Therapy Insight: Metabolic and endocrine disorders in sickle cell disease

Nature Clinical Practice Endocrinology and Metabolism

Volumn 4, Issue 2, 2008, Pages 102-109

  Smiley, Dawn ^a   Dagogo Jack, Samuel ^b   Umpierrez, Guillermo ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

Endocrine disorders; Metabolic disorders; Sickle cell anemia

Indexed keywords

ANDROSTANOLONE; BILIRUBIN; CARBOHYDRATE; FERRITIN; FRUCTOSAMINE; HEMOGLOBIN A1C; INSULIN; IRON; ORAL ANTIDIABETIC AGENT; TESTOSTERONE; THYROTROPIN; VITAMIN D;

ADRENAL DISEASE; ANTIBIOTIC THERAPY; BONE DENSITY; CARBOHYDRATE INTOLERANCE; DIABETES MELLITUS; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDOCRINE DISEASE; ERYTHROCYTE TRANSFUSION; GROWTH CURVE; HEMOGLOBINOPATHY; HEMOLYTIC ANEMIA; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; INSULIN DEPENDENT DIABETES MELLITUS; IRON OVERLOAD; LIVER BIOPSY; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; SICKLE CELL ANEMIA; VITAMIN D DEFICIENCY;

ANEMIA, SICKLE CELL; ENDOCRINE SYSTEM DISEASES; ENERGY METABOLISM; HUMANS; HYPOTHYROIDISM; IRON OVERLOAD;

EID: 38549131708     PISSN: 17458366     EISSN: 17458374     Source Type: Journal    
DOI: 10.1038/ncpendmet0702     Document Type: Review

References (65)

