Effect of hemin and carbon monoxide releasing molecule (CORM-3) on cGMP in rat penile tissue

Journal of Sexual Medicine

Volumn 5, Issue 2, 2008, Pages 336-343

  Abdel Aziz, M Talaat ^a   El asmar, M Farid ^b   Mostafa, Taymour ^a   Atta, Hazem ^a   Fouad, Hanan H ^a   Roshdy, Nagwa K ^a   Rashed, Laila A ^a   Obaia, Eman A ^a   Sabry, Dina A ^b   Abdel Aziz, Ahmed T ^a   Drummond, George ^c   Olszanecki, Rafal ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b AIN SHAMS UNIVERSITY   (Egypt)

^c NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

cGMP; CO; Corpus cavernosum; Erectile dysfunction; HO 1; HO 2; NO

Indexed keywords

AGENTS ACTING ON THE GENITAL SYSTEM; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE 3; CYCLIC GMP; HEME OXYGENASE 1; HEME OXYGENASE 2; HEMIN; MESOPORPHYRIN TIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG SCREENING; ENZYME ACTIVITY; MALE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TISSUE LEVEL; UPREGULATION; VASODILATATION; WESTERN BLOTTING;

EID: 38649121434     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2007.00695.x     Document Type: Article

References (45)

1. Latini DM, Penson DF, Wallace KL, Lubeck DP, Lue TF. Longitudinal differences in psychological outcomes for men with erectile dysfunction: Results from ExCEED. J Sex Med 2006;3:1068-76.
2. Latini DM, Penson DF, Wallace KL, Lubeck DP, Lue TF. Clinical and psychosocial characteristics of men with erectile dysfunction: Baseline data from ExCEED. J Sex Med 2006;3:1059-67.
3. Laumann EO, West S, Glasser D, Carson C, Rosen R, Kang JH. Prevalence and correlates of erectile dysfunction by race and ethnicity among men aged 40 or older in the United States: From the male attitudes regarding sexual health survey. J Sex Med 2007;4:57-65.
4. Craven PA, De Rubertis FR. Restoration of the responsiveness of purified guanylate cyclase to nitrosoguanidine, nitric oxide and related activators by heme and hemeproteins. Evidence for involvement of the paramagnetic nitrosyl-heme complex in enzyme activation. J Biol Chem 1978;253:8433-43.
5. Burnett AL. Nitric oxide in the penis-science and therapeutic implications from erectile dysfunction to priapism. J Sex Med 2006;3:578-82.
6. Ignarro LJ, Wood KS, Wolin MS. Regulation of purified soluble guanylate cyclase by porphyrins and metalloporphyrins: A unifying concept. Adv Cyclic Nucleotide Protein Phosphorylation Res 1984;17:267-74.
7. Stone JR, Marletta MA. Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 1994;33:5636-40.
8. Zakhary R, Poss KD, Jaffrey SR, Ferris CD, Tonegawa S, Snyder SH. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. Proc Natl Acad Sci 1997;94:14848-53.
9. Rich A, Farrugia G, Rae JL. Carbon monoxide stimulates a potassium selective current in rabbit corneal epithelial cells. Am J Physiol 1994;267:C435 -42.
10. Sammut IA, Foresti R, Clark JE, Exon DJ, Vesely MJ, Sarathchandra P, Green CJ, Motterlini R. Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1. Br J Pharmacol 1998;125:1437-44.
11. Wang R, Wang Z, Wu L. Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 1997;121:927-34.
12. Abdel-Aziz MT, El-Asmar MF, Mostafa T, Atta H, Abdel Aziz M, Fouad H, Rashed L, Roshdy N. Effects of nitric oxide synthase and heme oxygenase inducers and inhibitors on molecular signaling of erectile function. Clin Biochem Nutr (Japan) 2005;37:103-11.
13. Hedlund P, Ny L, Alm P, Andersson KE. Cholinergic nerves in human corpus cavernosum and spongiosum contain nitric oxide synthase and heme oxygenase. J Urol 2000;164:868-75.
14. Qiao L, Xin ZC. Advances in the research about penile erection related genes. Zhonghua Nan Ke Xue 2002;8:363-6.
15. Wang J, Lu S, Moenne-Loccoz P, Ortiz de Montellano PR. Interaction of nitric oxide with human heme oxygenase-1. Biol Chem 2003;278:2341-7.
16. Baranano DE, Snyder SH. Neural roles for heme oxygenase: Contrasts to nitric oxide synthase. Proc Natl Acad Sci 2001;98:10996-1002.
17. Abraham NG, Quan S, Mieyal PA, Yang L, Burke-Wolin T, Mingone CJ, Goodman AI, Nasjletti A, Wolin MS. Modulation of cGMP by human HO-1 retrovirus gene transfer in pulmonary microvessel endothelial cells. Am J Physiol Lung Cell Mol Physiol 2002;283:L1117-24.
18. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: Characterization of biochemical and vascular activities. Circ Res 2002;90:E17-E24.
19. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 2003;93:E2-E8.
20. Di Pascoli M, Rodella L, Sacerdoti D, Bolognesi M, Turkseven S, Abraham NG. Chronic CO levels has a beneficial effect on vascular relaxation in diabetes. Biochem Biophys Res Commun 2005;340:935-43.
