Transcriptomal profiling of the cellular response to DNA damage mediated by Slug (Snai2)

British Journal of Cancer

Volumn 98, Issue 2, 2008, Pages 480-488

  Perez Caro M ^a   Bermejo Rodriguez C ^a   Gonzalez Herrero I ^a   Sanchez Beato M ^b   Piris, M A ^b   Sanchez Garcia I ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

DNA damage; MEFs; Microarray analysis; Snai2; Stem cells

Indexed keywords

DOXORUBICIN; PROTEIN P53; TRANSCRIPTION FACTOR SLUG;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; DNA DAMAGE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC LINKAGE; GROWTH DISORDER; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL PROLIFERATION; CELLS, CULTURED; DNA DAMAGE; DOXORUBICIN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENES, P53; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 38549145569     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604084     Document Type: Article

References (37)

1. Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T (2000) PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev 14(6): 704-718
2. Beattie JH, Wood AM, Newman AM, Bremner I, Choo KH, Michalska AE, Duncan JS, Trayhurn P (1998) Obesity and hyperleptinemia in metallothionein (-I and -II) null mice. Proc Natl Acad Sci USA 95(1): 358-363
3. Bermejo-Rodriguez C, Perez-Caro M, Perez-Mancera PA, Sanchez-Beato M, Piris MA, Sanchez-Garcia I (2006) Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts. Genomics 87(1): 113-118
4. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N (1995) Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 377(6550): 646-649
5. Burns TF, Bernhard EJ, El-Deiry WS (2001) Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 20(34): 4601-4612
6. Burns TF, El-Deiry WS (2003) Microarray analysis of p53 target gene expression patterns in the spleen and thymus in response to ionizing radiation. Cancer Biol Ther 2(4): 431-443
7. Castellanos A, Pintado B, Weruaga E, Arevalo R, Lopez A, Orfao A, Sanchez-Garcia I (1997) A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Blood 90(6): 2168-2174
8. Catalano A, Rodilossi S, Rippo MR, Caprari P, Procopio A (2004) Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. J Biol Chem 279: 46706-46714
9. Come C, Magnino F, Bibeau F, De Santa Barbara P, Becker KF, Theillet C, Savagner P (2006) Snail and slug play distinct roles during breast carcinoma progression. Clin Cancer Res 12(18): 5395-5402
10. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75(4): 817-825
11. Elloul S, Elstrand MB, Nesland JM, Trope CG, Kvalheim G, Goldberg I, Reich R, Davidson B (2005) Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 103(8): 1631-1643
12. Gupta PB, Kuperwasser C, Brunet JP, Ramaswamy S, Kuo WL, Gray JW, Naber SP, Weinberg RA (2005) The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet 37(10): 1047-1054
13. Haupt S, Alsheich-Bartok O, Haupt Y (2006) Clues from worms: a Slug at Puma promotes the survival of blood progenitors. Cell Death Differ 13(6): 913-9155
14. Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT (2002) Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2: 279-288
15. Inukai T, Inoue A, Kurosawa H, Goi K, Shinjyo T, Ozawa K, Mao M, Inaba T, Look AT (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol Cell 4(3): 343-352
16. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP (2003) Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4(4): 321-328
17. Jiang R, Lan Y, Norton CR, Sundberg JP, Gridley T (1998) The Slug gene is not essential for mesoderm or neural crest development in mice. Dev Biol 198(2): 277-285
18. Kajita M, McClinic KN, Wade PA (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol 24(17): 7559-7566
19. Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace Jr AJ (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71(4): 587-597
20. Katoh M, Katoh M (2004) Human FOX gene family. Int J Oncol 25(5): 1495-1500
21. Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J (2005) Genes that mediate breast cancer metastasis to lung. Nature 436(7050): 518-524
22. Nanda N, Iismaa SE, Owens WA, Husain A, Mackay F, Graham RM (2001) Targeted inactivation of Gh/tissue transglutaminase II. J Biol Chem 276(23): 20673-20678
23. Okamoto K, Beach D (1994) G is a transcriptional target of the p53 tumor suppressor protein. EMBO J 13(20): 4816-4822
24. Park SH, Cho HN, Lee SJ, Kim TH, Lee Y, Park YM, Lee YJ, Cho CK, Yoo SY, Lee YS (2000) Hsp25-induced radioresistance is associated with reduction of death by apoptosis: involvement of Bcl2 and the cell cycle. Radiat Res 154(4): 421-428
25. Perez-Caro M, Sanchez-Garcia I (2006) Killing time for cancer stem cells (CSC): discovery and development of selective CSC inhibitors. Curr Med Chem 13(15): 1719-1725
26. Pérez-Caro M, Pérez-Mancera P, Voces F, Sánchez-García I (2005) Of man in mouse: modelling human cancer genotype-phenotype correlations in mice. Curr Genomics 6: 81-88
27. Perez-Losada J, Sanchez-Martin M, Perez-Caro M, Perez-Mancera PA, Sanchez-Garcia I (2003) The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 22: 4205-4211
28. Perez-Losada J, Sanchez-Martin M, Rodriguez-Garcia A, Sanchez ML, Orfao A, Flores T, Sánchez-Garcia I (2002) Zincfinger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 100: 1274-1286
29. Perez-Mancera PA, Gonzalez-Herrero I, Maclean K, Turner AM, Yip MY, Sanchez-Martin M, Garcia JL, Robledo C, Flores T, Gutierrez-Adan A, Pintado B, Sanchez-Garcia I (2006) SLUG (SNAI2) overexpression in embryonic development. Cytogenet Genome Res 114(1): 24-29
30. Perez-Mancera PA, Gonzalez-Herrero I, Perez-Caro M, Gutierrez-Cianca N, Flores T, Gutierrez-Adan A, Pintado B, Sanchez-Martin M, Sanchez-Garcia I (2005) SLUG in cancer development. Oncogene 24(19): 3073-3082
31. Polyak K, Waldman T, He TC, Kinzler KW, Vogelstein B (1996) Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 10(15): 1945-1952
32. Sanchez-Garcia I 1997 Consequences of chromosomal abnormalities in tumor development. Annu Rev Genet 31: 429-453
33. Sanchez-Martin M, Gonzalez-Herrero I, Sanchez-Garcia I (2004) SNAI2 (SNAIL HOMOLOG 2). Atlas Genet Cytogenet Oncol Haematol April 2004. URL: http://atlasgeneticsoncology.org//Genes/SNAI2ID453.html
34. Sanchez-Martin M, Rodriguez-Garcia A, Perez-Losada J, Sagrera A, Read AP, Sanchez-Garcia I (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum Mol Genet 11(25): 3231-3236
35. Shih JY, Tsai MF, Chang TH, Chang YL, Yuan A, Yu CJ, Lin SB, Liou GY, Lee ML, Chen JJ, Hong TM, Yang SC, Su JL, Lee YC, Yang PC (2005) Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin Cancer Res 11(22): 8070-8078
36. Wang H, Wang JY, Johnson LR, Scott RE (1991) Selective induction of c-jun and jun-B but not c-fos or c-myc during mitogenesis in SV40-transformed cells at the predifferentiation growth arrest state. Cell Growth Differ 2(12): 645-652
37. Wu WS, Heinrichs S, Xu D, Garrison SP, Zambetti GP, Adams JM, Look AT (2005) Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123(4): 641-653