Parkinson's disease, Alzheimer's disease and motor neurone disease: Identifying a common mechanism

Neuroscience

Volumn 113, Issue 3, 2002, Pages 485-492

  Greenfield, S ^a   Vaux, D J ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Acetylcholinesterase; Amyloid precursor protein; Brainstem nuclei; Neurodegeneration; Peptide

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; CARBOXY TERMINAL SEQUENCE; DEGENERATIVE DISEASE; DISEASE COURSE; HUMAN; MOTOR NEURON DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN MOTIF; REVIEW; SEQUENCE HOMOLOGY; AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL DEATH; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL DEATH; HUMANS; MOLECULAR SEQUENCE DATA; MOTOR NEURON DISEASE; PARKINSON DISEASE;

EID: 0037008862     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(02)00194-X     Document Type: Article

References (65)

1. Frequency of dementia in Parkinson disease
2. Absence of central cholinergic deficits in ApoE knockout mice
3. Transgenic acetylcholinesterase induces enlargement of murine neuromuscular junctions but leaves spinal cord synapses intact
4. Acetylcholinesterase induces long-term potentiation in CA1 pyramidal cells by a mechanism dependent on metabotropic glutamate receptors
5. Reduced adrenal gland acetylcholinesterase activity in Alzheimer's disease
6. Secretion of acetylcholinesterase and butyrylcholinesterase from the guinea-pig isolated ileum
7. Release of acetylcholinesterase from the guinea-pig cerebellum in vivo
8. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organisation
9. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development - a study of molecular forms
10. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons
11. Influence of acetylcholinesterase on embryonic spinal rat motoneurones growth in culture: A quantitative morphometric study
12. Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice
13. A confocal microscopic analysis of galaninergic hyperinnervation of cholinergic basal forebrain neurons in Alzheimer's disease
14. Molecular forms of acetylcholinesterase in brain, nerve and muscle: Nature, localization and dynamics
15. Amyloid precursor protein fragment and acetylcholinesterase increase with cell confluence and differentiation in a neuronal cell line
16. Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain
17. Toxic effects of acetylcholinesterase on neuronal and glial-like cells in vitro
18. Alzheimer's disease, Parkinson's disease, and motorneurone disease: Abiotropic interaction between ageing and environment?
19. Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice
20. Release of acetylcholinesterase into the perfusate from the ox adrenal gland
21. Pharmacological and functional properties of voltage-independent Ca2+ channels
22. Regulation of acetylcholinesterase expression during neuronal differentiation
23. Selective vulnerability of alpha motor neurons in ALS: Relation to autoantibodies toward acetylcholinesterase (AChE) in ALS patients
24. A non-cholinergic, trophic action of acetylcholinesterase on hippocampal neurons in vitro: Molecular mechanisms
25. A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein
26. Epidemiology and pathophysiology of Alzheimer's disease
27. Neurotoxic and neurotrophic effects of chronic N-methyl-D-aspartate exposure upon mesencephalic dopaminergic neurons in organotypic culture
28. The quantity of calcium that appears to induce neuronal death
29. Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease
30. Trophic-factor modulation of cortical acetylcholinesterase reappearance following transection of the medial cholinergic pathway in the adult rat
31. Overexpressions of cDNAs for beta-amyloid precursor proteins 695, 751, and 770 enhance the secretion of beta-amyloid precursor protein derivatives and the survival of P19-derived neurons
32. Alzheimer's disease with and without coexisting Parkinson's disease changes: Apolipoprotein E genotype and neuropathologic correlates
33. Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease
34. In vivo release of acetylcholinesterase in cat substantia nigra and caudate nucleus
35. Responses of basal forebrain cholinergic neurons to damage in the adult brain
36. Non-cholinergic, trophic action of recombinant acetylcholinesterase on mid-brain dopaminergic neurons
37. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IX. A prospective cliniconeuropathologic study of Parkinson's features in Alzheimer's disease
38. Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: Possible role of the peripheral site of the enzyme
39. The effect of acetylcholinesterase on outgrowth of dopaminergic neurons in organotypic slice culture of rat mid-brain
40. Overexpression of alternative human acetylcholinesterase forms modulates process extensions in cultured glioma cells
41. Acetylcholinesterase activation of peritoneal macrophages is independent of catalytic activity
42. Activation of macrophages by Alzheimer beta-amyloid peptide
43. Sustained inhibition of acetylcholinesterase activity does not disrupt early geniculocortical ingrowth to developing rat visual cortex
44. Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis
45. Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors
46. The cell division cycle and the pathophysiology of Alzheimer's disease
47. Anomalous molecular form of acetylcholinesterase in cerebrospinal fluid in histologically diagnosed Alzheimer's disease
48. Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice
49. Acetylcholinesterase and neural development - new tricks for an old dog
50. Motor neurone acetylcholinesterase release precedes neurotoxicity caused by systemic administration of excitatory amino acids and strychnine
51. Release of acetylcholinesterase from superfused slices of rat hypothalamus
52. Parkinson's disease and Alzheimer's disease as disorders of the isodendritic core
53. Immunoglobins from patients with amyotrophic lateral sclerosis affect human-erythrocyte acetylcholinesterase
54. Alzheimer's disease and Abeta toxicity: From top to bottom
55. Alzheimer's disease and acetylcholinesterase-containing neurons
56. Increased acetylcholinesterase activity in the CSF of Alzheimer patients carrying apolipoprotein epsilon4 allele
57. The recovery of acetylcholinesterase activity in the superior cervical ganglion of the rat following its inhibition by diisopropylphosphorofluoridate: A biochemical and cytochemical study
58. Acetylcholinesterase - new roles for an old actor
59. Acetylcholinesterase promotes regeneration of neurites in cultured adult neurons of Aplysia
60. The cause of neuronal degeneration in Alzheimer's disease
61. Non-cholinergic effects of acetylcholinesterase in the substantia nigra: A possible role for an ATP-sensitive potassium channel
62. Global and serial neurons form a hierarchically arranged interface proposed to underlie memory and cognition
63. Dysdifferentiation of structurally plastic neurons initiates the pathologic cascade of Alzheimer's disease: Toward a unifying hypothesis
64. Beta-Amyloid selectively augments NMDA receptor-mediated synaptic transmission in rat hippocampus
65. Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K