Pre-clinical investigation of the efficacy of an artificial tear solution containing hydroxypropyl-guar as a gelling agent

Current Eye Research

Volumn 28, Issue 6, 2004, Pages 437-444

  Ubels, John L ^a,b   Clousing, Daniel P ^a   Van Haitsma, Timothy A ^a   Hong, Bor Shyue ^c   Stauffer, Peggy ^c   Asgharian, Bahram ^c   Meadows, David ^c  

^a CALVIN COLLEGE   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL TEAR; BENZALKONIUM CHLORIDE; CARBOXYFLUORESCEIN; CARBOXYMETHYLCELLULOSE; GELLING AGENT; GUAR GUM; MACROGOL 400; METHYLENE BLUE; POLYMER; PROPANE; PROPYLENE GLYCOL;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; CELL IMMORTALIZATION; CELL VIABILITY; COMPARATIVE STUDY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA PERMEABILITY; DESICCATION; EPITHELIUM CELL; EYE PROTECTION; EYELID; HUMAN; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RABBIT; TREATMENT OUTCOME;

ANIMALS; CELL LINE; CELL SURVIVAL; CELLULOSE; CORNEA; DESICCATION; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; DRY EYE SYNDROMES; EPITHELIAL CELLS; FLUORESCEINS; GALACTANS; HUMANS; HUMIDITY; MANNANS; METHYLENE BLUE; OPHTHALMIC SOLUTIONS; PLANT GUMS; POLYETHYLENE GLYCOLS; RABBITS;

EID: 4143069410     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680490503787     Document Type: Article

References (19)

1. Pezon E, Ricard A, Lafuma F, Audebert R. Reversible gel formation induced by ion complexation. 1. Borax-galactomannan interactions. Macromolecules. 1988;21:1121-1125.
2. Kasvan S, Prud'homme RK. Rheology of guar and HP-guar cross-linked by borate. Macromolecules. 1992;25:2026-2032.
3. Yamada M, Mochizuki H, Kawai M, Yoshino M, Mashima Y. Fluorometric measurement of pH in human tears in vivo. Curr Eye Res. 1997;16:482-186.
4. Nakamura M, Endo K-I, Nakata K, Hamano T. Gefarnate stimulates secretion of mucin-like glycoproteins by corneal epithelium in vitro and protects corneal epithelium from desiccation in vivo. Exp Eye Res. 1997;65:569-574.
5. Gamache DA, Wei Z-Y, Weimer LK, Miller ST, Spellman JM, Yanni JM. Corneal protection by the ocular mucin secretogogue 15(S)-HETE in a rabbit model of desiccation-induced corneal defect. J Ocular Pharmacol Ther. 2002;18:349-361.
6. Ubels JL, Aupperlee MD, Meadows DL. Artificial tear solutions and protection of the corneal epithelium from desiccation. J Toxicol - Cut Ocular Toxicol 2002;21:273-281.
7. Lopez Bernal D, Ubels JL. Artificial tear composition and promotion of recovery of the damaged corneal epithelium. Cornea. 1993;12:115-120.
8. Ubels JL, McCartney MD, Lantz WK, Beaird J, Dayalan A, Edelhauser HF. Effects of preservative-free artificial tear solutions on corneal epithelial structure and function. Arch Ophthalmol. 1995;113:371-378.
9. Burstein NL. Preservative alteration of corneal permeability in humans and rabbits. Invest Ophthalmol Vis Sci. 1984;25:1453-1457.
10. Araie M. Carboxyfluorescein. A dye for evaluating the corneal endothelial barrier function in vivo. Exp Eye Res. 1985;42:141-150.
11. Denizol F, Lang R. Rapid colorimetric assay for cell growth and survival - Modifications to the tetrazolium dye procedure giving improved sensitivity and selectivity. J Immunol Methods. 1989;89:271-277.
12. Offord EA, Sharif NA, Mace K, Tromvoukis Y, Spillare EA, Avanti O, Howe WE, Pfeifer MA. Immortalized human corneal epithelial cells for ocular toxicity and inflammation studies. Invest Ophthalmol Vis Sci. 1999;40:1091-1101.
13. Sharif NA, Wiernas TK, Howe WE, Griffin BW, Offord EA, Pfeifer MA. Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. Invest Ophthalmol Vis Sci. 1998;39:2562-2571.
14. Wong SC, Kilbourne ED. Production of infective virus in a variant of Chang conjunctival cells following infection with swine or N-WS influenza viruses. J Exp Med. 1961;113:95-110.
15. De Saint Jean M, Brignole F, Binguier A-F, Bauchet A, Feldmann G, Baudouin C. Effects of benzalkonium chloride on growth and survival of Chang conjunctival cells. Invest Ophthalmol Vis Sci. 1999;40:619-630.
16. Lavappa KS. Survey of ATCC stocks of human cell lines for HeLa contamination. In Vitro. 1978;14:469-475.
17. Wolosin JM. Regeneration of resistance and ion transport in rabbit corneal epithelium after induced surface cell exfoliation. J Membr Biol. 1988;104:45-55.
18. Lopez Bernal D, Ubels JL. Quantitative evaluation of the corneal epithelial barrier: Effect of artificial tears and preservatives. Curr Eye Res. 1991;10:645-656.
19. Christensen MT, Cohen S, Rinehart J, Akers F, Pemberton B, Bloomenstein M, Lesher M, Kaplan D, Meadows D, Meuse P, Hearn C, Stein JM. Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye. Curr Eye Res. 2004;28:55-62.