-
1
-
-
1142287358
-
Clinical and epidemiologic burden of chronic myelogenous leukemia
-
REDAELLI A, BELL C, CASAGRANDE J et al. : Clinical and epidemiologic burden of chronic myelogenous leukemia. Expert Rev. Anticancer Ther. (2004) 4:85-96.
-
(2004)
Expert Rev. Anticancer Ther.
, vol.4
, pp. 85-96
-
-
Redaelli, A.1
Bell, C.2
Casagrande, J.3
-
3
-
-
33747154547
-
Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet
-
BACCARANI M, SAGLIO G, GOLDMAN J et al. : Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet. Blood (2006) 108:1809-1820.
-
(2006)
Blood
, vol.108
, pp. 1809-1820
-
-
Baccarani, M.1
Saglio, G.2
Goldman, J.3
-
5
-
-
79959308232
-
Loss of response to imatinib: Mechanisms and management
-
SHAH NP: Loss of response to imatinib: mechanisms and management. Hematol. Am. Soc. Hematol. Educ. Program (2005):183-187.
-
(2005)
Hematol. Am. Soc. Hematol. Educ. Program
, pp. 183-187
-
-
Shah, N.P.1
-
6
-
-
4344672552
-
Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
-
HOCHHAUS A, LA ROSÉE P: Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia (2004) 18:1321-1331.
-
(2004)
Leukemia
, vol.18
, pp. 1321-1331
-
-
Hochhaus, A.1
Roséep, L.A.2
-
7
-
-
33845344655
-
Mechanisms of resistance to imatinib in CML patients: A paradigm for the advantages and pitfalls of molecularly targeted therapy
-
RITCHIE E, NICHOLS G: Mechanisms of resistance to imatinib in CML patients: a paradigm for the advantages and pitfalls of molecularly targeted therapy. Curr. Cancer Drug Targets (2006) 6:645-657.
-
(2006)
Curr. Cancer Drug Targets
, vol.6
, pp. 645-657
-
-
Ritchie, E.1
Nichols, G.2
-
8
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'BRIEN SG, GUILHOT F, LARSON RA et al. : Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. (2003) 348:994-1004.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
9
-
-
33845444046
-
Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
-
DRUKER BJ, GUILHOT F, O'BRIEN SG et al. : Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. (2006) 355:2408-2417.
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 2408-2417
-
-
Druker, B.J.1
Guilhot, F.2
O'Brien, S.G.3
-
10
-
-
9144264829
-
Imatinib produces signifi cantly superior molecular responses compared to interferon α plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
-
BRANFORD S, RUDZKI Z, HARPER A et al. : Imatinib produces signifi cantly superior molecular responses compared to interferon α plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia (2003) 17:2401-2409.
-
(2003)
Leukemia
, vol.17
, pp. 2401-2409
-
-
Branford, S.1
Rudzki, Z.2
Harper, A.3
-
11
-
-
0037438467
-
Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
-
KANTARJIAN HM, TALPAZ M, O'BRIEN S et al. : Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood (2003) 101:473-475.
-
(2003)
Blood
, vol.101
, pp. 473-475
-
-
Kantarjian, H.M.1
Talpaz, M.2
O'Brien, S.3
-
12
-
-
80051754077
-
-
NOVARTIS PHARMA AG BS: Imatinib (Gleevec) prescribing information. Imatinib (Gleevec) prescribing information (2007)
-
NOVARTIS PHARMA AG BS: Imatinib (Gleevec) prescribing information. Imatinib (Gleevec) prescribing information (2007).
-
-
-
-
13
-
-
36348968931
-
Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
-
Epub ahead of print
-
KANTARJIAN HM, GILES F, GATTERMANN N et al.: Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood ( 2007 ):[Epub ahead of print].
-
(2007)
Blood
-
-
Kantarjian, H.M.1
Giles, F.2
Gattermann, N.3
-
14
-
-
37349061332
-
A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or-intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase
-
(Abstr. 0557)
-
LE COUTRE P, LARSON R, KANTARJIAN H et al. : A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or-intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase. Haematologica (2007) 92(Suppl. 1):207-208 (Abstr. 0557).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 1
, pp. 207-208
-
-
Coutre P, L.E.1
Larson, R.2
Kantarjian, H.3
-
15
-
-
37349112422
-
Nilotinib monotherapy in patients with imatinib-resistant or-intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/refractory Ph+ acute lymphoblastic leukemia
-
(Abstr. 0556)
-
OTTMANN O, LARSON R, KANTARJIAN H et al.: Nilotinib monotherapy in patients with imatinib-resistant or-intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/refractory Ph+ acute lymphoblastic leukemia. Haematologica (2007) 92(Suppl. 1):207 (Abstr. 0556).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 1
, pp. 207
-
-
Ottmann, O.1
Larson, R.2
Kantarjian, H.3
-
16
-
-
33846849302
-
New targeted therapies for chronic myelogenous leukemia: Opportunities to overcome imatinib resistance
-
JABBOUR E, CORTES J, O'BRIEN S, GILES F, KANTARJIAN H: New targeted therapies for chronic myelogenous leukemia: opportunities to overcome imatinib resistance. Semin. Hematol. (2007) 44:25-31.
