A monocyte-specific peptide from herpes simplex virus type 2 glycoprotein G activates the NADPH-oxidase but not chemotaxis through a G-protein-coupled receptor distinct from the members of the formyl peptide receptor family

Journal of Immunology

Volumn 179, Issue 9, 2007, Pages 6080-6087

  Bellner, Lars ^a,c   Karlsson, Jennie ^a   Fu, Huamei ^a   Boulay, François ^b   Dahlgren, Claes ^a   Eriksson, Kristina ^a,d   Karlsson, Anna ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CEA GRENOBLE   (France)

^c NEW YORK MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FORMYLPEPTIDE RECEPTOR; G PROTEIN COUPLED RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THROMBOSPONDIN; VIRUS GLYCOPROTEIN; GLYCOPROTEIN G, HERPES SIMPLEX VIRUS TYPE 2; LIGAND; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ARTICLE; CELL SPECIFICITY; CHEMOTAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; MONOCYTE; NEUTROPHIL; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; CHEMISTRY; CLASSIFICATION; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; SENSITIVITY AND SPECIFICITY;

AMINO ACID SEQUENCE; CHEMOTAXIS; ENZYME ACTIVATION; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MONOCYTES; NADPH OXIDASE; RECEPTOR CROSS-TALK; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, G-PROTEIN-COUPLED; SENSITIVITY AND SPECIFICITY; VIRAL ENVELOPE PROTEINS;

EID: 38449083897     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.9.6080     Document Type: Article

References (41)

