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Volumn 8, Issue 18, 2007, Pages 3257-3264

Dasatinib for the treatment of Philadelphia chromosome-positive chronic myelogenous leukaemia after imatinib failure

Author keywords

BCR ABL; chronic myelogenous leukemia; dasatinib; imatinib; Philadelphia chromosome

Indexed keywords

ANTINEOPLASTIC AGENT; DASATINIB; IMATINIB; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; THIAZOLE DERIVATIVE;

EID: 38549167019     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.8.18.3257     Document Type: Article
Times cited : (21)

References (40)
  • 1
    • 1142287358 scopus 로고    scopus 로고
    • Clinical and epidemiologic burden of chronic myelogenous leukemia
    • REDAELLI A, BELL C, CASAGRANDE J et al. : Clinical and epidemiologic burden of chronic myelogenous leukemia. Expert Rev. Anticancer Ther. (2004) 4:85-96.
    • (2004) Expert Rev. Anticancer Ther. , vol.4 , pp. 85-96
    • Redaelli, A.1    Bell, C.2    Casagrande, J.3
  • 3
    • 33747154547 scopus 로고    scopus 로고
    • Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet
    • BACCARANI M, SAGLIO G, GOLDMAN J et al. : Evolving concepts in the management of chronic myeloid leukemia. Recommendations from an expert panel on behalf of the European Leukemianet. Blood (2006) 108:1809-1820.
    • (2006) Blood , vol.108 , pp. 1809-1820
    • Baccarani, M.1    Saglio, G.2    Goldman, J.3
  • 4
    • 33846847772 scopus 로고    scopus 로고
    • Resistance to targeted therapy in chronic myelogenous leukemia
    • HOCHHAUS A, ERBEN P, ERNST T, MUELLER MC: Resistance to targeted therapy in chronic myelogenous leukemia. Semin. Hematol. (2007) 44:15-24.
    • (2007) Semin. Hematol. , vol.44 , pp. 15-24
    • Hochhaus, A.1    Erben, P.2    Ernst, T.3    Mueller, M.C.4
  • 5
    • 79959308232 scopus 로고    scopus 로고
    • Loss of response to imatinib: Mechanisms and management
    • SHAH NP: Loss of response to imatinib: mechanisms and management. Hematol. Am. Soc. Hematol. Educ. Program (2005):183-187.
    • (2005) Hematol. Am. Soc. Hematol. Educ. Program , pp. 183-187
    • Shah, N.P.1
  • 6
    • 4344672552 scopus 로고    scopus 로고
    • Imatinib therapy in chronic myelogenous leukemia: Strategies to avoid and overcome resistance
    • HOCHHAUS A, LA ROSÉE P: Imatinib therapy in chronic myelogenous leukemia: strategies to avoid and overcome resistance. Leukemia (2004) 18:1321-1331.
    • (2004) Leukemia , vol.18 , pp. 1321-1331
    • Hochhaus, A.1    Roséep, L.A.2
  • 7
    • 33845344655 scopus 로고    scopus 로고
    • Mechanisms of resistance to imatinib in CML patients: A paradigm for the advantages and pitfalls of molecularly targeted therapy
    • RITCHIE E, NICHOLS G: Mechanisms of resistance to imatinib in CML patients: a paradigm for the advantages and pitfalls of molecularly targeted therapy. Curr. Cancer Drug Targets (2006) 6:645-657.
    • (2006) Curr. Cancer Drug Targets , vol.6 , pp. 645-657
    • Ritchie, E.1    Nichols, G.2
  • 8
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'BRIEN SG, GUILHOT F, LARSON RA et al. : Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. (2003) 348:994-1004.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 9
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • DRUKER BJ, GUILHOT F, O'BRIEN SG et al. : Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. (2006) 355:2408-2417.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3
  • 10
    • 9144264829 scopus 로고    scopus 로고
    • Imatinib produces signifi cantly superior molecular responses compared to interferon α plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase
    • BRANFORD S, RUDZKI Z, HARPER A et al. : Imatinib produces signifi cantly superior molecular responses compared to interferon α plus cytarabine in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Leukemia (2003) 17:2401-2409.
    • (2003) Leukemia , vol.17 , pp. 2401-2409
    • Branford, S.1    Rudzki, Z.2    Harper, A.3
  • 11
    • 0037438467 scopus 로고    scopus 로고
    • Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia
