Bone marrow-derived mesenchymal stem cells decrease acute graft-versus-host disease after allogeneic hematopoietic stem cells transplantation

Immunological Investigations

Volumn 37, Issue 1, 2008, Pages 29-42

  Tian, Y ^a   Deng, Y B ^a   Huang, Y J ^a   Wang, Y ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Acute graft versus host disease; Allogeneic transplantation; Hematopoietic stem cells; Immunoregulation; Mesenchymal stem cells

Indexed keywords

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; DONOR; HOMEOSTASIS; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; TH2 CELL; THYMOCYTE;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CYTOKINES; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MICE; RATS; RATS, INBRED F344; RATS, WISTAR; T-LYMPHOCYTE SUBSETS; TRANSPLANTATION, HOMOLOGOUS;

EID: 38549147527     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.1080/08820130701410223     Document Type: Article

References (36)

1. Allen, R. D., Staley, T. A., Sidman, C. L. (1993). Differential cytokine expression in acute and chronic murine graft-versus-host-disease. Eur. J. Immunol. 23:333-337.
2. Annacker, O., Pimenta-Araujo, R., Burlen-Defranoux, O., et al. (2001). CD25(+)CD4(+) T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166(5):3008-3018.
3. Bartholomew, A., Sturgeon, C., Siatskas, M., et al. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp. Hematol. 30(1):42-48.
4. Cesaro, S., Oneto, R., Messina, C., et al. (2005). Haematopoietic stem cell transplantation for Shwachman-Diamond disease: a study from the European Group for blood and marrow transplantation. Br. J. Haematol. 131(2):231-236.
5. Cohen, J. L., Trenado, A., Vasey, D., et al. (2002). CD4(+)CD25(+) Immunoregulatory T Cells: New therapeutics for graft-versus-host disease. J. Exp. Med. 196(3):401-406.
6. Cooke, K. R., Kobzik, L., Martin, T. R., et al. (1996). An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88(8):3230-3239.
7. Di Nicola, M., Carlo-Stella, C., Magni, M., et al. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99(10):3838-3843.
8. Dieckmann, D., Plottner, H., Berchtold Berger, T., et al. (2001). Ex vivo isolation and characterization of CD4+CD25+ cells with regulatory properties from human blood. J. Exp. Med. 193: 1303-1310.
9. Edinger, M., Hoffmann, P., Ermann, J., et al. (2003). CD4(+)CD25(+) regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat. Med. 9(9):1144-1150.
10. Erdmann, A. A., Gao, Z. G., Jung, U., et al. (2005). Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo. Blood 105(12):4707-4714.
11. Ferrara, J. L. and Deeg, H. J. (1991). Graft-versus-host disease. N Engl J Med. 7;324(10):667-674.
12. Field, E. H., Matesic, D., Rigby, S., et al. (2001). CD4(+)CD25(+) regulate T cells in acquired MHC tolerance. Immunol. Rev. 182(Aug):99-112.
13. Frassoni, F., Labopin, M., Bacigalupo, A., et al. (2002). Expanded mesenchymal stem cells (MSC), coinfused with HLA identical hemapoietic stem cell transplants, reduce acute and chronic graft versus host disease: a matched pair analysis. Bone Marrow Transplant 29(suppl 2):s2.
14. Fowler, D. H., Kurasawa, K., Smith, R., et al. (1994). Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84(10):3540-3549.
15. Fowler, D. H. and Gress, R. E. (2000). Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk. Lymphoma 38(3-4):221-234.
16. Fowler, D. H., Bishop, M. R., Gress, R. E. (2004). Immunoablative reduced-intensity stem cell transplantation: potential role of donor Th2 and Tc2 cells. Semin. Oncol. 31(1):56-67.
17. Godfrey, W. R., Ge, Y. G., Spoden, D. J., Levine, B. L., June, C. H., Blazar, B. R., et al. (2004). In vitro-expanded human CD4+CD25+ Tregulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104:453-461.
18. Hoffmann, P., Ermann, J., Edinger, M., et al. (2002). Donor-type CD4(+)CD25(+) Regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J. Exp. Med. 196(3):389-399.
19. Jeong, D. C., Chung, N. G., and Kim, S. Y. (2003). MSC might prevent lethal GVHD in MHC mismatched murine allogeneic bone marrow transplantation [abstract]. Blood. 102(11):5369.
20. Klyushnenkova, E., Shustova, V., Mosca, J., et al. (1999). Human mesenchymal stem cells induce unresponsiveness in preactivated but not naive alloantigen specific T cells [abstract]. Exp Hematol. 27:122.
21. Koc, O. N., Gerson, S. L., Cooper, B. W., et al. (2000). Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J. Clin. Oncol. 18(2):307-316.
22. Krenger, W., Snyder, K. M., Byon, J. C., et al. (1995). Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease. J. Immunol. 15;155(2):585-593.
23. Lu, X. X., Liu, T., Meng, W. T., et al. (2005). Immune regulatory effect of human bone marrow mesenchymal stem cells on T lymphocyte. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13(4):651-655.
24. Maccario, R., Podesta, M., Moretta, A., et al. (2005). Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatorysuppressive phenotype. Haematologica. 90(4):516-525.
25. Maitra, B., Szekely, E., Gjini, K., et al. (2004). Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplantation 2004;33(6):597-604.
26. Noth, U., Osyczka, A. M., Tuli, R, et al. (2002). Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J. Orthop. Res. 20(5):1060-1069.
27. Pittenger, M. F., Mackay, A. M., Beck, S. C., et al. (1999). Multilineage potential of adult human mesenchymal stem cells. Science 284(5411):143-147.
28. Sakaguchi, S., Sakaguchi, N., Asano, M., et al. (1995). Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25) breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155(3):1151-1164.
29. Sakaguchi, S., Sakaguchi, N., Shimizu, J., et al. (2001). Immunologictolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 182:18-32.
30. Seebach, J. D., Stussi G, Passweg, J. R., et al. (2005). ABO blood group barrier in allogeneic bone marrow transplantation revisited. Biol. Blood Marrow Transplant. 11(12):1006-1013.
31. Shevach, E. M. Certified professionals: CD4(+)CD25(+) suppressor T cells. J. Exp. Med. 2001;193(11):F41-46.
32. Trenado, A., Charlotte, F., Fisson, S., et al. (2003). Recipient-type specific CD4+CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J. Clin. Invest. 112:1688-1696.
33. Tse, W. T., Pendleton, J. D., Beyer, W. M., Egalka, M. C., Guinan, E. C. (2003). Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implication in transplantation. Transplantation 75:389-397.
34. Wood, K. J., Sakaguchi, S. (2003). Regulatory T cells in transplantation tolerance. Nature Rev. Immunol. 3:199-210.
35. Xu, M. Q., Suo, Y. P., Gong, J. P., et al. (2004). Prolongation of liver allograft survival by dendritic cells modified with NF-B decoy oligodeoxynucleotides. World J. Gastroenterol, 10(16):2361-2368.
36. Zhao, D. C., Lei, J. X., Chen, R., et al. (2005). Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats. World J. Gastroenterol, 11(22):3431-3440.