Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons

Neuropharmacology

Volumn 54, Issue 4, 2008, Pages 629-639

  Liu, Boyi ^a   Zhang, Xuan ^a   Wang, Chuan ^a   Zhang, Guohong ^a   Zhang, Hailin ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Diphenhydramine; Excitability; KCNQ M channel; Membrane potential; Mepyramine; SCG neuron

Indexed keywords

ANTIHISTAMINIC AGENT; DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR; MEPYRAMINE; PHOSPHOLIPASE C; POTASSIUM CHANNEL KCNQ;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CERVICAL GANGLION; CONTROLLED STUDY; DATA ANALYSIS; DEPOLARIZATION; DRUG OVERDOSE; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; NERVE CELL; NERVE CELL EXCITABILITY; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; POTASSIUM CURRENT; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; DIPHENHYDRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; HISTAMINE H1 ANTAGONISTS; HUMANS; INDOLES; KCNQ POTASSIUM CHANNELS; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; PYRILAMINE; RATS; RATS, SPRAGUE-DAWLEY; SUPERIOR CERVICAL GANGLION; TRANSFECTION;

EID: 38749086448     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2007.11.012     Document Type: Article

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