Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control

Journal of Immunology

Volumn 179, Issue 9, 2007, Pages 5829-5838

  Hwang, Melissa L ^a   Lukens, John R ^a   Bullock, Timothy N J ^a,b  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CANCER CONTROL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL INFILTRATION; CELL MIGRATION; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC CELL; EXPOSURE; LYMPHOID TISSUE; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TUMOR GROWTH; VACCINIA; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CANCER TRANSPLANTATION; CELL LINE; CELL MOTION; CROSS PRESENTATION; CYTOLOGY; DISEASE COURSE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; NEOPLASM; PATHOLOGY;

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2;

ANIMALS; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CELL MOVEMENT; CROSS-PRIMING; DENDRITIC CELLS; DISEASE PROGRESSION; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; NEOPLASMS;

EID: 38449103182     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.9.5829     Document Type: Article

References (49)

1. Rosenberg, S. A., J. C. Yang, and N. P. Restifo. 2004. Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10: 909-915.
2. Whitmire, J. K., R. A. Flavell, I. S. Grewal, C. P. Larsen, T. C. Pearson, and R. Ahmed. 1999. CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. J. Immunol. 163: 3194-3201.
3. Franco, A., D. A. Tilly, I. Gramaglia, M. Croft, L. Cipolla, M. Meldal, and H. M. Grey. 2000. Epitope affinity for MHC class I determines helper requirement for CTL priming. Nat. Immunol. 1: 145-150.
4. + T cells. J. Immunol. 162: 3256-3262.
5. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, C. van Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180: 1263-1272.
6. + T cells. J. Immunol. 174: 710-717.
7. + T cell help. J. Exp. Med. 186: 65-70.
8. + T-helper and a T-killer cell. Nature 393: 474-478.
9. Schoenberger, S. P., R. E. Toes, E. I. van der Voort, R. Offringa, and C. J. Melief. 1998. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 393: 480-483.
10. + T cell memory. Science 297: 2060-2063.
11. Smith, K. A. 1984. Interleukin 2. Annu. Rev. Immunol. 2: 319-333.
12. D'Souza, W. N., and L. Lefrancois. 2003. IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J. Immunol. 171: 5727-5735.
13. + T lymphocytes. Nature 421: 852-856.
14. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
15. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
16. + memory T cells. Nature 441: 890-893.
17. + T-cell memory via TRAIL-mediated activation-induced cell death. Nature 434: 88-93.
18. Jennings, S. R., R. H. Bonneau, P. M. Smith, R. M. Wolcott, and R. Chervenak. 1991. CD4-positive T lymphocytes are required for the generation of the primary but not the secondary CD8-positive cytolytic T lymphocyte response to herpes simplex virus in C57BL/6 mice. Cell. Immunol. 133: 234-252.
19. Marzo, A. L., V. Vezys, K. D. Klonowski, S. J. Lee, G. Muralimohan, M. Moore, D. F. Tough, and L. Lefrancois. 2004. Fully functional memory CD8 T cells in the absence of CD4 T cells. J. Immunol. 173: 969-975.
20. -/- mice. J. Virol. 74: 9762-9765.
21. + T cells via antigen cross-presentation. J. Immunol. 176: 7288-7300.
22. + T cells have a major "post-licensing" role in CTL mediated anti-tumor immunity. J. Immunol. 165: 6047-6055.
23. + T cells by cognate helper T cells. J. Leukocyte Biol. 78: 879-887.
24. Wang, L., Y. Miyahara, T. Kato, L. Wang, T. Aota, K. Kuribayashi, and H. Shiku. 2003. Essential roles of tumor-derived helper T cell epitopes for an effective peptide-based tumor vaccine. Cancer Immun. 3: 16-28.
