Role of epigenetics in mental disorders

Australian and New Zealand Journal of Psychiatry

Volumn 42, Issue 2, 2008, Pages 97-107

  Stuffrein Roberts, Selma ^a   Joyce, Peter R ^a   Kennedy, Martin A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Differential allele expression; Epigenetics; Gene regulation

Indexed keywords

BETAINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINE; CYANOCOBALAMIN; FOLIC ACID; METHIONINE; METHYL CPG BINDING PROTEIN 2; MONOAMINE OXIDASE INHIBITOR; REELIN; SEROTONIN 2A RECEPTOR; TRANYLCYPROMINE; VALPROIC ACID;

BEHAVIOR CHANGE; CLINICAL TRIAL; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; DRUG MECHANISM; ENVIRONMENTAL EXPOSURE; EPIGENETICS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; MATERNAL BEHAVIOR; MENTAL DISEASE; NONHUMAN; NUTRITIONAL STATUS; PHENOTYPE; PSYCHOSIS; REVIEW; SEX DIFFERENCE;

CHROMATIN; CPG ISLANDS; CYTOSINE; DEPRESSIVE DISORDER; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; MENTAL DISORDERS; MONOAMINE OXIDASE INHIBITORS; PHARMACOGENETICS;

EID: 38349166904     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1080/00048670701787495     Document Type: Review

References (103)

