Screening and diagnosis of Cushing's syndrome

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 51, Issue 8, 2007, Pages 1191-1198

  De Castro, Margaret ^a   Moreira, Ayrton C ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Circadian rhythm; Cushing's syndrome; Dexamethasone suppression; Hypercortisolism; Salivary cortisol; Urinary free cortisol

Indexed keywords

EID: 38649128490     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/s0004-27302007000800004     Document Type: Review

References (55)

1. Orth DN. Cushing's syndrome. N Engl J Med 1995;332:791-803.
2. Newell-Price J, Trainer P, Besser GM, Grossman AB. The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocr Rev 1998;19:647-72.
3. Atkinson AB, McCance DR, Kennedy L, Sheridan B. Cyclical Cushing's syndrome first diagnosed after pituitary surgery: a trap for the unwary. Clin Endocrinol 1992;36:297-379.
4. Arnaldi G, Mancini T, Kola B, Appolloni G, Freddi S, Concettoni C, et al. Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. J Clin Endocrinol Metab 2003;88:5834-40.
5. Gunther DF, Bourdeau I, Matyakhina L, Cassarino D, Kleiner DE, Griffin K, et al. Cyclical Cushing syndrome presenting in infancy: an early form of primary pigmented nodular adrenocortical disease, or a new entity? J Clin Endocrinol Metab 2004;89:3173-82.
6. Arnaldi G, Angeli A, Atkinson AB, Bertagna X, Cavagnini F, Chrousos GP, et al. Diagnosis and complications of Cushing's syndrome: a consensus statement. J Clin Endocrinol Metab 2003;88:5593-602.
7. Leibowitz G, Tsur A, Chayen SD, Salameh M, Raz I, Cerasi E. Pre-clinical Cushing's syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients. Clin Endocrinol 1996;44:717-22.
8. Contreras LN, Cardoso E, Lozano MP, Pozzo J, Pagano P, Claus-Hermbeg H. Deteccion de sindrome de Cushing precl?nico en pacientes con sobrepeso y diabetes mellitas tipo 2. Medicina 2000;60:326-30.
9. Reincke M, Nieke J, Krestin GP, Saeger W, Allolio B, Winkelmann W. Preclinical Cushing's syndrome in adrenal "incidentalomas": comparison with adrenal Cushing's syndrome. J Clin Endocrinol Metab 1992;75:826-32.
10. Terzolo M, Pia A, Ali A, Osella G, Reimondo G, Bovio S. Adrenal incidentaloma: a new cause of the metabolic syndrome? J Clin Endocrinol Metab 2002;87:998-1003.
11. Catargi B, Rigalleau V, Poussin A, Ronci-Chaix N, Bex V, Vergnot V, et al. Occult Cushing's syndrome in type-2 diabetes. J Clin Endocrinol Metab 2003;88:5808-13.
12. Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing's syndrome. Lancet 2006;367(9522):1605-17.
13. Kaye TB, Crapo L. The Cushing syndrome: an update on diagnostic tests. Ann Intern Med 1990;112:434-44.
14. Boscaro M, Barzon L, Sonino N. The diagnosis of Cushing's syndrome: atypical presentations and laboratory shortcomings. Arch Intern Med 2000;160:3045-53.
15. Murphy BE. Urinary free cortisol determinations: what they measure. Endocrinologist 2002;12:143-50.
16. Turpeinen U, Markkanen H, Valimaki M, Stenman UH. Determination of urinary free cortisol by HPLC. Clin Chem 1997;43:1386-91.
17. Lin CL, Wu TJ, Machacek DA, Jiang NS, Kao PC. Urinary free cortisol and cortisone determined by high performance liquid chromatography in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 1997;82:151-5.
18. Findling JW, Raff H. Newer diagnostic techniques and problems in Cushing's disease. Endocrinol Metab Clin North Am 1999;28:191-210.
