APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas Cohort)

Clinical Genetics

Volumn 59, Issue 5, 2001, Pages 316-324

  Pallaud, C ^a,b   Sass, C ^a,b   Zannad, F ^c   Siest, G ^a,b   Visvikis, Sophie ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

^c UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

Candidate genes; Cardiovascular disease; Healthy population; IMT; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ADENINE; ANGIOTENSIN; APOLIPOPROTEIN C3; ARGININE; CHOLESTEROL ESTER TRANSFER PROTEIN; CYTOSINE; FIBRINOGEN; GLYCOPROTEIN IIIA; GUANINE; HOMOCYSTEINE; ISOLEUCINE; LIPID; METHIONINE; RENIN; SERINE; THREONINE; THYMINE; VALINE;

ADULT; AMINO ACID METABOLISM; ARTERY INTIMA PROLIFERATION; ARTICLE; B SCAN; BLOOD VISCOSITY; CARDIOVASCULAR RISK; CAROTID ARTERY; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENDER; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE ADHERENCE; LIPID METABOLISM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR; THROMBOCYTE AGGREGATION;

ADULT; ALLELES; APOLIPOPROTEIN C-III; APOLIPOPROTEINS C; CARDIOVASCULAR DISEASES; CAROTID ARTERIES; CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; COHORT STUDIES; DNA; FEMALE; FIBRINOGEN; GENE FREQUENCY; GENES; GENETIC MARKERS; GLYCOPROTEINS; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC; TUNICA INTIMA; TUNICA MEDIA;

EID: 0035006125     PISSN: 00099163     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-0004.2001.590504.x     Document Type: Article

References (63)

