Are there benefits to a fresh whole blood vs. packed red blood cell cardiopulmonary bypass prime on outcomes in neonatal and pediatric cardiac surgery?

Journal of Extra-Corporeal Technology

Volumn 39, Issue 3, 2007, Pages 168-176

  Valleley, Melinda S ^a,c   Buckley, Klayton W ^a   Hayes, Kylie M ^a   Fortuna, Randall R ^a   Geiss, Dale M ^a   Holt, David W ^b  

^a Children's Hospital of Illinois   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c Children's Hospital Omaha   (United States)

Author keywords

Cardiopulmonary bypass; Fresh whole blood; Pediatric perfusion circuitry; Pre bypass ultrafiltration

Indexed keywords

ARTICLE; BLOOD; CARDIOPULMONARY BYPASS; COMPARATIVE STUDY; ERYTHROCYTE CONCENTRATE; EXTUBATION; FATALITY; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; NEWBORN SURGERY; OUTCOMES RESEARCH; PEDIATRIC SURGERY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE HEMORRHAGE; BLOOD TRANSFUSION; CARDIOVASCULAR SURGERY; CHILD; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; INFANT; MALE; METHODOLOGY; NEWBORN; OUTCOME ASSESSMENT; PLASMA; PRESCHOOL CHILD; STATISTICS; TREATMENT OUTCOME; UNITED STATES;

BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CARDIOVASCULAR SURGICAL PROCEDURES; CHILD; CHILD, PRESCHOOL; COMORBIDITY; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; NEBRASKA; OUTCOME ASSESSMENT (HEALTH CARE); PLASMA; POSTOPERATIVE COMPLICATIONS; TREATMENT OUTCOME;

EID: 38449083454     PISSN: 00221058     EISSN: 29698960     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Keidan I, Amir G, Mandel M, Mishali D. The metabolic effects of fresh versus old stored blood in the priming of cardiopulmonary bypass solution for pediatric patients. J Thorac Cardiovasc Surg. 2004;127:949-52.
2. Manno CS, Hedberg KW, Kim HC, Bunin GR, Nicolson S, Jobes D. Comparison of the hemostatic effects of fresh whole blood, stored whole blood, and components after open heart surgery in children. Blood. 1991;77:930-6.
3. Mou SS, Giroir BP, Molitor-Kirsch EA, et al. Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants. N Engl J Med. 2004;351:1635-44.
4. Friesen RH, Perryman KM, Weigers KR, Mitchell MB, Friesen RM. A trial of fresh autologous whole blood to treat dilutional coagulopathy following cardiopulmonary bypass in infants. Pediatr Anesth. 2006;16:429-35.
5. Shimpo H, Shimamoto A, Miyake Y, et al. Effect of ultrafiltration on priming solution with preserved blood for extracorporeal circulation in infants. ASAIO J. 1996;42:M792-4.
6. Nagashima M, Imai Y, Seo K, et al. Effect of hemofiltered whole blood pump priming on hemodynamics and respiratory function after the arterial switch operation in neonates. Ann Thorac Surg. 2000;70:1901-6.
7. Shimpo H, Shimamoto A, Sawamura Y, et al. Ultrafiltration of the priming blood before cardiopulmonary bypass attenuates inflammatory response and improves postoperative clinical course in pediatric patients. Shock. 2001;16(Supp1):51-4.
8. Ridley PD, Ratcliffe JM, Alberti KGMM, Elliot MJ. The metabolic consequence of a "washed" cardiopulmonary bypass pump-priming fluid in children undergoing cardiac operations. J Thorac Cardiovasc Surg. 1990;100:528-37.
9. Shen I, Giacomuzzi C, Ungerleider RM. Current strategies for optimizing the use of cardiopulmonary bypass in neonates and infants. Ann Thorac Surg. 2003;75:S729-34.
10. Ratcliffe JM, Elliot MJ, Wyse RK, Alberti KG. The metabolic load of stored blood. Implications for major transfusions in infants. Arch Dis Child. 1986;61:1208-14.
11. Madhok AB, Ojamaa K, Haridas V, Parnell VA, Pahwa S, Chowdhury D. Cytokine response in children undergoing surgery for congenital heart disease. Pediatr Cardiol. 2006;27:408-13.
12. Guay J, Moerloose P, Lasne D. Minimizing perioperative blood loss and transfusions in children. Can J Anesth. 2006;53:S59-67.
13. Williams GD, Bratton SL, Ramamoorthy C. Factors associated with blood loss and blood product transfusions: a multivariate analysis in children after open-heart surgery. Anesth Analg. 1999;89:57-64.
14. Lithmathe J, Boeken U, Feindt P, Gams E. Predictors of homologous blood transfusions for patients undergoing open heart surgery. Thorac Cardiovasc Surg. 2003;51:17-21.
15. Spiess BD. Blood transfusion: the silent epidemic. Ann Thorac Surg. 2001;72:S1832-7.
16. Spiess BD. Transfusion of blood products affects outcome in cardiac surgery. Semin Cardiothrorac Vasc Anesth. 2004;8:267-81.
17. Elward AM, Fraser VJ. Risk factors for noscomial primary bloodstream infection in pediatric intensive care unit patients: a 2-year prospective cohort study. Infect Control Hosp Epidemiol. 2006;27:553-60.
18. Ottino G, De Paulis R, Pansini S, et al. Major sternal wound infection after open-heart surgery: a multivariate analysis of risk factors in 2,579 consecutive operative procedures. Ann Thorac Surg. 1987;44:173-9.
19. Shander A. Emerging risks and outcomes of blood transfusion in surgery. Semin Hematol. 2004;41:117-24.
20. Kwiatkowski JL, Manno CS. Blood transfusion support in pediatric cardiovascular surgery. Transfus Sci. 1999;21:63-72.
21. Mohr R, Martinowitz U, Lavee J, Amroch D, Ramot B, Goor DA. The hemostatic effect of transfusing fresh whole blood versus platelet concentrates after cardiac operations. J Thorac Cardiovasc Surg. 1988;96:530-4.
22. Mohr R, Goor DA, Yellin A, Moshkovitz Y, Shinfeld A, Martinowitz U. Fresh blood units contain large potent platelets that improve hemostasis after open heart operations. Ann Thorac Surg. 1992;53:650-4.
23. Zallen G, Offner PJ, Moore EE, et al. Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg. 1999;178:570-2.
24. Basran S, Frumento RJ, Cohen A, et al. The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg. 2006;103:15-20.
25. Guay J, Rivard GE. Mediastinal bleeding after cardiopulmonary bypass in pediatric patients. Ann Thorac Surg. 1996;62:1955-60.