Pharmacogenomics: Analysing SNPs in the CYP2D6 gene using amino acid properties

International Journal of Bioinformatics Research and Applications

Volumn 3, Issue 4, 2007, Pages 471-479

  Ebbert, Mark T W ^a   Beckstead, Wesley A ^a   O'Connor, Timothy D ^a   Clement, Mark J ^b   McClellan, David A ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

^b 3361 TMCB   (United States)

Author keywords

Amino acid properties; Bioinformatics; CYP2D6 gene; Pharmacogenomics; Single nucleotide polymorphisms; SNPs

Indexed keywords

CYTOCHROME P450 2D6; AMINO ACID; PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BIOCHEMISTRY; BIOINFORMATICS; CARBOXY TERMINAL SEQUENCE; DRUG METABOLISM; HYDROPHOBICITY; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; SINGLE NUCLEOTIDE POLYMORPHISM; THERMODYNAMICS; BIOLOGY; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; GENOMICS; HUMAN; METHODOLOGY; MOLECULAR GENETICS; MUTATION; PHARMACOGENETICS; PHYSIOLOGY;

AMINO ACIDS; BASE SEQUENCE; COMPUTATIONAL BIOLOGY; CYTOCHROME P-450 CYP2D6; GENE EXPRESSION REGULATION; GENOMICS; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHARMACOGENETICS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

EID: 38449083333     PISSN: 17445485     EISSN: 17445493     Source Type: Journal    
DOI: 10.1504/IJBRA.2007.015415     Document Type: Article

References (12)

1. Evans, W. and Relling, M. (1999) 'Pharmacogenomics: translating functional genomics into rational therapeutics', Science, Vol. 286, pp.487, 491.
2. Expasy (2006) CP2D6_HUMAN, Retrieved May 12, from http://ca.expasy.org/cgi-bin/niceprot.pl?P10635.
3. Kalow, W. (2006) 'Pharmacogenetics and pharmacogenomics: origin, status and the hope for personalized medicine', The Pharmacogenomics Journal, Vol. 6, pp.162-165, doi: 10.1038/sj.tpj.6500361; published online 17, http://www.nature.com/tpj/journal/v6/n3/abs/6500361a.html.
4. Kumar, S., Tamura, K. and Nei, M. (1994) 'MEGA: molecular evolutionary genetics analysis software for microcomputers', Comput. Appl. Biosci., Vol. 10, pp.189-191.
5. Levo, A., Koski, A., Ojanpera, I., Vuori, E. and Sajantila, A. (2003) 'Post-mortem SNP analysis of CYP2D6 gene reveals correlation between genotype and opioid drug (tramadol) metabolite ratios in blood', Forensic Science International, Vol. 135, pp.9-15.
6. McClellan, D., Palfreyman, E., Smith, M., Moss, J., Christensen, R. and Sailsbery, J. (2005) 'Physicochemical evolution and molecular adaptation of the cetacean and artiodactyls cytochrome b proteins', Mol. Biol. Evol., Vol. 22, pp.437-455.
7. McClellan, D.A. and McCracken, K.G. (2001) 'Estimating the influence of selection on the variable amino acids sites of the cytochrome b protein functional domains', Mol. Biol. Evol., Vo. 18, pp.917-925.
8. Medentz, I., Wong, W., Berti, L., Shiow, L., Tom, J., Scherer, J., Sensabaugh, G. and Mathies, R. (2001) 'High-performance multiplex SNP analysis of three hemochromatosis-related mutations with capillary array electrophoresis microplates', Genome Research, Vol. 11, pp.413-421.
9. Stipp, D. (2000) 'A DNA tragedy', Fortune, Vol. 142, No. 10, pp.170-178.
10. Syvänen, A. and Söderlund, H. (2002) 'DNA sandwiches with silver and gold', Nature Biotechnology, Vol. 20, pp.349, 350.
11. Woolley, S., Johnson, J., Smith, M., Crandall, K. and McClellan, D. (2003) 'TreeSAAP: selection on amino acid properties using phylogenetic trees', Bioinformatics, Vol. 19, No. 5, pp.671, 672.
12. Yang, Z. (1997) 'PAML: a program package for phylogenetic análisis by maximum likelihood', CABIOS, Vol. 13, pp.555, 556.