19. Gorges R, Knappe G, Gerl H, Ventz M, Stahl F. Diagnosis of Cushing's syndrome: re-evaluation of midnight plasma cortisol vs. urinary free cortisol and low-dose dexamethasone suppression test in a large patient group. J Endocrinol Invest 1999;22:241-9.
20. Viardot A, Huber P, Puder JJ, Zulewski H, Keller U, Muller B. Reproducibility of nighttime salivary cortisol and its use in the diagnosis of hypercortisolism compared with urinary free cortisol and overnight dexamethasone suppression test. J Clin Endocrinol Metab 2005;90:5730-6.
21. Papanicolaou DA, Yanovski JA, Cutler GB, Chrousos GP, Nieman LK. A single midnight cortisol measurement distinguishes Cushing's syndrome from pseudo-Cushing's states. J Clin Endocrinol Metab 1998;83:1163-7.
22. Papanicolaou DA, Mullen N, Kyrou I, Nieman LK. Nighttime salivary cortisol: a useful test for the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 2002;87:455-521.
23. Findling JW, Raff H. Cushing's Syndrome: important issues in diagnosis and management. J Clin Endocrinol Metab 2006;91:3746-53.
24. Liddle GW. Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome. J Clin Endocrinol Metab 1960;20:1539-60.
25. Isidori AM, Kaltsas GA, Mohammed S, Morris DG, Jenkins P, Chew SL. Discriminatory value of the low-dose dexamethasone suppression test in establishing the diagnosis and differential diagnosis of Cushing's syndrome. J Clinical Endocrinol Metab 2003;88:5299-306.
26. Odagiri E, Naruse M, Terasaki K, Yamaguchi N, Jibiki K, Takagi S, et al. The diagnostic standard of preclinical Cushing's syndrome: evaluation of the dexamethasone suppression test using various cortisol kits. Endocrine J 2004;51:295-302.
27. Chriguer RS, Elias LL, da Silva IM Jr, Vieira JG, Moreira AC, de Castro M. Glucocorticoid sensitivity in young healthy individuals: in vitro and in vivo studies. J Clin Endocrinol Metab 2005;90:5978-84.
28. Crapo L. Cushing's syndrome: a review of diagnostic tests. Metabolism 1979;28:955-77.
29. Findling JW, Raff H, Aron DC. The low-dose dexamethasone suppression test: a reevaluation in patients with Cushing's syndrome. J Clin Endocrinol Metab 2004;89:1222-6.
30. Newell-Price J, Trainer P, Perra L, Wass J, Grossman A, Besser M. A single sleeping midnight cortisol has 100% sensitivity for the diagnosis of Cushing's syndrome. Clin Endocrinol 1995;43:545-50.
31. Putignano P, Toja P, Dubini A, Pecori Giraldi F, Corsello SM, Cavagnini F. Midnight salivary cortisol versus urinary free and midnight serum cortisol as screening tests for Cushing's syndrome. J Clin Endocrinol Metab 2003;88:4153-7.
32. Reimondo G, Allasino B, Bovio S, Paccotti P, Angeli A, Terzolo M. Evaluation of the effectiveness of midnight serum cortisol in the diagnostic procedures for Cushing's syndrome. Eur J Endocrinol 2005;153:803-9.
33. Giraldi FP, Ambrogio AG, De Martin M, Fatti LM, Scacchi M, Cavagnini F. Specificity of first-line tests for the diagnosis of Cushing's syndrome. Assessment in a large series. J Clin Endocrinol Metab 2007;[Epub ahead of print]
34. Walker RF, Riad-Fahmy D, Read GF. Adrenal status assessed by direct radioimmunoassay of cortisol in whole saliva or parotid saliva. Clin Chem 1978;24:1460-3.
35. Umeda T, Hiramatsu R, Iwaoka T, Shimada T, Miura F, Sato T. Use of saliva for monitoring unbound free cortisol levels in serum. Clin Chim Acta 1981;110:245-53.
36. Santiago LB, Jorge SM, Moreira AC. Longitudinal evaluation of the development of salivary cortisol circadian rhythm in infancy. Clin Endocrinol 1996;44:157-61.