    • KANTARJIAN HM, TALPAZ M, O'BRIEN S et al. : Dose escalation of imatinib mesylate can overcome resistance to standard-dose therapy in patients with chronic myelogenous leukemia. Blood (2003) 101:473-475.
    • (2003) Blood , vol.101 , pp. 473-475
    • Kantarjian, H.M.1    Talpaz, M.2    O'Brien, S.3
  • 12
    • 80051754077 scopus 로고    scopus 로고
    • NOVARTIS PHARMA AG BS: Imatinib (Gleevec) prescribing information. Imatinib (Gleevec) prescribing information (2007)
    • NOVARTIS PHARMA AG BS: Imatinib (Gleevec) prescribing information. Imatinib (Gleevec) prescribing information (2007).
  • 13
    • 36348968931 scopus 로고    scopus 로고
    • Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance
    • Epub ahead of print
    • KANTARJIAN HM, GILES F, GATTERMANN N et al.: Nilotinib (formerly AMN107), a highly selective Bcr-Abl tyrosine kinase inhibitor, is effective in patients with Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase following imatinib resistance and intolerance. Blood ( 2007 ):[Epub ahead of print].
    • (2007) Blood
    • Kantarjian, H.M.1    Giles, F.2    Gattermann, N.3
  • 14
    • 37349061332 scopus 로고    scopus 로고
    • A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or-intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase
    • (Abstr. 0557)
    • LE COUTRE P, LARSON R, KANTARJIAN H et al. : A Phase II study of nilotinib, a novel tyrosine kinase inhibitor administered to imatinib-resistant or-intolerant patients with Philadelphia-positive chronic myelogenous leukemia in accelerated phase. Haematologica (2007) 92(Suppl. 1):207-208 (Abstr. 0557).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 207-208
    • Coutre P, L.E.1    Larson, R.2    Kantarjian, H.3
  • 15
    • 37349112422 scopus 로고    scopus 로고
    • Nilotinib monotherapy in patients with imatinib-resistant or-intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/refractory Ph+ acute lymphoblastic leukemia
    • (Abstr. 0556)
    • OTTMANN O, LARSON R, KANTARJIAN H et al.: Nilotinib monotherapy in patients with imatinib-resistant or-intolerant Ph+ chronic myelogenous leukemia in blast crisis or relapsed/refractory Ph+ acute lymphoblastic leukemia. Haematologica (2007) 92(Suppl. 1):207 (Abstr. 0556).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 207
    • Ottmann, O.1    Larson, R.2    Kantarjian, H.3
  • 16
    • 33846849302 scopus 로고    scopus 로고
    • New targeted therapies for chronic myelogenous leukemia: Opportunities to overcome imatinib resistance
    • JABBOUR E, CORTES J, O'BRIEN S, GILES F, KANTARJIAN H: New targeted therapies for chronic myelogenous leukemia: opportunities to overcome imatinib resistance. Semin. Hematol. (2007) 44:25-31.
    • (2007) Semin. Hematol. , vol.44 , pp. 25-31
    • Jabbour, E.1    Cortes, J.2    O'Brien, S.3    Giles, F.4    Kantarjian, H.5
  • 17
    • 29144492198 scopus 로고    scopus 로고
    • BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo
    • (Abstr. 675)
    • LEE FY, LOMBARDO L, CAMUSO A et al. : BMS-354825 potently inhibits multiple selected oncogenic tyrosine kinases and possesses broad-spectrum antitumor activities in vitro and in vivo. Proc. Am. Assoc. Cancer Res. (2005) 46:159 (Abstr. 675).
    • (2005) Proc. Am. Assoc. Cancer Res. , vol.46 , pp. 159
    • Lee, F.Y.1    Lombardo, L.2    Camuso, A.3
  • 18
    • 37349005461 scopus 로고    scopus 로고
    • Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib
    • FABARIUS A, GIEHL M, KRAEMER A, et al. : Centrosome aberrations, disturbed mitotic spindle formation and G1 arrest in normal and leukemic cells treated with the SRC/ABL inhibitor dasatinib. Blood (2006) 108:614a-615a.
    • (2006) Blood , vol.108
    • Fabarius, A.1    Giehl, M.2    Kraemer, A.3
  • 19
    • 33745243692 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival
    • SONG L, MORRIS M, BAGUIT et al.: Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. (2006) 66:5542-5548.
    • (2006) Cancer Res. , vol.66 , pp. 5542-5548
    • Song, L.1    Baguit, M.M.2
  • 20
    • 21144451094 scopus 로고    scopus 로고
    • In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants
    • O'HARE T, WALTERS DK, STOFFREGEN EP et al.: In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants. Cancer Res. (2005) 65:4500-4505.
