H., Pan, D.A., Jenkins, A.B., Chisholm, D.J., and Campbell, L.V. (1993) The Relation Between Insulin Sensitivity and the Fatty Acid Composition of Skeletal Muscle Phospholipids, N. Eng. J. Med. 328, 238-244.
27. Clarke, S., and Jump, D. (1994) Dietary Polyunsaturated Fatty Acid Regulation of Gene Transcription, Ann. Rev. Nutr. 14, 83-98.
28. Jurivich, D., Sistonen, L., Sarge, K., and Morimoto, R. (1993) Arachidonate Is a Potent Modulator of Human Heat Shock Gene Transcription, Proc. Natl. Acad. Sci. 91, 2280-2284.
29. Thams, P., Hedeskov, C., and Capito, K. (1993) Exogenous Arachidonic Acid Inactivates Protein Kinase C in Mouse Pancreatic Islets, Acta. Physiol. Scand. 149, 227-235.
30. Kinsella, J., Lokesh, B., Broughton, S., and Whelan, J. (1990) Dietary Polyunsaturated Fatty Acids and Eicosanoids: Potential Effects on the Modulation of Inflammatory and Immune Cells, J. Nutr. 6, 24-44.
31. Lee, T.H., Hoover, R.L., William, J.D., Sperling, R.I., Raralese, J., Spur, B.W., Robinson, D.R., Corey, E.J., Lewis, R.A., and Austen, K.F. (1985) Effect of Dietary Enrichment with Eicosapentaenoic and Docosahexaenoic Acids on in vitro Neutrophil and Monocyte Leucotriene Generation and Neutrophil Function, N. Engl. J. Med. 312, 1217-1224.