25. Ossendorp, F., E. Mengede, M. Camps, R. Filius, and C. J. Melief. 1998. Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. 187: 693-702.
26. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
27. Barnden, M. J., J. Allison, W. R. Heath, and F. R. Carbone. 1998. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76: 34-40.
28. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693-1702.
29. Bullock, T. N., T. A. Colella, and V. H. Engelhard. 2000. The density of peptides displayed by dendritic cells affects immune responses to human tyrosinase and gp100 in HLA-A2 transgenic mice. J. Immunol. 164: 2354-2361.
30. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J. Exp. Med. 189: 587-592.
31. - T cells. Eur. J. Immunol. 35: 3131-3141.
32. Moser, M., and K. M. Murphy. 2000. Dendritic cell regulation of Th1-Th2 development. Nat. Immunol. 1: 199-205.
33. Sadegh-Nasseri, S., and R. N. Germain. 1991. A role for peptide in determining MHC class II structure. Nature 353: 167-170.
34. Pu, Z., S. B. Lovitch, E. K. Bikoff, and E. R. Unanue. 2004. T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM. Immunity 20: 467-476.
35. Toldbod, H. E., R. Agger, L. Bolund, and M. Hokland. 2003. Potent influence of bovine serum proteins in experimental dendritic cell-based vaccination protocols. Scand. J. Immunol. 58: 43-50.
36. Mackey, M. F., Z. Wang, K. Eichelberg, and R. N. Germain. 2003. Distinct contributions of different CD40 TRAF binding sites to CD154-induced dendritic cell maturation and IL-12 secretion. Eur. J. Immunol. 33: 779-789.
37. Casares, N., J. J. Lasarte, A. L. de Cerio, P. Sarobe, M. Ruiz, I. Melero, J. Prieto, and F. Borras-Cuesta. 2001. Immunization with a tumor-associated CTL epitope plus a tumor-related or unrelated Th1 helper peptide elicits protective CTL immunity. Eur. J. Immunol. 31: 1780-1789.
38. Beuneu, H., Z. Garcia, and P. Bousso. 2006. Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells. J. Immunol. 177: 1406-1410.
39. + T cells to sites of CD4 T cell-dendritic cell interaction. Nature 440: 890-895.
40. Pan, J., M. D. Burdick, J. A. Belperio, Y. Y. Xue, C. Gerard, S. Sharma, S. M. Dubinett, and R. M. Strieter. 2006. CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis. J. Immunol. 176: 1456-1464.
41. Mikhak, Z., C. M. Fleming, B. D. Medoff, S. Y. Thomas, A. M. Tager, G. S. Campanella, and A. D. Luster. 2006. STAT1 in peripheral tissue differentially regulates homing of antigen-specific Th1 and Th2 cells. J. Immunol. 176: 4959-4967.
42. Hollenbaugh, J. A., and R. W. Dutton. 2006. IFN-γ regulates donor CD8 T cell expansion, migration, and leads to apoptosis of cells of a solid tumor. J. Immunol. 177: 3004-3011.
43. Arens, R., K. Tesselaar, P. A. Baars, G. M. van Schijndel, J. Hendriks, S. T. Pals, P. Krimpenfort, J. Borst, M. H. van Oers, and R. A. Van Lier. 2001. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNγ-mediated B cell depletion. Immunity 15: 801-812.
44. Borst, J., J. Hendriks, and Y. Xiao. 2005. CD27 and CD70 in T cell and B cell activation. Curr. Opin. Immunol. 17: 275-281.
45. + cytotoxic T lymphocytes in HIV-infected patients. J. Exp. Med. 200: 1407-1417.
46. + T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy. J. Immunol. 176: 7726-7735.
47. Tesselaar, K., L. A. Gravestein, G. M. van Schijndel, J. Borst, and R. A. Van Lier. 1997. Characterization of murine CD70, the ligand of the TNF receptor family member CD27. J. Immunol. 159: 4959-4965.
48. Oshima, H., H. Nakano, C. Nohara, T. Kobata, A. Nakajima, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, T. Muto, H. Yagita, and K. Okumura. 1998. Characterization of murine CD70 by molecular cloning and mAb. Int. Immunol. 10: 517-526.
49. + T cells. Forum 10: 256-270.