Non-hydrolytic functions of acetylcholinesterase: The significance of C-terminal peptides

FEBS Journal

Volumn 275, Issue 4, 2008, Pages 604-611

  Greenfield, Susan A ^a   Zimmermann, Martina ^a,b   Bond, Cherie E ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Alzheimer's; Degeneration; Development; Global neurons; Motor neuron disease; Nicotinic receptor; Oxidative stress; Parkinson's; Substrate inhibition; Trophic toxic axis

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID PROTEIN; BUNGAROTOXIN RECEPTOR; CALCIUM CHANNEL L TYPE; CARBOXY TERMINAL TELOPEPTIDE;

ALZHEIMER DISEASE; BRAIN REGION; DEGENERATIVE DISEASE; HUMAN; MOTOR NEURON DISEASE; NERVE CELL PLASTICITY; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; PROTEIN INTERACTION; SHORT SURVEY;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; HUMANS; MODELS, BIOLOGICAL; MOTOR NEURON DISEASE; NERVE DEGENERATION; PARKINSON DISEASE; PEPTIDES; SIGNAL TRANSDUCTION;

EID: 38549159882     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.06235.x     Document Type: Short Survey

References (46)

1. Dally JJ Greenfield SA (1994) The release of acetylcholinesterase in vivo is regulated by dopaminergic systems in the guinea-pig substantia nigra. Neurochem Int 25, 339 344.
2. Greenfield SA Shaw SG (1982) Release of acetylcholinesterase and aminopeptidase in vivo following infusion of amphetamine into the substantia nigra. Neuroscience 7, 2883 2893.
3. Woolf NJ (1996) Global and serial neurons form a hierarchically arranged interface proposed to underlie memory and cognition. Neuroscience 74, 625 651.
4. Day T Greenfield SA (2002) A non-cholinergic, trophic action of acetylcholinesterase on hippocampal neurones in vitro: molecular mechanisms. Neuroscience 111, 649 656.
5. Day T Greenfield SA (2003) A peptide derived from acetylcholinesterase induces neuronal cell death: characterisation of possible mechanisms. Exp Brain Res 153, 334 342.
6. Taylor SJ, Bartlett MJ Greenfield SA (1988) Release of acetylcholinesterase within the guinea-pig substantia nigra: effects of 5-hydroxytryptamine and amphetamine. Neuropharmacology 27, 507 514.
7. Webb CP, Nedergaard S, Giles K Greenfield SA (1996) Involvement of the NMDA receptor in a non-cholinergic action of acetylcholinesterase in guinea-pig substantia nigra pars compacta neurons. Eur J Neurosci 8, 837 841.
8. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells. J Neurosci 14, 187 197.
9. 2+ influx through glutamate receptor-associated channels in retina cells correlates with neuronal cell death. Eur J Pharmacol 302, 153 162.
10. Van Reempts J Borgers M (1985) Ischemic brain injury and cell calcium: morphologic and therapeutic aspects. Ann Emerg Med 14, 736 742.
11. Eimerl S Schramm M (1994) The quantity of calcium that appears to induce neuronal death. J Neurochem 62, 1223 1226.
12. Schmitt HP (2005) Neuro-modulation, aminergic neuro-disinhibition and neuro-degeneration. Draft of a comprehensive theory for Alzheimer disease. Med Hyp 65, 1106 1119.
13. Rossor MN (1981) Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core. Br Med J (Clin Res Ed) 283, 1588 1590.
14. Greenfield S Vaux DJ (2002) Parkinson's disease, Alzheimer's disease and motor neurone disease: identifying a common mechanism. Neuroscience 113, 485 492.
15. Bon CL Greenfield SA (2003) Bioactivity of a peptide derived from acetylcholinesterase: electrophysiological characterization in guinea-pig hippocampus. Eur J Neurosci 17, 1991 1995.
16. Bond CE Greenfield SA (2007) Multiple cascade effects of oxidative stress on astroglia. Glia 55, 1348 1361.
17. Patrick J, Sequela P, Vernino S, Amador M, Luetje C Dani JA (1993) Functional diversity of neuronal nicotinic acetylcholine receptors. Prog Brain Res 98, 113 120.
18. Broide RS, Robertson RT Leslie FM (1996) Regulation of alpha 7 nicotinic acetylcholine receptors in the developing rat somatosensory cortex by thalamocortical afferents. J Neurosci 16, 2956 2971.
19. Dineley KT (2007) Beta-amyloid peptide-nicotinic acetylcholine receptor interaction: the two faces of health and disease. Front Biosci 12, 5030 5038.
20. Dineley KT, Bell KA, Bui D Sweatt JD (2002) Beta-amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem 277, 25056 25061.
