Molecular genetics of pituitary tumours

Trends in Endocrinology and Metabolism

Volumn 9, Issue 1, 1998, Pages 20-26

  Farrell, William E ^a   Clayton, Richard N ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME 10Q; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 9P; GENE LOCUS; GENE MAPPING; HUMAN; HYPOPHYSIS TUMOR; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

EID: 0031916973     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(98)00006-X     Document Type: Article

References (59)

1. Agarwal SK, Kester MB, Debelenko LVet al. Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. Hum Mol Genet. 7:1997;1169-1175.
2. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A Clinically non-functional pituitary tumours are monoclonal in origin. J Clin Invest. 86:1990;336-340.
3. Bates AS, Farrell WE, Bicknell EJet al. Allelic deletion in pituitary adenomas reflects aggressive biological activity and has potential value as a prognostic marker. J Clin Endocrinol Metab. 82:1997;818-824.
4. Battifora H p53 immunohistochemistry: a word of caution. Hum Pathol. 25:1994;435-436.
5. Bertherat J, Chanson P, Montminy M The cyclic adenosine 3′5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol. 9:1995;777-783.
6. Boggild MD, Jenkinson S, Pistorello Met al. Molecular genetic studies of sporadic pituitary tumours. J Clin Endocrinol Metab. 78:1994;387-392.
7. Borreli E, Sawchenco PE, Evans RM Pituitary hyperplasia induced by ectopic expression of nerve growth factor. Proc Natl Acad Sci USA. 89:1992;2764-2768.
8. Buckley N, Bates AS, Broome JCet al. p53 protein accumulation in Cushing's adenoma and invasive non functional adenomas. J Clin Endocrinol Metab. 79:1994;1513-1516.
9. Bystrom C, Larsson C, Blomberg Cet al. Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA. 87:1990;1968-1972.
10. Chandrasekharappa SC, Guru SC, Manickam Pet al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science. 276:1997;404-407.
11. s protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene. 5:1990;1059-1061.
12. Cryns VL, Alexander JM, Klibanski A, Arnold A The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab. 77:1993;644-646.
13. Dahia PLM, Aguiar RCT, Honneger J, Fahlbusch R, Besser GM, Grossman AB Investigation of the cell cycle regulator p27/kip1 gene in ACTH-secreting tumours: lack of correlation with the 'knockout' animal model. J Endocrinol. 152(Suppl):1997;202.
14. q gene (GNAQ) and a processed pseudogene. Genomics. 30:1995;470-475.
15. s or thyrotropin-releasing hormone receptor genes. J Clin Endocrinol Metab. 81:1996;1134-1140.
16. q in invasive non-functional pituitary adenomas. Clin Endocrinol. 47:1997;241-244.
17. Farrell WE, Simpson D, Bates AS, Talbot JA, Bicknell J, Clayton RN Chromosome 9p deletions in invasive and non-invasive non-functional pitutary adenomas: the deleted region involves markers outside of the MTS1 and MTS2 gene. Cancer Res. 57:1997;2703-2709.
18. Farrell WE, Simpson DJ, Bicknell J, McNicol AM, Clayton RN Methylation of the tumour supressor gene (TSG) CDKN2/MTS1 occurs frequently in invasive and non-invasive pituitary adenomas and is associated with loss of p16 expression [abst]. HUGO Mutation Detection 4th International Workshop. Brno, Czech Republic. 1997:1997;25.
19. Fearon ER, Vogelstein B A genetic model for colorectal tumorigenesis. Cell. 61:1990;759-767.
20. Heppner C, Kester MB, Agarwal SKet al. Somatic mutations of the MEN1 gene in parathyroid tumours. Nat Genet. 16:1997;375-378.
21. Herman V, Fagin J, Gonsky R, Kovaks K, Melmed S Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 71:1990;1427-1433.
22. Herman V, Drazin NZ, Gonsky R, Melmed S Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab. 77:1993;50-55.
23. Herman-Bonert V, Fagin JV Molecular pathogenesis of pituitary tumours. Baillière's Clin Endocrinol Metab. 9:1995;203-223.
24. Δ20/+ mice are predisposed to tumours of the pituitary gland with nearly complete penetrance. Oncogene. 9:1994;1021-1027.
25. Jacks T, Fazelli A, Schmitt E, Bronson RT, Goodell M, Weinberg RA Effect of an Rb mutation in mouse. Nature. 359:1992;295-300.
26. kip1 expression in nontumorous and neoplastic human pituitaries. Am J Pathol. 151:1997;509-519.
27. Jones P Methylation errors and cancer. Cancer Res. 56:1996;2463-2467.