-
(2007)
Semin. Hematol.
, vol.44
, pp. 25-31
-
-
Jabbour, E.1
Cortes, J.2
O'Brien, S.3
Giles, F.4
Kantarjian, H.5
-
17
-
-
29144492198
-
BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo
-
(Abstr. 675)
-
LEE FY, LOMBARDO L, CAMUSO A et al. : BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo. Proc. Am. Assoc. Cancer Res. (2005) 46:159 (Abstr. 675).
-
(2005)
Proc. Am. Assoc. Cancer Res.
, vol.46
, pp. 159
-
-
Lee, F.Y.1
Lombardo, L.2
Camuso, A.3
-
18
-
-
37349005461
-
Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib
-
FABARIUS A, GIEHL M, KRAEMER A, et al. : Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib. Blood (2006) 108:614a-615a.
-
(2006)
Blood
, vol.108
-
-
Fabarius, A.1
Giehl, M.2
Kraemer, A.3
-
19
-
-
33745243692
-
Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
-
SONG L, MORRIS M, BAGUIT et al.: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. (2006) 66:5542-5548.
-
(2006)
Cancer Res.
, vol.66
, pp. 5542-5548
-
-
Song, L.1
Baguit, M.M.2
-
20
-
-
21144451094
-
In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
-
O'HARE T, WALTERS DK, STOFFREGEN EP et al.: In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. (2005) 65:4500-4505.
-
(2005)
Cancer Res.
, vol.65
, pp. 4500-4505
-
-
O'Hare, T.1
Walters, D.K.2
Stoffregen, E.P.3
-
21
-
-
33745283618
-
The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
-
TOKARSKIJS, NEWITT JA, CHANG CY et al. : The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res. (2006) 66:5790-5797.
-
(2006)
Cancer Res
, vol.66
, pp. 5790-5797
-
-
Tokarskijs Newitt, J.A.1
Chang, C.Y.2
-
22
-
-
3142676436
-
Overriding imatinib resistance with a novel ABL kinase inhibitor
-
SHAH NP, TRAN C, LEE FY, CHEN P, NORRIS D, SAWYERS CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science (2004) 305:399-401.
-
(2004)
Science
, vol.305
, pp. 399-401
-
-
Shah, N.P.1
Tran, C.2
Lee, F.Y.3
Chen, P.4
Norris, D.5
Sawyers, C.L.6
-
23
-
-
80051757977
-
-
BRISTOL-MYERS SQUIBB prescribing information
-
BRISTOL-MYERS SQUIBB: Dasatinib (Sprycel) prescribing information (2007).
-
(2007)
Dasatinib (Sprycel)
-
-
-
24
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
TALPAZ M, SHAH NP, KANTARJIAN H et al. : Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. (2006) 354:2531-2541.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
-
25
-
-
33947280081
-
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
-
HOCHHAUS A, KANTARJIAN HM, BACCARANI M et al. : Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood (2007) 109:2303-2309.
-
(2007)
Blood
, vol.109
, pp. 2303-2309
-
-
Hochhaus, A.1
Kantarjian, H.M.2
Baccarani, M.3
-
26
-
-
37149036111
-
Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: Updated results of the CA180013 (START-C) trial
-
(Abstr. 0358)
-
GUILHOT F, APPERLEY J, FACON T et al. : Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: updated results of the CA180013 (START-C) trial. Haematologica (2007) 92(Suppl. 1): 128 (Abstr. 0358).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 1
, pp. 128
-
-
Guilhot, F.1
Apperley, J.2
Facon, T.3
-
27
-
-
34248324467
-
Dasatinib induces signifi cant hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase
-
GUILHOT F, APPERLEY J, KIM DW et al. : Dasatinib induces signifi cant hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase. Blood (2007) 109:4143-4150.
-
(2007)
Blood
, vol.109
, pp. 4143-4150
-
-
Guilhot, F.1
Apperley, J.2
Kim, D.W.3
-
28
-
-
34247543905
-
Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or-intolerant (im-i): Updated results of the CA180-005 START-A Phase II study
-
(Abstr. 2160)
-
CORTES J, KIM DW, GUILHOT F et al.: Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or-intolerant (im-i): updated results of the CA180-005 START-A Phase II study. Blood (2006) 108:613a (Abstr. 2160).