21. Ahmad M, Turkseven S, Mingone CJ, Gupte SA, Wolin MS, Abraham NG. Heme oxygenase-1 gene expression increases vascular relaxation and decreases inducible nitric oxide synthase in diabetic rats. Cell Mol Biol 2005;51:371-6.
22. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidium thiocyanate-phenol-cholroform extraction. Anal Biochem 1987;162:156-60.
23. Hoshida S, Nishida M, Yamashita N, Igarashi J, Aoki K, Hori M, Kuzuya T, Tada M. Heme oxygenase-1 expression and its relation to oxidative stress during primary culture of cardiomyocytes. J Mol Cell Cardiol 1996;28:1845-55.
24. Mingone CJ, Gupte SA, Quan S, Abraham NG, Wolin MS. Influence of heme and heme oxygense-1 transfection of pulmonary microvascular endothelialium on oxidant generation and cGMP. Exp Biol Med (Maywood) 2003;228:535-9.
25. Abdel-Aziz TM, El-Asmar MF, Atta H, Shaker O, Fouad H, Hosni H, etal. Effect of inducers of heme oxygenase-1 on eicosanoids, cAMP, cGMP levels in rat endothelial cells. Biochimica Clinica 2002;26:352-7.
26. Cirino G, Sorrentino R, di Villa Bianca R, Popolo A, Palmieri A, Imbimbo C, Fusco F, Longo N, Tajana G, Ignarro LJ, Mirone V. Involvement of beta 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Proc Natl Acad Sci 2003;100:5531-6.
27. Angulo J, Cuevas P, Fernandez A, Gabancho S, Allona A, Martin-Morales A, Moncada I, Saenz De Tejada I. Activation and potentiation of the NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing. Br J Pharmacol 2003;138:63-70.
28. Abraham NG, Lutton JD, Levere RD. Heme metabolism and erythropoiesis in abnormal iron states. Role of aminolevulinic acid synthetase and heme oxygenase. Exp Haematol 1985;13:833-43.
29. Chitaley K, Wingard CJ, Clinton Webb R, Branam H, Stopper VS, Lewis RW, Mills TM. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001;7:119-22.
30. Toda N, Okamura T. The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol Rev 2003;55:271-324.
31. Xue L, Farrugia G, Miller MS, Ferris CD, Snyder SH, Szurszewski JH. Carbon monoxide and nitric oxide as coneurotransmitters in the entric nervous system: Evidence from genomic deletion of biosynthetic enzymes. Proc Natl Acad Sci USA 2000;97:1851-5.
32. Ushiyama M, Kuramochi T, Katayama S. Treatment with hypotensive agents affects the impaired relaxation of the penile corpus cavernosum in hypertensive rats. Hypertens Res 2006;29:523-32.
33. Ushiyama M, Morita T, Kuramochi T, Yagi S, Katayama S. Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res 2004;27:253-61.
34. Shamloul R, Wang R. Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. J Sex Med 2006;3:619-27.
35. 2+ sensitivity by cyclic nucleotides in smooth muscles from protein kinase G-deficient mice. J Biol Chem 2004;279:5146-51.
36. Kaide JI, Zhang F, Wei Y, Jiang H, Yu C, Wang WH, Balazy M, Abraham NG, Nasjletti A. Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors. J Clin Invest 2001;107:1163-71.
37. Friebe A, Schultz G, Koesling D. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO J 1996;15:6863-8.
38. Cary SP, Marletta MA. The case of CO signaling: Why the jury is still out. J Clin Invest 2001;107:1071-3.
39. Colpaert EE, Timmermans JP, Lefebvre RA. Investigation of the potential modulatory effect of biliverdin, carbon monoxide and bilirubin on nitrergic neurotransmission in the pig gastric fundus. Eur J Pharmacol 2002;457:177-86.
40. Marks GS, Brien JF, Nakatsu K. What role does the heme-heme oxygenase-carbon monoxide system play in vasoregulation? Am J Physiol Regul Integr Comp Physiol 2003;285:R522-3.
41. Tayem Y, Johnson TR, Mann BE, Green CJ, Motterlini R. Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule. Am J Physiol Renal Physiol 2006;290:F789 -94.
42. Ryter SW, Morse D, Choi AM. Carbon monoxide: To boldly go where nitric oxide has gone before. Sci STKE 2004;20:RE6.
43. Abdel Aziz MT, El-Asmer MF, Mostafa T, Mostafa S, Atta H, Wassef MA, Fouad H, Rashed L, Sabry D, Mahfouz S. Heme oxygenase versus nitric oxide synthase in signalling mediating sildenafil citrate action. J Sex Med 2007;4:1098-107.
44. Abdel Aziz MT, Mostafa T, Atta H, Rashed L, Marzouk SA, Obaia EM, Sabry D, Hassouna AA, El-Shehaby AM, Abdel Aziz AT. Oral phosphodiesterase-5 inhibitors: Effect of heme oxygenase inhibition on cGMP signaling in rat cavernous tissue. Andrologia 2007;39:66-70.
45. Abdel Aziz MT, El-Asmer MF, Mostafa T, Atta H, Rashed L, Sabry D, Ashour S, Abdel Aziz AT. Assessment of heme oxygenase-1 (HO-1) activity in the cavernous tissues of sildenafil citrate-treated rats. Asian J Androl 2007;9:377-81.