37. Luthold WW, Marcondes JAM, Wajchenberg BL. Salivary cortisol for the evaluation of Cushing's syndrome. Clin Chim Acta 1985;151:33-9.
38. Laudat MH, Cerdas S, Fournier C, Guiban D, Guilhaume B, Luton JP. Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function. J Clin Endocrinol Metab 1988;66:343-8.
39. Raff H, Raff JL, Findling JW. Late-night salivary cortisol as a screening test for Cushing's syndrome. J Clin Endocrinol Metab 1998;83:2681-6.
40. Castro M, Elias PCL, Quidute ARP, Halah FP, Moreira AC. Outpatient screening for Cushing's syndrome: the sensitivity of the combination of circadian rhythm and overnight dexamethasone suppression salivary cortisol tests. J Clin Endocrinol Metab 1999;84:878-82.
41. Trilck M, Flitsch J, Ludecke DK, Jung R, Petersenn S. Salivary cortisol measurement - a reliable method for the diagnosis of Cushing's syndrome. Exp Clin Endocrinol Diabetes 2005;113:225-30.
42. Yaneva M, Mosnier-Pudar H, Dugue M-A, Grabar S, Fulla Y, Bertagna X. Midnight salivary cortisol for the initial diagnosis of Cushing's syndrome of various causes. J Clin Endocrinol Metab 2004;89:3345-51.
43. Martinelli CE, Sader SL, Oliveira EB, Daneluzzi JC, Moreira AC. Salivary cortisol for screening of Cushing's syndrome in children. Clin Endocrinol 1999;51:67-71.
44. Gafni RI, Papanicolaou DA, Nieman LK. Nighttime salivary cortisol measurement as a simple, noninvasive, outpatient screening test for Cushing's syndrome in children and adolescents. J Pediatr 2000;137:30-5.
45. Liu H, Bravata DM, Cabaccan J, Raff H, Ryzen E. Elevated late-night salivary cortisol levels in elderly male type 2 diabetic veterans. Clin Endocrinol 2005;63:642-9.
46. Raff H, Homar PJ, Skoner DP. New enzyme immunoassay for salivary cortisol [Letter]. Clin Chem 2003;49:203-4.
47. Raff H, Homar PJ, Burns EA. Comparison of two methods for measuring salivary cortisol [Letter]. Clin Chem 2002;48:207-8.
48. Chiu SK, Collier CP, Clark AF, Wynn-Edwards KE. Salivary cortisol on ROCHE Elecsys immunoassay system: pilot biological variation studies. Clin Biochem 2003;36:211-4.
49. Baid SK, Sinaii N, Wade M, Rubino D, Nieman LK. Radioimmunoassay and tandem mass spectrometry measurement of bedtime salivary cortisol levels: a comparison of assays to establish hypercortisolism. J Clin Endocrinol Metab 2007;92:3102-7.
50. Vogeser M, Durner J, Seliger E, Auernhammer C. Measurement of late-night salivary cortisol with an automated immunoassay system. Clin Chem Lab Med 2006;44:1441-5.
51. Yanovski JA, Cutler GB Jr., Chrousos GP, Nieman LK. Corticotropin- releasing hormone stimulation following low-dose dexamethasone administration. JAMA 1993;269:2232-8.
52. Yanovski JA, Cutler GB Jr., Chrousos GP, Nieman LK. The dexamethasone suppressed corticotropin-releasing hormone stimulation test differentiates mild Cushing's disease from normal physiology. J Clin Endocrinol Metab 1998;83:348-52.
53. Duclos M, Corcuff J-B, Rober P, Tabarin A. The dexamethasone-suppressed corticotrophin-releasing hormone stimulation test in anorexia nervosa. Clin Endocrinol 1999;51:725-31.
54. Coiro V, Volpi R, Capretti L, Caffarri G, Chiodera P. Desmopressin and hexarelin tests in alcohol-induced pseudo-Cushing's syndrome. J Intern Med 2000;247:667-73.
55. Moro M, Putignano P, Losa M, Invitti C, Maraschini C, Cavagnini F. The desmopressin test in the differential diagnosis between Cushing's disease and pseudo-Cushing states. J Clin Endocrinol Metab 2000;85:3569-74.