A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 2, 2008, Pages 822-829

  Smith, Emilie D ^a   Ariane Vinson, N ^a   Zhong, Desong ^a   Berrang, Bertold D ^a   Catanzaro, Jennifer L ^a   Thomas, James B ^a   Navarro, Hernán A ^a   Gilmour, Brian P ^a   Deschamps, Jeffrey ^b   Carroll, F Ivy ^a  

^a RTI INTERNATIONAL   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

Chiral synthesis; J 113397; NOP; ORL 1 antagonist

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; CALCIUM; COMPLEMENTARY DNA; DELTA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; OPIATE ANTAGONIST; OPIATE RECEPTOR; OPIOID LIKE RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM MOBILIZATION; CHIRALITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; X RAY ANALYSIS;

BENZIMIDAZOLES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, OPIOID; STEREOISOMERISM;

EID: 38549171441     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.023     Document Type: Article

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