    • (2005) Cancer Res. , vol.65 , pp. 4500-4505
    • O'Hare, T.1    Walters, D.K.2    Stoffregen, E.P.3
  • 21
    • 33745283618 scopus 로고    scopus 로고
    • The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants
    • TOKARSKIJS, NEWITT JA, CHANG CY et al. : The structure of dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants. Cancer Res. (2006) 66:5790-5797.
    • (2006) Cancer Res , vol.66 , pp. 5790-5797
    • Tokarskijs Newitt, J.A.1    Chang, C.Y.2
  • 22
    • 3142676436 scopus 로고    scopus 로고
    • Overriding imatinib resistance with a novel ABL kinase inhibitor
    • SHAH NP, TRAN C, LEE FY, CHEN P, NORRIS D, SAWYERS CL: Overriding imatinib resistance with a novel ABL kinase inhibitor. Science (2004) 305:399-401.
    • (2004) Science , vol.305 , pp. 399-401
    • Shah, N.P.1    Tran, C.2    Lee, F.Y.3    Chen, P.4    Norris, D.5    Sawyers, C.L.6
  • 23
    • 80051757977 scopus 로고    scopus 로고
    • BRISTOL-MYERS SQUIBB prescribing information
    • BRISTOL-MYERS SQUIBB: Dasatinib (Sprycel) prescribing information (2007).
    • (2007) Dasatinib (Sprycel)
  • 24
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • TALPAZ M, SHAH NP, KANTARJIAN H et al. : Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. (2006) 354:2531-2541.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 25
    • 33947280081 scopus 로고    scopus 로고
    • Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
    • HOCHHAUS A, KANTARJIAN HM, BACCARANI M et al. : Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy. Blood (2007) 109:2303-2309.
    • (2007) Blood , vol.109 , pp. 2303-2309
    • Hochhaus, A.1    Kantarjian, H.M.2    Baccarani, M.3
  • 26
    • 37149036111 scopus 로고    scopus 로고
    • Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: Updated results of the CA180013 (START-C) trial
    • (Abstr. 0358)
    • GUILHOT F, APPERLEY J, FACON T et al. : Dasatinib induces durable cytogenetic responses in patients with chronic-phase CML with resistance or intolerance to imatinib: updated results of the CA180013 (START-C) trial. Haematologica (2007) 92(Suppl. 1): 128 (Abstr. 0358).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 128
    • Guilhot, F.1    Apperley, J.2    Facon, T.3
  • 27
    • 34248324467 scopus 로고    scopus 로고
    • Dasatinib induces signifi cant hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase
    • GUILHOT F, APPERLEY J, KIM DW et al. : Dasatinib induces signifi cant hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in accelerated phase. Blood (2007) 109:4143-4150.
    • (2007) Blood , vol.109 , pp. 4143-4150
    • Guilhot, F.1    Apperley, J.2    Kim, D.W.3
  • 28
    • 34247543905 scopus 로고    scopus 로고
    • Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or-intolerant (im-i): Updated results of the CA180-005 START-A Phase II study
    • (Abstr. 2160)
    • CORTES J, KIM DW, GUILHOT F et al.: Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in accelerated phase (AP-CML) that is imatinib-resistant (im-r) or-intolerant (im-i): updated results of the CA180-005 START-A Phase II study. Blood (2006) 108:613a (Abstr. 2160).
    • (2006) Blood , vol.108
    • Cortes, J.1    Kim, D.W.2    Guilhot, F.3
  • 29
    • 33947356135 scopus 로고    scopus 로고
    • Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in blast crisis
    • CORTES J, ROUSSELOT P, KIM DW et al. : Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or-intolerant chronic myeloid leukemia in blast crisis. Blood (2007) 109:3207-3213.
    • (2007) Blood , vol.109 , pp. 3207-3213
    • Cortes, J.1    Rousselot, P.2    Kim, D.W.3
  • 30
    • 33846819360 scopus 로고    scopus 로고
    • Dasatinib (SPRYCEL) effi cacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or-intolerant (im-i)
    • (Abstr. 745)
    • MARTINELLI G, HOCHHAUS A, COUTRE S et al. : Dasatinib (SPRYCEL) effi cacy and safety in patients (pts) with chronic myelogenous leukemia in lymphoid (CML-LB) or myeloid blast (CML-MB) phase who are imatinib-resistant (im-r) or-intolerant (im-i). Blood (2006) 108:224a (Abstr. 745).
    • (2006) Blood , vol.108
    • Martinelli, G.1    Hochhaus, A.2    Coutre, S.3