21. Lain E, Penke B, Delacourte A, Gundisch D, Schroder H Witter B (2005) Effects of Abeta1-42 fibrils and of the tetrapeptide Pr-IIGL on the phosphorylation state of the tau-protein and on the alpha7 nicotinic acetylcholine receptor in vitro. Eur J Neurosci 21, 879 888.
22. Gotti C, Moretti M, Bohr I, Ziabreva I, Vailati S, Longhi R, Riganti L, Gaimarri A, McKeith IG, Perry RH et al. (2006) Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation. Neurobiol Dis 23, 481 489.
23. Wang HY, Lee DH, Davis CB Shank RP (2000) Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors. J Neurochem 75, 1155 1161.
24. Fodero LR, Mok SS, Losic D, Martin LL, Aguilar MI, Barrow CJ, Livett BG Small DH (2004) Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones. J Neurochem 88, 1186 1193.
25. Dineley KT, Westerman M, Bui D, Bell K, Ashe KH Sweatt JD (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci 21, 4125 4133.
26. Duda JE (2004) Pathology and neurotransmitter abnormalities of dementia with Lewy bodies. Dement Geriatr Cogn Disord 17 (Suppl. 1 3 14.
27. Nagele RG, D'Andrea MR, Anderson WJ Wang HY (2002) Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease. Neuroscience 110, 199 211.
28. Greenfield SA, Day T, Mann EO Bermudez I (2004) A novel peptide modulates alpha7 nicotinic receptor responses: implications for a possible trophic-toxic mechanism within the brain. J Neurochem 90, 325 331.
29. Cottingham MG, Hollinshead MS Vaux DJ (2002) Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide. Biochemistry 41, 13539 13547.
30. Cottingham MG, Voskuil JL Vaux DJ (2003) The intact human acetylcholinesterase C-terminal oligomerization domain is alpha-helical in situ and in isolation, but a shorter fragment forms beta-sheet-rich amyloid fibrils and protofibrillar oligomers. Biochemistry 42, 10863 10873.
31. Small DH, Michaelson S Sberna G (1996) Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochem Int 28, 453 483.
32. Onganer PU, Djamgoz MB, Whyte K Greenfield SA (2006) An acetylcholinesterase-derived peptide inhibits endocytic membrane activity in a human metastatic breast cancer cell line. Biochim Biophys Acta 1760, 415 420.
33. Bond CE, Patel P, Crouch L, Tetlow N, Day T, Abu-Hayyeh S, Williamson C Greenfield SA (2006) Astroglia up-regulate transcription and secretion of 'readthrough' acetylcholinesterase following oxidative stress. Eur J Neurosci 24, 381 386.
34. Deutsch VR, Pick M, Perry C, Grisaru D, Hemo Y, Golan-Hadari D, Grant A, Eldor A Soreq H (2002) The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation. Exp Hematol 30, 1153 1161.
35. Nijholt I, Farchi N, Kye M, Sklan EH, Shoham S, Verbeure B, Owen D, Hochner B, Spiess J, Soreq H et al. (2004) Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation. Mol Psychiatry 9, 174 183.
36. Teaktong T, Graham A, Court J, Perry R, Jaros E, Johnson M, Hall R Perry E (2003) Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytes. Glia 41, 207 211.
37. Song H, Stevens CF Gage FH (2002) Astroglia induce neurogenesis from adult neural stem cells. Nature 417, 39 44.
38. Coleman BA Taylor P (1996) Regulation of acetylcholinesterase expression during neuronal differentiation. J Biol Chem 271, 4410 4416.
39. Marchetti B, Kettenmann H Streit WJ (2005) Glia-neuron crosstalk in neuroinflammation, neurodegeneration and neuroprotection - introduction. Brain Res Rev 48, 129 132.
40. Kempermann G Gage FH (1999) Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. Hippocampus 9, 321 332.
41. Kempermann G, Gast D Gage FH (2002) Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann Neurol 52, 135 143.
42. Saxena A, Hur RS, Luo C Doctor BP (2003) Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain. Biochemistry 42, 15292 15299.
43. Moreno RD, Campos FO, Dajas F Inestrosa NC (1998) Developmental regulation of mouse brain monomeric acetylcholinesterase. Int J Dev Neurosci 16, 123 134.
44. Arendt T, Bruckner MK, Lange M Bigl V (1992) Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development - a study of molecular forms. Neurochem In 21, 381 396.
45. Zimmermann M, Groesgen S, Westwell MS Greenfield SA (2007) Selective enhancement of the activity of C-terminally truncated, but not intact, acetylcholinesterase. J Neurochem 104, 221 232.
46. Bourne Y, Taylor P, Bougis PE Marchot P (1999) Crystal structure of mouse acetylcholinesterase, a peripheral site-occluding loop in a tetrameric assembly. J Biol Che 274, 2963 2970.