-
(2006)
Blood
, vol.108
-
-
Cortes, J.1
Kim, D.W.2
Guilhot, F.3
-
29
-
-
33947356135
-
Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in blast crisis
-
CORTES J, ROUSSELOT P, KIM DW et al. : Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in blast crisis. Blood (2007) 109:3207-3213.
-
(2007)
Blood
, vol.109
, pp. 3207-3213
-
-
Cortes, J.1
Rousselot, P.2
Kim, D.W.3
-
30
-
-
33846819360
-
Dasatinib (SPRYCEL) effi cacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or-intolerant (im-i)
-
(Abstr. 745)
-
MARTINELLI G, HOCHHAUS A, COUTRE S et al. : Dasatinib (SPRYCEL) effi cacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or-intolerant (im-i). Blood (2006) 108:224a (Abstr. 745).
-
(2006)
Blood
, vol.108
-
-
Martinelli, G.1
Hochhaus, A.2
Coutre, S.3
-
31
-
-
34249074686
-
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized Phase II trial
-
KANTARJIAN H, PASQUINI R, HAMERSCHLAK N et al. : Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized Phase II trial. Blood (2007) 109:5143-5150.
-
(2007)
Blood
, vol.109
, pp. 5143-5150
-
-
Kantarjian, H.1
Pasquini, R.2
Hamerschlak, N.3
-
32
-
-
37349126943
-
Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase
-
(Abstr. 0360)
-
QUINTAS-CARDAMA A, KANTARJIAN H, O'BRIEN S et al.: Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase. Haematologica (2007) 92(Suppl. 1):129 (Abstr. 0360).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 1
, pp. 129
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
O'Brien, S.3
-
33
-
-
37149031172
-
Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: Results from a randomized Phase-III trial (CA180034)
-
(Abstr. 0359)
-
HOCHHAUS A, KIM DW, ROUSSELOT P et al. : Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: results from a randomized Phase-III trial (CA180034). Haematologica (2007) 92(Suppl.1):128-129 (Abstr. 0359).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL.1
, pp. 128-129
-
-
Hochhaus, A.1
Kim, D.W.2
Rousselot, P.3
-
34
-
-
37349115522
-
Dasatinib 140 mg QD vs 70 mg b.i.d. in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: Results from a randomized Phase-III trial (CA180035)
-
(Abstr. 0859)
-
DOMBRET H, OTTMANN OG, GOH Y et al. : Dasatinib 140 mg QD vs 70 mg b.i.d. in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: results from a randomized, Phase-III trial (CA180035). Haematologica (2007) 92 (Suppl.1):319 (Abstr. 0859).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL.1
, pp. 319
-
-
Dombret, H.1
Ottmann, O.G.2
Goh, Y.3
-
35
-
-
35349001079
-
Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: A case series
-
BERGERON A, RÉA D, LEVY V et al.: Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am. J. Respir. Crit. Care Med. (2007) 176:814-818.
-
(2007)
Am. J. Respir. Crit. Care Med.
, vol.176
, pp. 814-818
-
-
Bergeron, A.1
Réa, D.2
Levy, V.3
-
36
-
-
20944442975
-
Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
-
CORTES J, TALPAZ M, O'BRIEN S et al. : Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin. Cancer Res. (2005) 11:3425-3432.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 3425-3432
-
-
Cortes, J.1
Talpaz, M.2
O'Brien, S.3
-
37
-
-
0348015863
-
The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
-
WANG L, PEARSON K, FERGUSON JE, CLARK RE: The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br. J. Haematol. (2003) 120:990-999.
-
(2003)
Br. J. Haematol.
, vol.120
, pp. 990-999
-
-
Wang, L.1
Pearson, K.2
Ferguson, J.E.3
Clark, R.E.4
-
38
-
-
33744486584
-
Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
-
COPLAND M, HAMILTON A, ELRICK LJ et al.: Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood (2006) 107:4532-4539.
-
(2006)
Blood
, vol.107
, pp. 4532-4539
-
-
Copland, M.1
Hamilton, A.2
Elrick, L.J.3
-
39
-
-
37349092298
-
Effi cacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations
-
(Abstr. 0356)
-
MÜLLER MC, BRANFORD S, RADICH J et al.: Effi cacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations. Haematologica (2007) 92(Suppl. 1):127 (Abstr. 0356).
-
(2007)
Haematologica
, vol.92
, Issue.SUPPL. 1
, pp. 127
-
-
Müller, M.C.1
Branford, S.2
Radich, J.3
|