Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake

Journal of Molecular Medicine

Volumn 86, Issue 2, 2008, Pages 211-220

  Yea, Kyungmoo ^a   Kim, Jaeyoon ^a   Lim, Seyoung ^a   Park, Ho Seon ^b   Park, Kyong Soo ^b   Suh, Pann Ghill ^a   Ryu, Sung Ho ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

Diabetes; Glucose lowering; Glucose uptake; Lysophosphatidic acid

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLUCOSE TRANSPORTER 4; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHATIDIC ACID;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL SURFACE; CONTROLLED STUDY; DOSE RESPONSE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; IMMUNOBLOTTING; INSULIN RELEASE; MALE; MOUSE; MYOTUBE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; BLOOD GLUCOSE; CELL MEMBRANE; CHROMONES; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; INSULIN; ISOXAZOLES; LYSOPHOSPHOLIPIDS; MALE; MICE; MICE, INBRED ICR; MORPHOLINES; MUSCLE FIBERS; PERTUSSIS TOXIN; PHOSPHORYLATION; PROPIONIC ACIDS; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LYSOPHOSPHATIDIC ACID;

EID: 38649086101     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-007-0269-z     Document Type: Article

References (35)

1. Rajala MW, Scherer PE (2003) Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144:3765-3773
2. Bourey RE, Koranyi L, James DE, Mueckler M, Permutt MA (1990) Effects of altered glucose homeostasis on glucose transporter expression in skeletal muscle of the rat. J Clin Invest 86:542-547
3. Moller DE (2001) New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414:821-827
4. Hutchinson DS, Bengtsson T (2005) Alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway. Endocrinology 146:901-912
5. Perrini S, Natalicchio A, Laviola L, Belsanti G, Montrone C, Cignarelli A, Minielli V, Grano M, De Pergola G, Giorgino R, Giorgino F (2004) Dehydroepiandrosterone stimulates glucose uptake in human and murine adipocytes by inducing GLUT1 and GLUT4 translocation to the plasma membrane. Diabetes 53:41-52
6. Elmendorf JS (2002) Signals that regulate GLUT4 translocation. J Membr Biol 190:167-174
7. Wu-Wong JR, Berg CE, Wang J, Chiou WJ, Fissel B (1999) Endothelin stimulates glucose uptake and GLUT4 translocation via activation of endothelin ETA receptor in 3T3-L1 adipocytes. J Biol Chem 274:8103-8110
8. Kishi K, Muromoto N, Nakaya Y, Miyata I, Hagi A, Hayashi H, Ebina Y (1998) Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway. Diabetes 47:550-558
9. Tigyi G, Miledi R (1992) Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J Biol Chem 267:21360-21367
10. Goetzl EJ, An S (1998) Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J 12:1589-1598
11. Sengupta S, Wang Z, Tipps R, Xu Y (2004) Biology of LPA in health and disease. Semin Cell Dev Biol 15:503-512
12. Luquain C, Sciorra VA, Morris AJ (2003) Lysophosphatidic acid signaling: how a small lipid does big things. Trends Biochem Sci 28:377-383
13. Aoki J, Taira A, Takanezawa Y, Kishi Y, Hama K, Kishimoto T, Mizuno K, Saku K, Taguchi R, Arai H (2002) Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem 277:48737-48744
14. Valet P, Pages C, Jeanneton O, Daviaud D, Barbe P, Record M, Saulnier-Blache JS, Lafontan M (1998) Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. J Clin Invest 101:1431-1438
15. Ferry G, Tellier E, Try A, Gres S, Naime I, Simon MF, Rodriguez M, Boucher J, Tack I, Gesta S, Chomarat P, Dieu M, Raes M, Galizzi JP, Valet P, Boutin JA, Saulnier-Blache JS (2003) Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. J Biol Chem 278:18162-18169
16. Simon MF, Daviaud D, Pradere JP, Gres S, Guigne C, Wabitsch M, Chun J, Valet P, Saulnier-Blache JS (2005) Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem 280:14656-14662
17. Contos JJ, Fukushima N, Weiner JA, Kaushal D, Chun J (2000) Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A 97:13384-13389
18. Van den Berghe N, Ouwens DM, Maassen JA, van Mackelenbergh MG, Sips HC, Krans HM (1994) Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes. Mol Cell Biol 14:2372-2377
19. Wang Q, Khayat Z, Kishi K, Ebina Y, Klip A (1998) GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay. FEBS Lett 427:193-197
20. Wijesekara N, Tung A, Thong F, Klip A (2006) Muscle cell depolarization induces a gain in surface GLUT4 via reduced endocytosis independently of AMPK. Am J Physiol Endocrinol Metab 290:E1276-1286
21. Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH (2002) Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. J Biol Chem 277:6542-6549
22. Spiegel S, Milstien S (1995) Sphingolipid metabolites: members of a new class of lipid second messengers. J Membr Biol 146:225-237
23. Xu Y (2002) Sphingosylphosphorylcholine and lysophosphatidylcholine: G protein-coupled receptors and receptor-mediated signal transduction. Biochim Biophys Acta 1582:81-88
24. Contos JJ, Ishii I, Chun J (2000) Lysophosphatidic acid receptors. Mol Pharmacol 58:1188-1196
25. 507-534
26. Noguchi K, Ishii S, Shimizu T (2003) Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278:25600-25606
27. Ishii I, Fukushima N, Ye X, Chun J (2004) Lysophospholipid receptors: signaling and biology. Annu Rev Biochem 73:321-354
28. An S, Bleu T, Hallmark OG, Goetzl EJ (1998) Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273:7906-7910
29. Im DS, Heise CE, Harding MA, George SR, O'Dowd BF, Theodorescu D, Lynch KR (2000) Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol Pharmacol 57:753-759
30. Yanagida K, Ishii S, Hamano F, Noguchi K, Shimizu T (2007) LPA4/p2y9/GPR23 mediates Rho-dependent morphological changes in a rat neuronal cell line. J Biol Chem 282:5814-5824
31. Ohta H, Sato K, Murata N, Damirin A, Malchinkhuu E, Kon J, Kimura T, Tobo M, Yamazaki Y, Watanabe T, Yagi M, Sato M, Suzuki R, Murooka H, Sakai T, Nishitoba T, Im DS, Nochi H, Tamoto K, Tomura H, Okajima F (2003) Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol Pharmacol 64:994-1005
32. Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806
33. Richter EA, Derave W, Wojtaszewski JF (2001) Glucose, exercise and insulin: emerging concepts. J Physiol 535:313-322
34. Astrup A, Finer N (2000) Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'? Obes Rev 1:57-59
35. Despres JP, Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444:881-887