Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease

European Journal of Gastroenterology and Hepatology

Volumn 14, Issue 10, 2002, Pages 1061-1066

  Heinzlmann, Maria ^a   Lang, Susanne M ^a   Neynaber, Sven ^a   Reinshagen, Max ^a   Emmrich, Joerg ^a   Stratakis, Diana F ^a   Heldwein, Walter ^a   Wiebecke, Baldur ^a   Loeschke, Klaus ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Colonic lavage; IBD; K ras; Molecular screening; P53

Indexed keywords

OLIGOMER; PROTEIN P53;

ARTICLE; COLON LAVAGE; COLORECTAL CANCER; CROHN DISEASE; ENTERITIS; FOLLOW UP; GENE MUTATION; GENETIC SCREENING; HIGH RISK POPULATION; HUMAN; HYBRIDIZATION; ONCOGENE K RAS; PREVALENCE; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; ULCERATIVE COLITIS;

ADULT; AGED; BIOPSY; CHRONIC DISEASE; COLITIS, ULCERATIVE; COLONOSCOPY; COLORECTAL NEOPLASMS; CROHN DISEASE; DNA MUTATIONAL ANALYSIS; FEMALE; FOLLOW-UP STUDIES; GENES, P53; GENES, RAS; GENETIC SCREENING; HUMANS; INFLAMMATORY BOWEL DISEASES; IRRIGATION; MALE; MIDDLE AGED; MUTATION; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 0036795921     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200210000-00005     Document Type: Article

References (26)

1. Eguchi S, Kohara N, Komuta K, Kanematsu T. Mutations of the p53 gene in the stool of patients with resectable colorectal cancer. Cancer 1996; 77(Suppl 1):1707-1710.
2. Potter MA, Morris RG, Ferguson A, Wyllie AH. Detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid. J Natl Cancer Inst 1998; 90:623-626.
3. Ronai Z. Ras oncogene detection in pre-neoplastic lesions: possible applications for diagnosis and prevention. Oncol Res 1992; 4:45-48.
4. Sidransky D, Tokino T, Hamilton SR, Kinzler KW, Levin B, Frost P, Vogelstein B. Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 1992; 256:102-105.
5. Smith-Ravin J, England J, Talbot IC, Bodmer W. Detection of c-Ki-ras mutations in faecal samples from sporadic colorectal cancer patients. Gut 1995; 36:81-86.
6. Tobi M, Luo FC, Ronai Z. Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma. J Natl Cancer Inst 1994; 86:1007-1010.
7. Lang SM, Heinzlmann M, Stratakis DF, Teschauer W, Loeschke K. Detection of Ki-ras mutations by PCR and differential hybridization and of p53 mutations by SSCP analysis in endoscopically obtained lavage solution from patients with long-standing ulcerative colitis. Am J Gastroenterol 1997; 92:2166-2170.
8. Lang SM, Stratakis DF, Heinzlmann M, Heldwein W, Wiebecke B, Loeschke K. Molecular screening of patients with long-standing extensive ulcerative colitis: detection of p53 and Ki-ras mutations by SSCP analysis and differential hybridization in colonic lavage fluid. Gut 1999; 44:822-825.
9. Villa E, Dugani A, Rebecchi AM, Vignoli A, Grottola A, Buttafoco P, et al. Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool. Gastroenterology 1996; 110:1346-1353.
10. Gillen CD, Walmsley RS, Prior P, Andrews HA, Allan RN. Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut 1994; 35:1590-1592.
11. Karlen P, Lofberg R, Brostrom O, Leijonmarck CE, Hellers G, Persson PG. Increased risk of cancer in ulcerative colitis: a population-based cohort study. Am J Gastroenterol 1999; 94:1047-1052.
12. Katzka I, Brody RS, Morris E, Katz S. Assessment of colorectal cancer risk in patients with ulcerative colitis: experience from a private practice. Gastroenterology 1983; 85:22-29.
13. Riddell RH, Goldman H, Ransohoff DF, Appelman HD, Fenoglio CM, Haggitt RC, et al. Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol 1983; 14:931-968.
14. Porschen R, Robin U, Schumacher A, Schauseil S, Borchard F, Hengels KJ, et al. DNA aneuploidy in Crohn's disease and ulcerative colitis: results of a comparative flow cytometric study. Gut 1992; 33:663-667.
15. Taylor HW, Boyle M, Smith SC, Bustin S, Williams NS. Expression of p53 in colorectal cancer and dysplasia complicating ulcerative colitis. Br J Surg 1993; 80:442-444.
16. Lennard-Jones JE, Melville DM, Morson BC, Ritchie JK, Williams CB. Precancer and cancer in extensive ulcerative colitis: findings among 401 patients over 22 years. Gut 1990; 31:800-806.
17. Riddell RH. How reliable/valid is dysplasia in identifying at-risk patients with ulcerative colitis? J Gastrointest Surg 1998; 2:314-317.
18. Ekbom A, Helmick C, Zack M, Adami HO. Ulcerative colitis and colorectal cancer. A population-based study. N Engl J Med 1990; 323:1228-1233.
19. Heuschen UA, Hinz U, Allemeyer EH, Stern J, Lucas M, Autschbach F, et al. Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis. Gastroenterology 2001; 120:841-847.
20. Gomes P, du Boulay C, Smith CL, Holdstock G. Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease. Gut 1986; 27:92-95.
21. Verlaan-de Vries M, Bogaard ME, Van der Elst H, Van Boom JH, Van der Eb AJ, Bos JL. A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides. Gene 1986; 50:313-320.
22. Teschauer W, Mussack T, Braun A, Waldner H, Fink E. Conditions for single strand conformation polymorphism (SSCP) analysis with broad applicability: a study on the effects of acrylamide, buffer and glycerol concentrations in SSCP analysis of exons of the p53 gene. Eur J Clin Chem Clin Biochem 1996; 34:125-131.
23. Murakami Y, Hayashi K, Sekiya T. Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis. Cancer Res 1991; 51:3356-3361.
24. Biasco G, Brandi G, Paganelli GM, Rossini FP, Santucci R, Di Febo G, et al. Colorectal cancer in patients with ulcerative colitis. A prospective cohort study in Italy. Cancer 1995; 75:2045-2050.
25. Holzmann K, Weis-Klemm M, Klump B, Hsieh CJ, Borchard F, Gregor M, Porschen R. Comparison of flow cytometry and histology with mutational screening for p53 and Ki-ras mutations in surveillance of patients with long-standing ulcerative colitis. Scand J Gastroenterol 2001; 36:1320-1326.
26. Hussain SP, Amstad P, Raja K, Ambs S, Nagashima M, Bennett WP, et al. Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res 2000; 60:3333-3337.