Sequence analysis and transcript expression of the MEN1 gene in sporadic pituitary tumours

British Journal of Cancer

Volumn 80, Issue 1-2, 1999, Pages 44-50

  Farrell, W E ^a   Simpson, D J ^a   Bicknell, J ^a   Magnay, J L ^a   Kyrodimou, E ^a,c   Thakker, R V ^b   Clayton, R N ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c G GENNIMATAS GENERAL HOSPITAL   (Greece)

Author keywords

Loss of heterozygosity; MEN1; Menin transcript; Pituitary tumours

Indexed keywords

ARTICLE; CHROMOSOME 11Q; CLINICAL ARTICLE; DNA POLYMORPHISM; EXON; GENE DELETION; GENE EXPRESSION; GENE LOCUS; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPOPHYSIS TUMOR; INTRON; MULTIPLE ENDOCRINE NEOPLASIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

CHROMOSOMES, HUMAN, PAIR 11; DNA, NEOPLASM; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; NEOPLASM PROTEINS; PITUITARY NEOPLASMS; POLYMORPHISM, GENETIC; PROTO-ONCOGENE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; SEQUENCE ANALYSIS, DNA;

EID: 0032953078     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690319     Document Type: Article

References (39)

1. Agarwal SK, Kester MB, Debelenko LV, Heppner C, Emmert-Buck MR, Skarulis MC, Doppman JL, Kim YS, Lubensky IA, Zhengping Z, Green JS, Guru SC, Manickam P, Olufemi S-E, Liotta LA, Chandrasekarappa SC, Collins FS, Spiegal AM, Lee Burns A and Marx SJ (1997) Germline mutations of the MENI gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet 6: 1169-1175
2. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A and Klibanski A (1990) Clinically non-functioning pituitary tumors are monoclonal in origin. J Clin Invest 86: 336-340
3. Bassett JHD, Forbes SA, Pannett AAJ, Lloyd SE, Christie PT, Wooding C, Harding B, Besser GM, Monson JP, Sampson J, Wass AH, Wheeler MH and Thakker RV (1998) Characterization of mutations in patients with multiple endocrine neoplasia type 1. Am J Hum Genet 62: 232-244
4. Bates AS, Farrell WE, Bicknell EJ, Talbot AJ, Broome JC, Perrett CW, Thakker RV and Clayton RN (1997) Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J Clin Endocrinol Metab 82: 818-824
5. Boggild MD, Jenkinson S, Pistorello M, Boscaro M, Scanarini M, McTernan, Perret CW, Thakker RV and Clayton RN (1994) Molecular genetic studies of sporadic pituitary tumours. J Clin Endocrinol Metab 78: 387-392
6. Bystrom C, Larsson C, Blomberg C, Sandelin K, Falkmer E, Skogseid B, Oberg K, Werner S and Nordenskjold M (1990) Localisation of the MENI gene to a small region within chromosome 11q13 by deletion mapping in tumours. Proc Natl Acad Sci USA 87: 1968-1972
7. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi S-E, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agerwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegal Am, Burns AL and Marx SJ (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404-407
8. Chomczynski P and Sacchi N (1987) Single step method of RNA isolation by acid guanidine thiocyanate extraction. Anal Biochem 162: 156-159
9. Clementi E, Malgaretti N, Meldolesi J and Taramelli R (1990) A new constitutively activating mutation in G protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene 5: 1059-1061
10. Cryns V, Alexander JM, Klibanski A and Arnold A (1993) The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab 77: 644-646
11. Debelenko LV, Zhuang Z, Emmert-Buck MR, Chandrasekharappa SC, Manickam P, Guru SC, Marx Sj, Skarulis MC, Spiegal AM, Collins FS, Jenson RT, Liotta LA and Lubensky IA (1997) Allelic deletion on chromosome 11q13 in MENI-associated and sporadic gastrinomas and pancreatic endocrine tumours. Cancer Res 57: 2238-2243
12. Dong Q, Debelenko LV, Chadrasekharappa SC, Emmert-Buck MR, Zhuang Z, Guru SC, Manickam P, Skarulis M, Lubensky IA, Liotta LA, Collins FS, Marx SJ and Spiegal AM (1997) Loss of heterozygosity at 11q13: analysis of pituitary tumours, lung carcinoids, lipomas and other uncommon tumours in subjects with familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 82: 1416-1420
13. European Consortium on MENI (1997a) Identification of the multiple endocrine neoplasia type 1 (MENI) gene. Hum Mol Genet 6: 1177-1183
14. European Consortium on MENI (1997b) Construction of a 1.2Mb sequence ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MENI) gene. Genomics 44: 94-100
15. Farrell WE, Simpson DJ, Bicknell J, McNicol AM, Clayton RN (1997a) Methylation of the tumour supressor gene (TSG) CDKN2/MTS1 occurs frequently in invasive and non-invasive pituitary adenomas and is associated with loss of p16 expression. Mutation Detection 4th International Workshop; Human Genome Organisation, Brno Czech Republic. (abstract): 25
16. Farrell WE, Simpson D, Bates AS, Talbot JA, Bicknell J and Clayton RN (1997b) Chromosome 9 p deletions in invasive and non invasive non-functional pitutary adenomas: The deleted region involves markers outside of the MTS1 and MTS2 gene. Cancer Res 57: 2703-2709
