The radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) reacts with a pterin derivative and produces a cytotoxic substance that induces intracellular reactive oxygen species generation and cell death

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 2, 2008, Pages 529-538

  Arai, Toshiyuki ^a   Nonogawa, Mitsuru ^b   Makino, Keisuke ^b   Endo, Nobuyuki ^c   Mori, Hiroko ^d   Miyoshi, Takashi ^a   Yamashita, Kouhei ^a   Sasada, Masataka ^b   Kakuyama, Masahiro ^a   Fukuda, Kazuhiko ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c WAKASA WAN ENERGY RESEARCH CENTER   (Japan)

^d Higashiyama Takeda Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (N,N DIMETHYLAMINOMETHYLENEAMINO) 6 FORMYL 3 PIVALOYLPTERIDINE 4 ONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; NORPHENAZONE; PTERIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; OXYGEN CONSUMPTION; PANCREAS CANCER; PRIORITY JOURNAL;

ANTIPYRINE; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CYTOTOXINS; FREE RADICAL SCAVENGERS; HUMANS; INTRACELLULAR FLUID; PTERINS; REACTIVE OXYGEN SPECIES;

EID: 38749083380     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.131391     Document Type: Article

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