  • 31
    • 34249074686 scopus 로고    scopus 로고
    • Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: A randomized Phase II trial
    • KANTARJIAN H, PASQUINI R, HAMERSCHLAK N et al. : Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized Phase II trial. Blood (2007) 109:5143-5150.
    • (2007) Blood , vol.109 , pp. 5143-5150
    • Kantarjian, H.1    Pasquini, R.2    Hamerschlak, N.3
  • 32
    • 37349126943 scopus 로고    scopus 로고
    • Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase
    • (Abstr. 0360)
    • QUINTAS-CARDAMA A, KANTARJIAN H, O'BRIEN S et al.: Dasatinib is safe and effective in patients with previously untreated chronic myelogenous leukemia in chronic phase. Haematologica (2007) 92(Suppl. 1):129 (Abstr. 0360).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 129
    • Quintas-Cardama, A.1    Kantarjian, H.2    O'Brien, S.3
  • 33
    • 37149031172 scopus 로고    scopus 로고
    • Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: Results from a randomized Phase-III trial (CA180034)
    • (Abstr. 0359)
    • HOCHHAUS A, KIM DW, ROUSSELOT P et al. : Dasatinib dose and schedule optimization in chronic-phase CML resistant or intolerant to imatinib: results from a randomized Phase-III trial (CA180034). Haematologica (2007) 92(Suppl.1):128-129 (Abstr. 0359).
    • (2007) Haematologica , vol.92 , Issue.SUPPL.1 , pp. 128-129
    • Hochhaus, A.1    Kim, D.W.2    Rousselot, P.3
  • 34
    • 37349115522 scopus 로고    scopus 로고
    • Dasatinib 140 mg QD vs 70 mg b.i.d. in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: Results from a randomized Phase-III trial (CA180035)
    • (Abstr. 0859)
    • DOMBRET H, OTTMANN OG, GOH Y et al. : Dasatinib 140 mg QD vs 70 mg b.i.d. in advanced-phase CML or Ph(+) ALL resistant or intolerant to imatinib: results from a randomized, Phase-III trial (CA180035). Haematologica (2007) 92 (Suppl.1):319 (Abstr. 0859).
    • (2007) Haematologica , vol.92 , Issue.SUPPL.1 , pp. 319
    • Dombret, H.1    Ottmann, O.G.2    Goh, Y.3
  • 35
    • 35349001079 scopus 로고    scopus 로고
    • Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: A case series
    • BERGERON A, RÉA D, LEVY V et al.: Lung abnormalities after dasatinib treatment for chronic myeloid leukemia: a case series. Am. J. Respir. Crit. Care Med. (2007) 176:814-818.
    • (2007) Am. J. Respir. Crit. Care Med. , vol.176 , pp. 814-818
    • Bergeron, A.1    Réa, D.2    Levy, V.3
  • 36
    • 20944442975 scopus 로고    scopus 로고
    • Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate
    • CORTES J, TALPAZ M, O'BRIEN S et al. : Molecular responses in patients with chronic myelogenous leukemia in chronic phase treated with imatinib mesylate. Clin. Cancer Res. (2005) 11:3425-3432.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 3425-3432
    • Cortes, J.1    Talpaz, M.2    O'Brien, S.3
  • 37
    • 0348015863 scopus 로고    scopus 로고
    • The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia
    • WANG L, PEARSON K, FERGUSON JE, CLARK RE: The early molecular response to imatinib predicts cytogenetic and clinical outcome in chronic myeloid leukaemia. Br. J. Haematol. (2003) 120:990-999.
    • (2003) Br. J. Haematol. , vol.120 , pp. 990-999
    • Wang, L.1    Pearson, K.2    Ferguson, J.E.3    Clark, R.E.4
  • 38
    • 33744486584 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction
    • COPLAND M, HAMILTON A, ELRICK LJ et al.: Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood (2006) 107:4532-4539.
    • (2006) Blood , vol.107 , pp. 4532-4539
    • Copland, M.1    Hamilton, A.2    Elrick, L.J.3
  • 39
    • 37349092298 scopus 로고    scopus 로고
    • Effi cacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations
    • (Abstr. 0356)
    • MÜLLER MC, BRANFORD S, RADICH J et al.: Effi cacy of dasatinib in chronic phase chronic myelogenous leukemia patients after imatinib failure according to baseline BCR-ABL mutations. Haematologica (2007) 92(Suppl. 1):127 (Abstr. 0356).
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 1 , pp. 127
    • Müller, M.C.1    Branford, S.2    Radich, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.