17. Friedman E, DE Marco L, Gejman PV, Norton JA, Bale AE, Aurbach GD, Spiegal AM and Marx SJ (1992) Allelic loss from chromosome 11 in parathyroid tumours. Cancer Res 52: 6804-6809
18. Heppner C, Kester MB, Agarwal SK, Debelenko LV, EmmertBuck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alender RH, Kim YS, Saggar SK, Lubensky IA, Zhuang ZP, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL and Marx SJ (1997) Somatic mutations of the MENI gene in parathyroid tumours. Nature Gen 16: 375-378
19. Herman V, Fagin J, Gonsky R, Kovaks K and Melmed S (1990) Clonal origin of pituitary adenomas. J Clin Endocrinol Metab 71: 1427-1433
20. Jakobovitz O, Nass D, DeMarco L, Barbosa AJA, Simoni FB, Rechavi G and Friedman (1996) Carcinoid tumours frequently display genetic abnormalities involving chromosome 11. J Clin Endocrinol Metab 81: 3164-3167
21. s and stimulate adenyl cyclase in human pituitary tumours. Nature 340: 692-696
22. Lida A, Blake K, Tunny T, Klemm S, Stowasser M, Hayward N, Gordon R, Nakamura Y and Imai T (1995) Allelic losses on chromosome band 11q13 in aldosterone-producing adrenal tumours. Genes Chromosomes Cancer 12: 73-75
23. Lyons J, Landis CA, Harsh G, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh QY, Clarke OH, Kawasaki E, Bourne HR and McCormick (1990) Two G protein oncogenes in human endocrine tumours. Science 249: 655-659
24. Manickam P, Guru SC, Debelenko LV, Agarwal SK, Olufemi S-E, Weisemann JM, Boguski MS, Crabtree JS, Wang YP, Roe BA, Lubensky IA, Zhuang ZP, Kester MB, Burns AL, Spiegel AM, Marx SJ, Liotta LA, EmmertBuck MR, Collins FS and Chandrasekharappa SC (1997) Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MENI) region. Hum Genet 101: 102-108
25. Melmed S (1994) Pituitary neoplasia. In: Multiple Endocrine Neoplasia, Gagel RF (ed). Endocrinol Metab Clinics North Am 23: 81-92
26. Pei L, Melmed S, Scheithauer B, Kovaks K, Benedict WE and Prager D (1995) Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumour supressor gene other than RB. Cancer Res 55: 644-646
27. Pei L and Melmed S (1996) Oncogenes and tumour suppressor genes in pituitary tumorigenesis. In Oncogenesis and Molecular Biology of Pituitary Tumours, Melmed S (ed) Front Horm Res 20: 122-136
28. Prezant TR, Levine J and Melmed S (1998) Molecular characterization of the MENI tumour suppressor gene in sporadic pituitary tumors. J Clin Endocrinol Metab (in press)
29. Simpson DJ, Bicknell JE, McNicol AM, Clayton RN, Farrell WE (1999) Hypermethylation of the p16/CDKN2A/MTS1 gene and loss of protein expression is associated with non-functional pituitary adenomas but not somatotrophinomas. Genes, Chromosomes Cancer 24: 328-336
30. Shimon I and Melmed S (1997) Genetic basis of endocrine disease: pituitary tumor pathogeneis. J Clin Endocrinol Metab 82: 1675-1681
31. Sumi T, Stefaneanu L, Kovaks K, Asa S and Rindi G (1993) Immunohistochemical study of p53 protein in human and animal pituitary tumours. Endocrinol Pathol 4: 95-99
32. Thakker RV (1993) The molecular genetics of the multiple endocrine neoplasia syndrome. Clin Endocrinol 38: 1-14
33. Thakker RV (1996) Role of chromosome 11 in hereditary and sporadic pituitary tumourigenesis. In Front Hormone Research, Melmed S (ed). Basel, Karger. 20: 179-193
34. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M and Clayton RN (1993) Association of somatotrophinomas with loss of alleles on chromosome 11 with gsp mutations. J Clin Invest 91: 2815-2821
35. INK4a gene product in human pituitary tumours. Cancer Res 56: 2493-2486
36. Woloschak M, Yu A and Post KD (1997) Frequent inactivation of the p16 gene in human pituitary tumours by gene methylation. Mol Carcinogen 19: 221-224
37. Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG and Black PM (1994) Human pituitary adenomas show no loss of herozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab 78: 922-927
38. Zhuang ZP, Vortmeyer AO, Pack S, Huang S, Pham TA, Wang CY, Park WS, Agarwal SK, Debelenko LV, Kester M, Guru SC, Manickam P, Olufemi SE, Yu F, Heppner C, Crabtree JS, Skarulis MC, Venzon DJ, EmmertBuck MR, Spiegel AM, Chandrasekhrapper SC, Collins FS, Burns AL, Marx SJ, Jensen RT, Liotta LA and Lubensky (1997a) Somatic mutations of the MENI tumour suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res 57: 4682-4686
39. Zhuang Z, Ezzat SZ, Vortmeyer AO, Weil R, Oldfield EH, Park SP, Pack S, Huang S, Agarwal SK, Guru SC, Manickam P, Debelenko LV, Kester MB, Olufemi SE, Heppner C, Crabtree JS, Burns AL, Spiegel AM, Marx SJ, Chandrasekharappa SC, Collins FS, Emmert-Buck MR, Liotta LA, Asa SL and Lubensky IA, Walker LM, Holm A, Oberg A, Sundqvist T, El Haj AJ (1997b) Mutation of the MENI tumour suppressor gene in pituitary tumours. Cancer Res 57: 5446-5451