1. Ballas SK (2002) Sickle cell anaemia: progress in pathogenesis and treatment. Drugs 62: 1143-1172
2. Wilson RE et al. (2003) Management of sickle cell disease in primary care. Clin Pediatr (Phila) 42: 753-761
3. Sickle Cell Disease Guideline Panel (1993) Sickle Cell Disease: Screening, Diagnosis, Management, and Counseling in Newborns and Infants. Clinical Practice Guideline No. 6. AHCPR Pub. No. 93-0562. Rockville, MD: Agency for Health Care Policy and Research, Public Health Service, US Department of Health and Human Services
4. Genes and Disease NCBI [http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call= bv.View..ShowSection&rid=gnd.section.98] (accessed 26 October 2007)
5. Olivieri NF (2001) Progression of iron overload in sickle cell disease. Semin Hematol 38 (Suppl 1): 57-62
6. Batts KP (2007) Iron overload syndromes and the liver. Modern Pathology 20 (Suppl 1): S31-S39
7. Walter PB et al. (2006) Oxidative stress and inflammation in iron-overloaded patients with β-thalassaemia or sickle cell disease. Br J Haematol 135: 254-263
8. Chatterjee R and Katz M (2000) Reversible hypogonadotrophic hypogonadism in sexually infantile male thalassaemic patients with transfusional iron overload. Clin Endocrinol (Oxf) 53: 33-42
9. Phillips G Jr et al. (1992) Hypothyroidism in adults with sickle cell anemia. Am J Med 92: 567-570
10. el-Hazmi MA et al. (1991) Endocrine functions in sickle cell anaemia patients. J Trop Pediatr 38: 307-313
11. Lukanmbi FA et al. (1986) Endocrine function and haemoglobinopathies: biochemical assessment of thyroid function in children with sickle cell disease. Afr J Med Med Sci 15: 25-28
12. Fung EB et al. (2006) Increased prevalence of iron-overload associated endocrinopathy in thalassaemia versus sickle cell disease. Br J Haematol 135: 574-582
13. Alustiza JM et al. (2007) Iron overload in the liver diagnostic and quantification. Eur J Radiol 61: 499-506
14. Harmatz P et al. (2000) Severity of iron overload in patients with sickle cell disease receiving chronic red blood cell transfusion therapy. Blood 96: 76-79
15. Martin DR and Semelka RC (2005) Magnetic resonance imaging of the liver: review of techniques and approach to common diseases. Semin Ultrasound CT MR 26: 116-131
16. Brittenham GM and Badman DG (2003) Noninvasive measurement of iron: report of an NIDDK workshop. Blood 101: 15-19
17. Prasad AS and Cossack ZT (1984) Zinc supplementation and growth in sickle cell disease. Ann Intern Med 100: 367-371
18. Soliman AT et al. (1999) Growth and pubertal development in transfusion-dependent children and adolescents with thalassaemia major and sickle cell disease: a comparative study. J Trop Pediatr 45: 23-30
19. Barden EM et al. (2002) Body composition in children with sickle cell disease. Am J Clin Nutr 76: 218-225
20. Thomas PW et al. (2000). Height and weight reference curves for homozygous sickle cell disease. Arch Dis Child 82: 204-208
21. Prasad AS (1997) Malnutrition in sickle cell disease patients. Am J Clin Nutr 66: 423-424
22. Hibbert JM et al. (2006) Erythropoiesis and myocardial energy requirements contribute to the hypermetabolism of childhood sickle cell anemia. J Pediatr Gastroenterol Nutr 43: 680-687
23. Akohoue SA et al. (2007) Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia. Pediatr Res 61: 233-238
24. Barden EM et al. (2002) Body composition in children with sickle cell disease. Am J Clin Nutr 76: 218-225
25. Soliman AT et al. (1997) Growth hormone secretion and circulating insulin-like growth factor-I (IGF-I) and IGF binding protein-3 concentrations in children with sickle cell disease. Metabolism 46: 1241-1245
26. Collett-Solberg PF et al. (2007) Short stature in children with sickle cell anemia correlates with alterations in the IGF-I axis. J Pediatr Endocrinol Metab 20: 211-218
27. Singhal A et al. (1997) Is there an energy deficiency in homozygous sickle cell disease? Am J Clin Nutr 66: 386-390
28. Balgir RS (1994) Age at menarche and first conception in sickle cell hemoglobinopathy. Indian Pediatr 31: 827-832
29. Abbiyesuku FM and Osotimehin BO (1999) Anterior pituitary gland assessment in sickle cell anaemia patients with delayed menarche. Afr J Med Med Sci 28: 65-69
30. Modebe O and Ezeh UO (1995) Effect of age on testicular function in adult males with sickle cell anemia. Fertil Steril 63: 907-912
31. Abbasi AA et al. (1976) Gonadal function abnormalities in sickle cell anemia. Studies in adult male patients. Ann Intern Med 85: 601-605
32. Reed JD et al. (1987) Nutrition and sickle cell disease. Am J Hematol 24: 441-455
33. Li M et al. (2003) Repeated testicular infarction in a patient with sickle cell disease: a possible mechanism for testicular failure. Urology 62: 551
34. Nahoum CR et al. (1980) Semen analysis in sickle cell disease. Andrologia 12: 542-545
35. Osegbe DN and Akinyanju OO (1987) Testicular dysfunction in men with sickle cell disease. Postgrad Med J 63: 95-98
36. Osegbe DN et al. (1981) Fertility in males with sickle cell disease. Lancet 2: 275-276
37. Osifo BO et al. (1988) Plasma cortisol in sickle cell disease. Acta Haematol 79: 44-45
38. Rosenbloom BE et al. (1980) Pituitary-adrenal axis function in sickle cell anemia and its relationship to leukocyte alkaline phosphatase. Am J Hematol 9: 373-379
39. Saad ST and Saad MJ (1992) Normal cortisol secretion in sickle cell anemia. Trop Geogr Med 44: 86-88
40. Reid HL et al. (1990) Insulin-dependent diabetes mellitus in homozygous sickle cell anaemia. Trop Geogr Med 42: 172-173
41. Mohapatra MK (2005) Type 1 diabetes mellitus in homozygous sickle cell anaemia. J Assoc Physicians India 53: 895-896
42. Alayash AI and al-Quorain A (1989) Prevalence of diabetes mellitus in individuals heterozygous and homozygous for sickle cell anemia. Clin Physiol Biochem 7: 87-92
43. Reid HL et al. (1992) Glycosylated haemoglobin HbA1c and HbS1c in non-diabetic Nigerians. Trop Geogr Med 44: 126-130
44. Schnedl WJ et al. (1999) HbA1c determination in patients with hemoglobinopathies. Diabetes Care 22: 368-369
45. Kosecki SM et al. (2005) Glycemic monitoring in diabetics with sickle cell plus β-thalassemia hemoglobinopathy. Ann Pharmacother 39: 1557-1560
46. Yahaya IA et al. (2006) Serum fructosamine in the assessment of glycaemic status in patients with sickle cell anaemia. Niger Postgrad Med J 13: 95-98
47. Panzer S et al. (1982) Glycosylated hemoglobins (GHb): an index of red cell survival. Blood 59: 1348-1350
48. Oerter KE et al. (1993) Multiple hormone deficiencies in children with hemochromatosis. J Clin Endocrinol Metab 76: 357-361
49. Parshad O et al. (1989) Abnormal thyroid hormone and thyrotropin levels in homozygous sickle cell disease. Clin Lab Haematol 11: 309-315
50. Ohene-Frempong K and Steinberg MH (2001) Clinical aspects of sickle cell anemia in adults and children. In Disorders of Hemoglobin: Genetics, Pathophysiology and Clinical Management, 641-670 (Eds Steinberg MH et al.) Cambridge, UK: Cambridge University Press
51. Barden EM et al. (2000) Total and resting energy expenditure in children with sickle cell disease. J Pediatr 136: 73-79
52. Buison AM et al. (2004) Low vitamin D status in children with sickle cell disease. J Pediatr 145: 622-627
53. Woods KF et al. (2001) Body composition in women with sickle cell disease. Ethn Dis 11: 30-35
54. Finan AC et al. (1988) Nutritional factors and growth in children with sickle cell disease. Am J Dis Child 142: 237-240
55. Chiu D et al. (1982) Peroxidation, vitamin E, and sickle cell anemia. Ann N Y Acad Sci 393: 323-335
56. Lal A et al. (2006) Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer 47: 901-906
57. Miller RG et al. (2006) High prevalence and correlates of low bone mineral density in young adults with sickle cell disease. Am J Hematol 81: 236-241
58. Fung EB et al. (2007) Markers of bone turnover are associated with growth and development in young subjects with sickle cell anemia. Pediatr Blood Cancer 135: 574-582
59. Almeida A and Roberts I (2005) Bone involvement in sickle cell disease. Br J Haematol 129: 482-490
60. Voskaridou E et al. (2005) Deferiprone as an oral iron chelator in sickle cell disease. Ann Hematol 84: 434-440
61. Kwiatkowski JL and Cohen AR (2004) Iron chelation therapy in sickle cell disease and other transfusion-dependent anemias. Hematol Oncol Clin North Am 18: 1355-1377, ix
62. Sklar CA et al. (1987) Adrenal function in thalassemia major following long-term treatment with multiple transfusions and chelation therapy. Evidence for dissociation of cortisol and adrenal androgen secretion. Am J Dis Child 141: 327-330
63. Bainbridge R et al. (1985) Clinical presentation of homozygous sickle cell disease. J Pediatr 106: 881-885
64. Platt OS et al. (1994) Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330: 1639-1644
65. Buchanan GR et al. (2004) Sickle cell disease. Hematology Am Soc Hematol Educ Program 35-47