Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker

Journal of Immunology

Volumn 179, Issue 8, 2007, Pages 5169-5180

  Dráberová, Lubica ^a   Shaik, Gouse Mohiddin ^a   Volná, Petra ^a   Heneberg, Petr ^a,b   Tůmová, Magda ^a   Lebduška, Pavel ^a   Korb, Jan ^a   Dráber, Petr ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM CHANNEL; FC EPSILON IR PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN E RECEPTOR; LAT PROTEIN; PROTEIN KINASE SYK; PROTEIN LAT2; THAPSIGARGIN; UNCLASSIFIED DRUG; AMINO ACID TRANSPORTER; CD98 ANTIGEN; LAT2 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SLC7A8 PROTEIN, RAT; TYROSINE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; LEUKEMIA CELL; MAST CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; AMINO ACID SEQUENCE; ANIMAL; COMPARATIVE STUDY; IMMUNOLOGY; INTRACELLULAR FLUID; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANTIGENS, CD98 LIGHT CHAINS; CALCIUM; CALCIUM SIGNALING; CELL LINE, TUMOR; INTRACELLULAR FLUID; MAST CELLS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RATS; RECEPTORS, IGE; TYROSINE;

EID: 38449104425     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.8.5169     Document Type: Article

References (50)

1. Eiseman, E., and J. B. Bolen. 1992. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355: 78-80.
2. 1b in rat basophilic leukemia RBL-2H3 cells. J. Biol. Chem. 269: 5249-5254.
3. Parravicini, V., M. Gadina, M. Kovarova, S. Odom, C. Gonzalez-Espinosa, Y. Furumoto, S. Saitoh, L. E. Samelson, J. J. O'Shea, and J. Rivera. 2002. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat. Immunol. 3: 741-748.
4. Daëron, M., and R. Lesourne. 2006. Negative signaling in Fc receptor complexes. Adv. Immunol. 89: 39-86.
5. Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92.
6. Saitoh, S., R. Arudchandran, T. S. Manetz, W. Zhang, C. L. Sommers, P. E. Love, J. Rivera, and L. E. Samelson. 2000. LAT is essential for FcεRI-mediated mast cell activation. Immunity 12: 525-535.
7. Brdička, T., M. Imrich, P. Angelisová, N. Brdičková, O. Horváth, J. Špička, I. Hilgert, P. Lusková, P. Dráber, P. Novák, et al. 2002. Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling. J. Exp. Med. 196: 1617-1626.
8. Janssen, E., M. Zhu, W. Zhang, S. Koonpaew, and W. Zhang. 2003. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat. Immunol. 4: 117-123.
9. Tkaczyk, C., V. Horejsi, I. Shoko, P. Draber, L. E. Samelson, A. B. Satterthwaite, D. H. Nahm, D. D. Metcalfe, and A. M. Gilfillan. 2004. NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following kit activation and FcεRI aggregation. Blood 104: 207-214.
10. Volná, P., P. Lebduška, L. Dráberová, Š. Šímová, P. Heneberg, M. Boubelík, V. Bugajev, B. Malissen, B. S. Wilson, V. Hořejší, et al. 2004. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J. Exp. Med. 200: 1001-1013.
11. Zhu, M., Y. Liu, S. Koonpaew, O. Granillo, and W. Zhang. 2004. Positive and negative regulation of FcεRI-mediated signaling by adaptor protein LAB/NTAL. J. Exp. Med. 200: 991-1000.
12. 2+-regulating signal circuit in B lymphocytes. Immunity 21: 681-691.
13. Tolar, P., L. Dráberová, and P. Dráber. 1997. Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells. Eur. J. Immunol. 27: 3389-3397.
14. Dráberová, L., M. Amoui, and P. Dráber. 1996. Thy-1-mediated activation of rat mast cells: the role of Thy-1 membrane microdomains. Immunology 87: 141-148.
15. Tolar, P., M. Tůmová, and P. Dráber. 2001. New monoclonal antibodies recognizing the adaptor protein LAT. Folia Biol. 47: 215-217.
16. Rivera, J., J.-P. Kinet, J. Kim, C. Pucillo, and H. Metzger. 1988. Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E. Mol. Immunol. 25: 647-661.
17. b heavy chain haplotype. Eur. J. Immunol. 11: 527-529.
18. Liu, F.-T., J. W. Bohn, E. L. Ferry, H. Yamanoto, C. A. Molinaro, L. A. Sherman, N. R. Klinman, and D. H. Katz. 1980. Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization. J. Immunol. 124: 2728-2737.
19. Dráberová, L., and P. Dráber. 1991. Functional expression of the endogenous Thy-1 gene and the transfected murine Thy-1.2 gene in rat basophilic leukemia cells. Eur. J. Immunol. 21: 1583-1590.
20. Hálová, I., L. Dráberová, and P. Dráber. 2002. A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fcε receptor. Int. Immunol. 14: 213-223.
21. Yu, J. Y., S. L. DeRuiter, and D. L. Turner. 2002. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 99: 6047-6052.
22. Katoh, K., Y. Takahashi, S. Hayashi, and H. Kondoh. 1987. Improved mammalian vectors for high expression of G418 resistance. Cell Struct. Funct. 12: 575-580.
23. Surviladze, Z., L. Dráberová, M. Kovář ová, M. Boubelík, and P. Dráber. 2001. Differential sensitivity to acute cholesterol lowering of activation mediated via the high-affinity IgE receptor and Thy-1 glycoprotein. Eur. J. Immunol. 31: 1-10.
