A new approach to the synthesis of the nonpeptide NOP receptor antagonist J-113397

Synthesis

Volumn , Issue 10, 2007, Pages 1547-1553

  Sulima, Agnieszka ^a   Folk, John ^a   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

enaminoester reduction; Enantiomeric resolution; NOP antagonist; Receptor; Synthesis

Indexed keywords

ENAMINOESTER REDUCTION; ENANTIOMERIC RESOLUTION; NOP ANTAGONIST; RECEPTOR SYSTEM;

CHROMATOGRAPHIC ANALYSIS; ESTERS; ISOMERS; MAGNESIUM; METHANOL; REDUCTION; SEPARATION; SYNTHESIS (CHEMICAL);

PEPTIDES;

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; 1 BENZYL 4 (3 ETHYL 2 OXO 2,3 DIHYDROBENZOIMIDAZOL 1 YL) 1,2,5,6 TETRAHYDROPYRIDINE 3 CARBOXYLIC ACID METHYL ESTER; 4 OXOPIPERIDINECARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; MAGNESIUM; METHANOL; NOCICEPTIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; OPTICAL RESOLUTION; TRANS ISOMER;

EID: 34249793662     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-966037     Document Type: Article

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