1. Hodis HN, Mack WJ, La Bree L et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 1998: 128: 262-269.
2. Bots ML, Hoes AW, Koudstaal PJ et al. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997: 96: 1432-1437.
3. Iannuzzi A, Wilcosky T, Mercuri M et al. Ultrasonographic correlates of carotid atherosclerosis in transient ischemic attack and stroke. Stroke 1995: 26: 614-619.
4. Bonithon-Kopp C, Touboul PJ, Berr C et al. Relation of intima-media thickness to atherosclerotic plaques in carotid arteries. The Vascular Aging (EVA) Study. Arterioscler Thromb Vasc Biol 1996: 16: 310-316.
5. Gariepy J, Massonneau M, Levenson J et al. Evidence for in vivo carotid and femoral wall thickening in human hypertension. Groupe De Prevention Cardio-Vasculaire En Medecine Du Travail. Hypertension 1993: 22: 111-118.
6. Joensuu T, Salonen R, Winblad I et al. Determinants of femoral and carotid artery atherosclerosis. J Intern Med 1994: 236: 79-84.
7. Folsom AR, Eckfeldt JH, Weitzman S et al. Relation of carotid artery wall thickness to diabetes mellitus, fasting glucose and insulin, body size, and physical activity. Atherosclerosis Risk in Communities (ARIC) Study investigators. Stroke 1994: 25: 66-73.
8. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: a population-based ultrasonography study in eastern finnish men. J Intern Med 1991: 229: 225-231.
9. Sharrett AR, Patsch W, Sorlie PD et al. Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb 1994: 14: 1098-1104.
10. Malinow MR, Nieto FJ, Szklo M et al. Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 1993: 87: 1107-1113.
11. Lee AJ, Mowbray PI, Lowe GD et al. Blood viscosity and elevated carotid intima-media thickness in men and women: the Edinburgh Artery Study. Circulation 1998: 97: 1467-1473.
12. Folsom AR, Pankow JS, Williams RR et al. Fibrinogen, plasminogen activator inhibitor-1, and carotid intima-media wall thickness in the NHLBI Family Heart Study. Thromb Haemost 1998: 79: 400-404.
13. Zanchetti A, Bond MG, Hennig M et al. Risk factors associated with alterations in carotid intima-media thickness in hypertension: baseline data from the European Lacidipine Study on Atherosclerosis. J Hypertens 1998: 16: 949-961.
14. Karpe F, de Faire U, Mercuri M et al. Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men. Atherosclerosis 1998: 141: 307-314.
15. Foger B, Luef G, Ritsch A et al. Relationship of high-density lipoprotein subfractions and cholesteryl ester transfer protein in plasma to carotid artery wall thickness. J Mol Med 1995: 73: 369-372.
16. Bonithon-Kopp C, Ducimetiere P, Touboul PJ et al. Plasma angiotensin-converting enzyme activity and carotid wall thickening. Circulation 1994: 89: 952-954.
17. Duggirala R, Gonzalez VC, O'Leary DH et al. Genetic basis of variation in carotid artery wall thickness. Stroke 1996: 27: 833-837.
18. Zannad F, Visvikis S, Gueguen R et al. Genetics strongly determines the wall thickness of the left and right carotid arteries. Hum Genet 1998: 103: 183-188.
19. Sass C, Zannad F, Herbeth B et al. Apolipoprotein E4, lipoprotein lipase c447 and angiotensin-I converting enzyme deletion alleles were not associated with increased wall thickness of carotid and femoral arteries in healthy subjects from the Stanislas Cohort. Atherosclerosis 1998: 140: 89-95.
20. Tikkanen MJ, Viikari J, Akerblom HK, Pesonen E. Apolipoprotein B polymorphism and altered apolipoprotein B and low density lipoprotein cholesterol concentrations in Finnish children. Br Med J (Clin Res Ed) 1988: 296: 169-170.
21. Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res 1993: 34: 1255-1274.
22. Gudnason V, Thormar K, Humphries SE. Interaction of the cholesteryl ester transfer protein I405V polymorphism with alcohol consumption in smoking and non-smoking healthy men, and the effect on plasma HDL cholesterol and apoAI concentration. Clin Genet 1997: 51: 15-21.
23. Kakko S, Tamminen M, Paivansalo M et al. Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men. Eur J Clin Invest 2000: 30: 18-25.
24. Hegele RA, Connelly PW, Hanley AJ et al. Common genomic variation in the apoC3 promoter associated with variation in plasma lipoproteins. Arterioscler Thromb Vasc Biol 1997: 17: 2753-2758.
25. Xu CF, Talmud P, Schuster H et al. Association between genetic variation at the apo AI-CIII-AIV gene cluster and familial combined hyperlipidaemia. Clin Genet 1994: 46: 385 397.
26. Peacock RE, Hamsten A, Johansson J et al. Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses. Clin Genet 1994: 46: 273-282.
27. Peacock RE, Temple A, Gudnason V et al. Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from Iceland: interaction between genotype, gender, and smoking status. Genet Epidemiol 1997: 14: 265-282.
28. Surguchov AP, Page GP, Smith L et al. Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia. Arterioscler Thromb Vasc Biol 1996: 16: 941-947.
29. LaDu BN. Human serum paraoxonase/arylesterase. In: Kalow W, ed. Pharmacogenetics of Drug Metabolism. New York: Pergamon Press, 1992: 51-91.
30. Laplaud PM, Dantoine T, Chapman MJ. Paraoxonase as a risk marker for cardiovascular disease: facts and hypotheses. Clin Chem Lab Med 1998: 36: 431-441.
31. Cao H, Girard-Globa A, Serusclat A et al. Lack of association between carotid intima-media thickness and paraoxonase gene polymorphism in non-insulin dependent diabetes mellitus. Atherosclerosis 1998: 138: 361-366.
32. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med 1998: 49: 31-62.
33. Kang SS, Passen EL, Ruggie N et al. Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease. Circulation 1993: 88: 1463-1469.
