Expression of p16INK4A gene in human pituitary tumours

Pituitary

Volumn 11, Issue 1, 2008, Pages 71-75

  Machiavelli, Gloria ^a   Cotignola, Javier ^a   Danilowicz, Karina ^a   Carbonara, Carolina ^a   Paes de Lima, Andrea ^a   Basso, Armando ^a   Bruno, Oscar Domingo ^a   Szijan, Irene ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

p16INK4AmRNA; Pituitary adenomas; Reverse transcription PCR

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA;

ACTH SECRETING ADENOMA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER DIAGNOSIS; CARCINOGENESIS; CLINICAL ARTICLE; ELECTROPHORESIS; FEMALE; GROWTH HORMONE SECRETING ADENOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPOPHYSIS TUMOR; MALE; MICROADENOMA; PRIORITY JOURNAL; PROLACTINOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROTROPIN SECRETING ADENOMA;

ADENOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PITUITARY NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 38649105153     PISSN: 1386341X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11102-007-0077-z     Document Type: Article

References (19)

1. Faglia G (1993) Epidemiology and pathogenesis of pituitary adenomas. Acta Endocrinol 129(Suppl):1-5
2. Mindermann T, Wilson CB (1994) Age-related and gender-related occurrence of pituitary adenomas. Clin Endocrinol 41:359-64
3. Farrell WE, Simpson DJ, Bicknell J, Magnay JL, Kyrodimou E, Thakker RV, Clayton RN (1999) Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours. Br J Cancer 80:44-50
4. Boikos SA, Stratakis CA (2006) Carney complex: Pathology and molecular genetics. Neuroendocrinology 83(3-4):189-99
5. Daly AF, Jaffrain-Rea ML, Ciccarelli A, et al (2006) Clinical characterization of familial isolated pituitary adenomas. J Clin Endocrinol Metab 91:3316-23
6. Frost SJ, Simpson DJ, Clayton RN, Farrell WE (1999) Transfection of an inducible p16/CDKN2A construct mediated reversible growth inhibition and G1 arrest in the AtT20 pituitary tumour cell line. Mol Endocrinol 13:1801-1810
7. Angaard L, Lukas J, Bartkova J, Kjerulff A, Strauss M, Bartek J (1995) Aberrations of the p16 and retinoblastoma tumour-suppressor genes occur in distinct subsets of human cancer cell lines. Int J Cancer 61:115-120
8. Szijan I, Orlow I, Dalamon V, Vergani P, Danilowicz K, Mezzadri N, Cordon-Cardo C, Bruno OD (2000) Alterations in the retinoblastoma pathway of cell cycle control in parathyroid tumors. Oncol Rep 7:421-5
9. Woloschak M, Yu A, Xiao J, Post KD (1996) Frequent loss of the P16 INK4a gene product in human pituitary tumours. Cancer Res 56:2493-2496
10. Ogino A, Yoshino Katayama Y, Watanabe T, Ota T, Komine Ch, Yokoyama T, Fukushima T (2005) The p15 INK4b/p16 INK4a/RB1 pathway is frequently deregulated in human pituitary adenomas. J Neuropathol Exp Neurol 64:398-403
11. Jaffrain-Rea ML, Ferretti E, Toniato E, Cannita K, Santoro A, Di Stefano D, Ricevuto E, Maroder M, Tamburrano G, Cantore G, Gulino A, Martinotti S. (1999) p16 (INK4A,MTS-1) gene polymorphisms, methylation status in human pituitary tumours. Clin Endocrinol 51:317-325
12. Simpson DJ, Bicknell JE, McNicol AM, Clayton RN, Farrell WE (1999) Hypermethylation of the p16/CDKN2A/MTS1 gene and loss of protein expression is associated with non-functional pituitary adenomas but not somatotropinomas. Genes Chrom Cancer 24:328-336
13. Seemann N, Kuhn D, Wrocklage C, Keyvani K, Hackl W, Buchfelder M, Fahlbusch R, Paulus W (2001) CDKN2A/p16 inactivation is related to pituitary adenoma type and size. J Pathol 193:491-497
14. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyannate-phenol-chloroform extraction. Anal Biochem 161:156-159
15. Farrell WE, Clayton RN (1998) Molecular genetics of pituitary tumours. Trends Endocrinol Metab 9(1):20-26
16. Zhang X, Horwitz GA, Heaney AP, Nakashima M, Prezant TR, Bronstein MD, Melmed S (1999) Pituitary tumour transforming gene (PTTG) expression in pituitary adenomas. J Clin Endocrinol Metab 84:761-767
17. Jacks T, Fazelli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA (1992) Effect of an Rb mutation in mouse. Nature (Lond.) 359:295-300
18. Serrano M, Hannon GJ, Beach D (1993) A new regulatory motif in cell-cycle control causing specific ingibition of cyclin D/CDK4. Nature (Lond.) 366:704-707
19. Cryns VL, Alexander JM, Klibanski A, Arnold A (1993) The retinoblastoma gene in human pituitary tumours. J Clin Endocrinol Metab 77:644-646