24. Howard, T. H., and W. H. Meyer. 1984. Chemotactic peptide modulation of actin assembly and locomotion in neutrophils. J. Cell Biol. 98: 1265-1271.
25. Dráberová, L., L. Dudková, M. Boubelík, H. Tolarová, F. Šmíd, and P. Dráber. 2003. Exogenous administration of gangliosides inhibits FcεRI-mediated mast cell degranulation by decreasing the activity of phospholipase Cγ. J. Immunol. 171: 3585-3593.
26. Amoui, M., P. Dráber, and L. Dráberová. 1997. Src family-selective tyrosine kinase inhibitor, PP1, inhibits both FcεRI- and Thy-1-mediated activation of rat basophilic leukemia cells. Eur. J. Immunol. 27: 1881-1886.
27. Wilson, B. S., J. R. Pfeiffer, and J. M. Oliver. 2000. Observing FcεRI signaling from the inside of the mast cell membrane. J. Cell Biol. 149: 1131-1142.
28. Dráberová, L., P. Lebduška, I. Hálová, P. Tolar, J. Štokrová, H. Tolarová, J. Korb, and P. Dráber. 2004. Signaling assemblies formed in mast cells activated via Fcε receptor I dimers. Eur. J. Immunol. 34: 2209-2219.
29. Dráberová, L. 1990. Cyclosporin A inhibits rat mast cell activation. Eur. J. Immunol. 20: 1469-1473.
30. Frigeri, L., and J. R. Apgar. 1999. The role of actin microfilaments in the downregulation of the degranulation response in RBL-2H3 cells. J. Immunol. 162: 2243-2250.
31. Tolarová, H., L. Dráberová, P. Heneberg, and P. Dráber. 2004. Involvement of filamentous actin in setting the threshold for degranulation in mast cells. Eur. J. Immunol. 34: 1627-1636.
32. lyn protein-tyrosine kinase. Proc. Natl. Acad. Sci. USA 91: 11251-11255.
33. Nishida, K., Y. Yoshida, M. Itoh, T. Fukada, T. Ohtani, T. Shirogane, T. Atsumi, M. Takahashi-Tezuka, K. Ishihara, M. Hibi, and T. Hirano. 1999. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 93: 1809-1816.
34. Wilson, B. S., J. R. Pfeiffer, Z. Surviladze, E. A. Gaudet, and J. M. Oliver. 2001. High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT. J. Cell Biol. 154: 645-658.
35. Hirasawa, N., A. Scharenberg, H. Yamamura, M. A. Beaven, and J. P. Kinet. 1995. A requirement for Syk in the activation of the microtubule-associated protein kinase/phospholipase A2 pathway by FcεRI is not shared by a G protein-coupled receptor. J. Biol. Chem. 270: 10960-10967.
36. Jabril-Cuenod, B., C. Zhang, A. M. Scharenberg, R. Paolini, R. Numerof, M. A. Beaven, and J. P. Kinet. 1996. Syk-dependent phosphorylation of Shc: a potential link between FcεRI and the Ras/mitogen-activated protein kinase signaling pathway through SOS and Grb2. J. Biol. Chem. 271: 16268-16272.
37. Kawakami, Y., J. Kitaura, L. Yao, R. W. McHenry, Y. Kawakami, A. C. Newton, S. Kang, R. M. Kato, M. Leitges, D. J. Rawlings, and T. Kawakami. 2003. A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc. Natl. Acad. Sci. USA 100: 9470-9475.
38. Putney, J. W., Jr., L. M. Broad, F. J. Braun, J. P. Lievremont, and G. S. Bird. 2001. Mechanisms of capacitative calcium entry. J. Cell Sci. 114: 2223-2229.
39. Thastrup, O., A. P. Dawson, O. Scharff, B. Foder, P. J. Cullen, B. K. Drobak, P. J. Bjerrum, S. B. Christensen, and M. R. Hanley. 1989. Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. Agents Actions 27: 17-23.
40. Heneberg, P., P. Lebduška, L. Dráberová, J. Korb, and P. Dráber. 2006. Topography of plasma membrane microdomains and its consequences for mast cell signaling. Eur. J. Immunol. 36: 2795-2806.
41. lyn are associated in large detergent-resistant complexes in rat basophilic leukemia cells. Proc. Natl. Acad. Sci. USA 90: 3611-3615.
42. Zhao, C., D. H. Yu, R. Shen, and G. S. Feng. 1999. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J. Biol. Chem. 274: 19649-19654.
43. Gu, H., K. Saito, L. D. Klaman, J. Shen, T. Fleming, Y. Wang, J. C. Pratt, G. Lin, B. Lim, J.-P. Kinet, and B. G. Neel. 2001. Essential role for Gab2 in the allergic response. Nature 412: 186-190.
44. Xie, Z. H., I. Ambudkar, and R. P. Siraganian. 2002. The adapter molecule Gab2 regulates FcεRI-mediated signal transduction in mast cells. J. Immunol. 168: 4682-4691.
45. Tailor, P., T. Jascur, S. Williams, M. von Willebrand, C. Couture, and T. Mustelin. 1996. Involvement of Src-homology-2-domain-containing protein-tyrosine phosphatase 2 in T cell activation. Eur. J. Biochem. 237: 736-742.
46. 2+ Influx. Curr. Biol. 15: 1235-1241.
47. 2+ channel function. J. Cell Biol. 169: 435-445.
48. Feske, S., Y. Gwack, M. Prakriya, S. Srikanth, S. H. Puppel, B. Tanasa, P. G. Hogan, R. S. Lewis, M. Daly, and A. Rao. 2006. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441: 179-185.
49. Putney, J. W., Jr. 2007. Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here). Cell Calcium 42: 103-110.
50. Gilfillan, A. M., and C. Tkaczyk. 2006. Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol. 6: 218-230.