28. Kamb A, Gruis NA, Weaver-Feldhaus Jet al. A cell cycle regulator potentially involved in the genesis of many tumor types. Science. 264:1994;436-440.
29. Kennedy SM, MacGeogh C, Jaffe R, Spurr NK Overexpression of the oncoprotein p53 in primary hepatic tumours of childhood does not correlate with gene mutations. Hum Pathol. 25:1994;438-442.
30. Knudson AG Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 68:1971;820-823.
31. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340:1989;692-696.
32. Lemmens I, VandeVen WJM, Kas Ket al. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. Hum Mol Genet. 6:1997;1177-1183.
33. Levine AJ, Perry ME, Chang Aet al. The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor in tumorigenesis. Br J Cancer. 69:1994;409-416.
34. Levy A, Hall S, Yeudall WA, Lightman SL p53 gene mutations in pituitary adenoma: rare events. Clin Endocrinol. 41:1994;809-814.
35. Lyons J, Landis CA, Harsh Get al. Two G protein oncogenes in human endocrine tumors. Science. 249:1990;655-659.
36. Makos M, Nelkin BD, Reiter REet al. Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors. Cancer Res. 53:1993;2719-2722.
37. McAndrews J, Paterson AJ, Asa SL, McCarthy KJ, Kudlow JE Targeting of transforming growth factor-α expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology. 136:1995;4479-4488.
38. Melmed S Pituitary neoplasia. Endocrin Metab Clinics North Am. 23:1994;81-92.
39. Missale C, Boroni F, Losa Met al. Nerve growth factor suppresses the transforming phenotype of human proactinomas. Proc Natl Acad Sci USA. 90:1993;7961-7965.
40. Missale C, Losa M, Sigala S, Balsari A, Giovanneli M, Spano PF Nerve growth factor controls proliferation and progression of human prolactinoma cell lines through an autocrine mechanism. Mol Endocrinol. 10:1996;272-285.
41. kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumours. Cell. 85:1996;707-720.
42. Pei L, Melmed S Oncogenes and tumour suppressor genes in pituitary tumorigenesis. Front Horm Res. 20:1996;122-136.
43. Pei L, Melmed S Isolation and characterization of pituitary tumor-transforming gene (PTTG). Mol Endocrinol. 11:1997;433-441.
44. Pei L, Melmed S, Scheitayer B, Kovaks K, Prager D H-ras mutations in human pituitary carcinoma metastases. J Clin Endocrinol Metab. 78:1994;842-846.
45. Pei L, Melmed S, Scheithauer B, Kovaks K, Benedict WE, Prager D Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumour supressor gene other than RB. Can Res. 55:1995;644-646.
46. Shimon L, Melmed S Genetic basis of endocrine disease. J Clin Endocrinol Metab. 82:1997;1675-1681.
47. Sumi T, Stefaneanu L, Kovaks K, Asa S, Rindi G Immunohistochemical study of p53 protein in human and animal pituitary tumours. Endocrinol Pathol. 4:1993;95-99.
48. Takino H, Herman V, Weiss M, Melmed S Purine binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. J Clin Endocrinol Metab. 80:1995;1733-1738.
49. Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. J Clin Endocrinol Metab. 82:1997;3141-3147.
50. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. J Clin Invest. 91:1993;2815-2821.
51. Thapar K, Scheithauer BW, Kovaks K, Pernicone PJ, Laws ER p53 expression in pituitary adenomas and carcinomas: correlation with invasiveness and tumour growth fractions. Neurosurgery. 38:1996;765-771.
52. Thapar K, Kovaks K, Stefaneanu Let al. Overexpression of the growth-hormone-releasing hormone gene in acromegaly-associated pituitary tumours. Am J Pathol. 151:1997;769-784.
53. s α-gene in nonfunctioning pituitary tumours. J Clin Endocrinol Metab. 77:1993;765-769.
54. α mutations in clinically non-functioning pituitary tumours. Clin Endocrinol. 41:1994;815-820.
55. Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE G protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. Eur J Clin Invest. 25:1995;128-131.
56. Woloschak M, Roberts JL, Post KD Loss of heterozygosity at the retinoblastoma gene locus in human pituitary tumors. Cancer. 74:1994;693-696.
57. INK4a gene product in human pituitary tumours. Cancer Res. 56:1996;2493-2496.
58. Woloschak M, Yu A, Post KD Frequent inactivation of the p16 gene in human pituitary tumours by gene methylation. Mol Carcinogen. 19:1997;221-224.
59. Zhu J, Leon SP, Beggs AH, Busque L, Gilliland DG, Black PM Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab. 78:1994;922-927.