34. Demuth K, Moatti N, Hanon O et al. Opposite effects of plasma homocysteine and the methylenetetrahydrofolate reductase C677T mutation on carotid artery geometry in asymptomatic adults. Arterioscler Thromb Vasc Biol 1998: 18: 1838-1843.
35. Arai K, Yamasaki Y, Kajimoto Y et al. Association of methylenetetrahydrofolate reductase gene polymorphism with carotid arterial wall thickening and myocardial infarction risk in NIDDM. Diabetes 1997: 46: 2102-2104.
36. Sebastio G, Sperandeo MP, Panico M et al. The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations. Am J Hum Genet 1995: 56: 1324-1333.
37. Benetos A, Topouchian J, Ricard S et al. Influence of angiotensin II type 1 receptor polymorphism on aortic stiffness in never-treated hypertensive patients. Hypertension 1995: 26: 44-47.
38. Castellano M, Muiesan ML, Beschi M et al. Angiotensin II type 1 receptor A/CI166 polymorphism, relationships with blood pressure and cardiovascular structure. Hypertension 1996: 28: 1076-1080.
39. Girerd X, Hanon O. Mourad JJ et al. Lack of association between renin-angiotensin system, gene polymorphisms, and wall thickness of the radial and carotid arteries. Hypertension 1998: 32: 579-583.
40. Gharavi AG, Lipkowitz ML, Diamond JA et al. Ambulatory blood pressure monitoring for detecting the relation between angiotensinogen gene polymorphism and hypertension. Am J Hypertens 1997: 10: 687-691.
41. Jeng JR. Left ventricular mass, carotid wall thickness, and angiotensinogen gene polymorphism in patients with hypertension. Am J Hypertens 1999: 12: 443-450.
42. Humphries SE, Ye S, Talmud P et al. European Atherosclerosis Research Study: genotype at the fibrinogen locus (G-455-A beta-gene) is associated with differences in plasma fibrinogen levels in young men and women from different regions in europe. Evidence for gender-genotype-environment interaction. Arterioscler Thromb Vasc Biol 1995: 15: 96-104.
43. Garg UC, Arnett DK, Folsom AR et al. Lack of association between platelet glycoprotein IIb/IIIa receptor PIA polymorphism and coronary artery disease or carotid intima-media thickness. Thromb Res 1998: 89: 85-89.
44. Wenzel K, Ernst M, Rohde K et al. DNA polymorphisms in adhesion molecule genes a new risk factor for early atherosclerosis. Hum Genet 1996: 97: 15-20.
45. Cheng S, Grow MA, Pallaud C et al. A multilocus genotyping assay for candidate markers of cardiovascular disease risk. Genome Res 1999: 9: 936-949.
46. Siest G, Visvikis S, Herbeth B et al. Objectives, design and recruitment of a familial and longitudinal cohort for studying gene-environment interactions in the field of cardiovascular risk: the Stanislas Cohort. Clin Chem Lab Med 1998: 36: 35-42.
47. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988: 16: 1215.
48. Cheng S, Pallaud C, Grow MA et al. A multilocus genotyping assay for cardiovascular disease. Clin Chem Lab Med 1998: 36: 561-566.
49. Voutilainen S, Alfthan G, Nyyssonen K et al. Association between elevated plasma total homocysteine and increased common carotid artery wall thickness. Ann Med 1998: 30: 300-306.
50. Woo KS, Chook P, Lolin YI et al. Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans (published erratum appears in Circulation Mar 28; 101: E116). Circulation 1997: 96: 2542-2544.
51. Bellamy MF, McDowell IF. Putative mechanisms for vascular damage by homocysteine. J Inherit Metab Dis 1997: 20: 307-315.
52. Dewey CF, Jr, Bussolari SR, Gimbrone MA, Jr, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng 1981: 103: 177-185.
53. Huynh TT, Davies MG, Trovato MJ et al. Alterations in wall tension and shear stress modulate tyrosine kinase signaling and wall remodeling in experimental vein grafts. J Vasc Surg 1999: 29: 334-344.
54. Bots ML, Hoes AW, Koudstaal PJ et al. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. Circulation 1997: 96: 1432-1437.
55. Bruce C, Sharp DS, Tall AR. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. J Lipid Res 1998: 39: 1071-1078.
56. Agellon LB, Walsh A, Hayek T et al. Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice. J Biol Chem 1991: 266: 10796-10801.
57. Zeiher AM, Schachlinger V, Hohnloser SH et al. Coronary atherosclerotic wall thickening and vascular reactivity in humans. Elevated high-density lipoprotein levels ameliorate abnormal vasoconstriction in early atherosclerosis. Circulation 1994: 89: 2525-2532.
58. Talmud PJ, Humphries SE. Apolipoprotein C-III gene variation and dyslipidaemia. Curr Opin Lipidol 1997: 8: 154-158.
59. Aalto-Setala K, Fisher EA, Chen X et al. Mechanism of hypertriglyceridemia in human apolipoprotein (apo) CIII transgenic mice. Diminished very low density lipoprotein fractional catabolic rate associated with increased apo CIII and reduced apo E on the particles. J Clin Invest 1992: 90: 1889-1900.
60. Sehayek E, Eisenberg S. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. J Biol Chem 1991: 266: 18259-18267.
61. Peacock RE, Temple A, Gudnason V et al. Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from iceland: interaction between genotype, gender, and smoking status. Genet Epidemiol 1997: 14: 265-282.
62. Dallongeville J, Meirhaeghe A, Cottel D et al. Gender related association between genetic variations of APOCIII gene and lipid and lipoprotein variables in northern France. Atherosclerosis 2000: 150: 149-157.
63. Ombres D, Pannitteri G, Montali A et al. The Gln-Arg192 polymorphism of human paraoxonase gene is not associated with coronary artery disease in Italian patients. Arterioscler Thromb Vasc Biol 1998: 18 (10): 1611-1616.