1. Wald, A., J. Zeh, S. Selke, R. L. Ashley, and L. Corey. 1995. Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 333: 770-775.
2. Wald, A., J. Zeh, S. Selke, T. Warren, A. J. Ryncarz, R. Ashley, J. N. Krieger, and L. Corey. 2000. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N. Engl. J. Med. 342: 844-850.
3. Milligan, G. N. 1999. Neutrophils aid in protection of the vaginal mucosae of immune mice against challenge with herpes simplex virus type 2. J. Virol. 73: 6380-6386.
4. Altamura, M., M. G. Geronimo, L. Nappi, O. Ceci, P. Loizzi, and E. Jirillo. 1997. Successful treatment of herpes simplex virus (HSV) recurrent genital infection with recombinant human (rh) granulocyte-macrophage colony stimulating factor (GM-CSF): a case report. Immunopharmacol. Immunotoxicol. 19: 425-436.
5. Bellner, L., F. Thoren, E. Nygren, J. A. Liljeqvist, A. Karlsson, and K. Eriksson. 2005. A proinflammatory peptide from herpes simplex virus type 2 glycoprotein G affects neutrophil, monocyte, and NK cell functions. J. Immunol. 174: 2235-2241.
6. Le, Y., P. M. Murphy, and J. M. Wang. 2002. Formyl-peptide receptors revisited. Trends Immunol. 23: 541-548.
7. Su, S. B., W. H. Gong, J. L. Gao, W. P. Shen, M. C. Grimm, X. Deng, P. M. Murphy, J. J. Oppenheim, and J. M. Wang. 1999. T20/DP178, an ectodomain peptide of human immunodeficiency virus type 1 gp41, is an activator of human phagocyte N-formyl peptide receptor. Blood 93: 3885-3892.
8. Fu, H., J. Karlsson, J. Bylund, C. Movitz, A. Karlsson, and C. Dahlgren. 2006. Ligand recognition and activation of formyl peptide receptors in neutrophils. J. Leukocyte Biol. 79: 247-256.
9. Migeotte, I., E. Riboldi, J. D. Franssen, F. Gregoire, C. Loison, V. Wittamer, M. Detheux, P. Robberecht, S. Costagliola, G. Vassart, et al. 2005. Identification and characterization of an endogenous chemotactic ligand specific for FPRL2. J. Exp. Med. 201: 83-93.
10. Sheppard, F. R., M. R. Kelher, E. E. Moore, N. J. McLaughlin, A. Banerjee, and C. C. Silliman. 2005. Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J. Leukocyte Biol. 78: 1025-1042.
11. Hellstrand, K., and S. Hermodsson. 1993. Serotonergic 5-HT1A receptors regulate a cell contact-mediated interaction between natural killer cells and monocytes. Scand. J. Immunol. 37: 7-18.
12. Djordjevic, V. B. 2004. Free radicals in cell biology. Int. Rev. Cytol. 237: 57-89.
13. Betten, A., C. Dahlgren, S. Hermodsson, and K. Hellstrand. 2003. Histamine inhibits neutrophil NADPH oxidase activity triggered by the lipoxin A4 receptor-specific peptide agonist Trp-Lys-Tyr-Met-Val-Met. Scand. J. Immunol. 58: 321-326.
14. Betten, A., C. Dahlgren, U. H. Mellqvist, S. Hermodsson, and K. Hellstrand. 2004. Oxygen radical-induced natural killer cell dysfunction: role of myeloperoxidase and regulation by serotonin. J. Leukocyte Biol. 75: 1111-1115.
15. Dall'Olio, F., N. Malagolini, G. Campadelli-Fiume, and F. Serafini-Cessi. 1987. Glycosylation pattern of herpes simplex virus type 2 glycoprotein G from precursor species to the mature form. Arch. Virol. 97: 237-249.
16. Balachandran, N., and L. M. Hutt-Fletcher. 1985. Synthesis and processing of glycoprotein gG of herpes simplex virus type 2. J. Virol. 54: 825-832.
17. Marsden, H. S., A. Buckmaster, J. W. Palfreyman, R. G. Hope, and A. C. Minson. 1984. Characterization of the 92,000-dalton glycoprotein induced by herpes simplex virus type 2. J. Virol. 50: 547-554.
18. Su, H. K., R. Eberle, and R. J. Courtney. 1987. Processing of the herpes simplex virus type 2 glycoprotein gG-2 results in secretion of a 34,000-Mr cleavage product. J. Virol. 61: 1735-1737.
19. McGeoch, D. J. 1987. The genome of herpes simplex virus: structure, replication and evolution. J. Cell Sci. Suppl. 7: 67-94.
20. Levi, M., U. Ruden, and B. Wahren. 1996. Peptide sequences of glycoprotein G-2 discriminate between herpes simplex virus type 2 (HSV-2) and HSV-1 antibodies. Clin. Diagn. Lab. Immunol. 3: 265-269.
21. Cunningham, C. C., R. Vegners, R. Bucki, M. Funaki, N. Korde, J. H. Hartwig, T. P. Stossel, and P. A. Janmey. 2001. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J. Biol. Chem. 276: 43390-43399.
22. Hansson, M., A. Asea, U. Ersson, S. Hermodsson, and K. Hellstrand. 1996. Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites. J. Immunol. 156: 42-47.
23. Boyum, A., D. Lovhaug, L. Tresland, and E. M. Nordlie. 1991. Separation of leucocytes: improved cell purity by fine adjustments of gradient medium density and osmolality. Scand. J. Immunol. 34: 697-712.
24. Christophe, T., A. Karlsson, M. J. Rabiet, F. Boulay, and C. Dahlgren. 2002. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/ LXA4R, is not affected by lipoxin A4. Scand. J. Immunol. 56: 470-476.
25. Dahlgren, C., T. Christophe, F. Boulay, P. N. Madianos, M. J. Rabiet, and A. Karlsson. 2000. The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor. Blood 95: 1810-1818.
26. Dahlgren, C., and A. Karlsson. 1999. Respiratory burst in human neutrophils. J. Immunol. Methods 232: 3-14.
27. Foyouzi-Youssefi, R., F. Petersson, D. P. Lew, K. H. Krause, and O. Nusse. 1997. Chemoattractant-induced respiratory burst: increases in cytosolic Ca2+ concentrations are essential and synergize with a kinetically distinct second signal. Biochem. J. 322 (Pt. 3): 709-718.
28. Dahlgren, C., A. Karlsson, and J. Bylund. 2007. Measurement of respiratory burst products generated by professional phagocytes. Methods Mol. Biol. 138: 349-363.
29. Christophe, T., A. Karlsson, C. Dugave, M. J. Rabiet, F. Boulay, and C. Dahlgren. 2001. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J. Biol. Chem. 276: 21585-21593.
30. Hartt, J. K., G. Barish, P. M. Murphy, and J. L. Gao. 1999. N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes: molecular characterization of FPR2, a second mouse neutrophil FPR. J. Exp. Med. 190: 741-747.
31. Fu, H., L. Bjorkman, P. Janmey, A. Karlsson, J. Karlsson, C. Movitz, and C. Dahlgren. 2004. The two neutrophil members of the formylpeptide receptor family activate the NADPH-oxidase through signals that differ in sensitivity to a gelsolin derived phosphoinositide-binding peptide. BMC Cell. Biol. 5: 50.
32. Heit, B., S. Tavener, E. Raharjo, and P. Kubes. 2002. An intracellular signaling hierarchy determines direction of migration in opposing chemotactic gradients. J. Cell Biol. 159: 91-102.
33. Fu, H., J. Bylund, A. Karlsson, S. Pellme, and C. Dahlgren. 2004. The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. Immunology 112: 201-210.
34. Ye, R. D., S. L. Cavanagh, O. Quehenberger, E. R. Prossnitz, and C. G. Cochrane. 1992. Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun. 184: 582-589.
35. Boulay, F., M. Tardif, L. Brouchon, and P. Vignais. 1990. The human N-formylpeptide receptor: characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry 29: 11123-11133.
36. Selvatici, R., S. Falzarano, A. Mollica, and S. Spisani. 2006. Signal transduction pathways triggered by selective formylpeptide analogues in human neutrophils. Eur. J. Pharmacol. 534: 1-11.
37. Palmblad, J., C. L. Malmsten, A. M. Uden, O. Radmark, L. Engstedt, and B. Samuelsson. 1981. Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. Blood 58: 658-661.
38. Karlsson, J., H. Fu, F. Boulay, C. Dahlgren, K. Hellstrand, and C. Movitz. 2005. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J. Leukocyte Biol. 78: 762-771.
39. Neumann, J., A. M. Eis-Hubinger, and N. Koch. 2003. Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion. J. Immunol. 171: 3075-3083.
40. Hill, A., P. Jugovic, I. York, G. Russ, J. Bennink, J. Yewdell, H. Ploegh, and D. Johnson. 1995. Herpes simplex virus turns off the TAP to evade host immunity. Nature 375: 411-415.
41. Hill, A. B., B. C. Barnett, A. J. McMichael, and D. J. McGeoch. 1994. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types 1 and 2. J. Immunol. 152: 2736-2741.