1. Ridley, M. (2003) Nature via nurture: Genes, experience, and what makes us human, HarperCollins Publishers, New York
2. Kendler, KS and Baker, JH. (2007) Genetic influences on measures of the environment: A systematic review. Psychol Med, 37, pp. 615-626.
3. Caspi, A., Sugden, K. and Moffitt, TE (2003) Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, pp. 386-389.
4. Lo, HS, Wang, Z. and Hu, Y. (2003) Allelic variation in gene expression is common in the human genome. Genome Res, 13, pp. 1855-1862.
5. Bray, NJ, Buckland, PR, Owen, MJ and O'Donovan, MC. (2003) Cis-acting variation in the expression of a high proportion of genes in human brain. Hum Genet, 113, pp. 149-153.
6. Yan, H., Yuan, W., Velculescu, VE, Vogelstein, B. and Kinzler, KW. (2002) Allelic variation in human gene expression. Science, 297, p. 1143.
7. Cowles, CR, Hirschhorn, JN, Altshuler, D. and Lander, ES. (2002) Detection of regulatory variation in mouse genes. Nat Genet, 32, pp. 432-437.
8. Felsenfeld, G. and Groudine, M. (2003) Controlling the double helix. Nature, 421, pp. 448-453.
9. Marks, P., Rifkind, RA, Richon, VM, Breslow, R., Miller, T. and Kelly, WK. (2001) Histone deacetylases and cancer: Causes and therapies. Nat Rev Cancer, 1, pp. 194-202.
10. Kornberg, RD and Lorch, Y. (1999) Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell, 98, pp. 285-294.
11. Luger, K., Rechsteiner, TJ, Flaus, AJ, Waye, MM and Richmond, TJ. (1997) Characterization of nucleosome core particles containing histone proteins made in bacteria. J Mol Biol, 272, pp. 301-311.
12. Spencer, VA and Davie, JR. (1999) Role of covalent modifications of histones in regulating gene expression. Gene, 240, pp. 1-12.
13. Strahl, BD and Allis, CD. (2000) The language of covalent histone modifications. Nature, 403, pp. 41-45.
14. Berger, SL. (2002) Histone modifications in transcriptional regulation. Curr Opin Genet Dev, 12, pp. 142-148.
15. Hans, F. and Dimitrov, S. (2001) Histone H3 phosphorylation and cell division. Oncogene, 20, pp. 3021-3027.
16. Nowak, SJ and Corces, VG. (2004) Phosphorylation of histone H3: A balancing act between chromosome condensation and transcriptional activation. Trends Genet, 20, pp. 214-220.
17. Loizou, JI, Murr, R., Finkbeiner, MG, Sawan, C., Wang, ZQ and Herceg, Z. (2006) Epigenetic information in chromatin: The code of entry for DNA repair. Cell Cycle, 5, pp. 696-701.
18. Chiang, PK, Gordon, RK and Tal, J. (1996) S-Adenosylmethionine and methylation. FASEB J, 10, pp. 471-480.
19. Jaenisch, R. and Bird, A. (2003) Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals. Nat Genet, 33, pp. 245-254.
20. Bird, AP. (1986) CpG-rich islands and the function of DNA methylation. Nature, 321, pp. 209-213.
21. Bird, AP and Wolffe, AP. (1999) Methylation-induced repression: Belts, braces, and chromatin. Cell, 99, pp. 451-454.
22. Gruenbaum, Y., Cedar, H. and Razin, A. (1982) Substrate and sequence specificity of a eukaryotic DNA methylase. Nature, 295, pp. 620-622.
23. Bestor, TH. (1988) Cloning of a mammalian DNA methyltransferase. Gene, 74, pp. 9-12.
24. Okano, M., Bell, DW, Haber, DA and Li, E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, pp. 247-257.
25. Li, E., Bestor, TH and Jaenisch, R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, pp. 915-926.
26. Lei, H., Oh, SP and Okano, M. (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development, 122, pp. 3195-3205.
27. Veyver, IB. Van den (2002) Genetic effects of methylation diets. Annu Rev Nutr, 22, pp. 255-282.
28. Reik, W., Dean, W. and Walter, J. (2001) Epigenetic reprogramming in mammalian development. Science, 293, pp. 1089-1093.
29. Waterland, RA and Garza, C. (1999) Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr, 69, pp. 179-197.
30. Waterland, RA, Lin, JR, Smith, CA and Jirtle, RL. (2006) Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus. Hum Mol Genet, 15, pp. 705-716.
31. Doherty, AS, Mann, MR, Tremblay, KD, Bartolomei, MS and Schultz, RM. (2000) Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod, 62, pp. 1526-1535.
32. Orstavik, KH, Eiklid, K. and van der Hagen, CB (2003) Another case of imprinting defect in a girl with Angelman syndrome who was conceived by intracytoplasmic semen injection. Am J Hum Genet, 72, pp. 218-219.
33. DeBaun, MR, Niemitz, EL and Feinberg, AP. (2003) Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19. Am J Hum Genet, 72, pp. 156-160.
34. Thompson, SL, Konfortova, G., Gregory, RI, Reik, W., Dean, W. and Feil, R. (2001) Environmental effects on genomic imprinting in mammals. Toxicol Lett, 120, pp. 143-150.
35. Ke, X., Lei, Q. and James, SJ (2006) Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats. Physiol Genomics, 25, pp. 16-28.
36. MacLennan, NK, James, SJ and Melnyk, S. (2004) Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics, 18, pp. 43-50.
37. Pham, TD, MacLennan, NK, Chiu, CT, Laksana, GS, Hsu, JL and Lane, RH. (2003) Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol, 285, p. R962.
38. Susser, ES and Lin, SP. (1992) Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944-1945. Arch Gen Psychiatry, 49, pp. 983-988.
39. Susser, E., Neugebauer, R. and Hoek, HW (1996) Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry, 53, pp. 25-31.
40. Hoek, HW, Brown, AS and Susser, E. (1998) The Dutch famine and schizophrenia spectrum disorders. Soc Psychiatry Psychiatr Epidemiol, 33, pp. 373-379.
41. Hoek, HW, Susser, E., Buck, KA, Lumey, LH, Lin, SP and Gorman, JM. (1996) Schizoid personality disorder after prenatal exposure to famine. Am J Psychiatry, 153, pp. 1637-1639.
42. Susser, E., Hoek, HW and Brown, A. (1998) Neurodevelopmental disorders after prenatal famine: The story of the Dutch Famine Study. Am J Epidemiol, 147, pp. 213-216.
43. Clair, D. St., Xu, M. and Wang, P. (2005) Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA, 294, pp. 557-562.
44. Lackland, DT, Egan, BM and Ferguson, PL. (2003) Low birth weight as a risk factor for hypertension. J Clin Hypertens (Greenwich), 5, pp. 133-136.
45. Kyle, UG and Pichard, C. (2006) The Dutch Famine of 1944-1945: A pathophysiological model of long-term consequences of wasting disease. Curr Opin Clin Nutr Metab Care, 9, pp. 388-394.
46. Barker, DJ. (1992) The fetal origins of adult hypertension. J Hypertens Suppl, 10, p. S39.
47. Barker, DJ. (1992) Fetal growth and adult disease. Br J Obstet Gynaecol, 99, pp. 275-276.
48. Szyf, M., Weaver, IC, Champagne, FA, Diorio, J. and Meaney, MJ. (2005) Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Front Neuroendocrinol, 26, pp. 139-162.
49. Weaver, IC, Cervoni, N. and Champagne, FA (2004) Epigenetic programming by maternal behavior. Nat Neurosci, 7, pp. 847-854.
50. Lefebvre, L., Viville, S., Barton, SC, Ishino, F. and Surani, MA. (1997) Genomic structure and parent-of-origin-specific methylation of Peg1. Hum Mol Genet, 6, pp. 1907-1915.
51. Kaneko-Ishino, T., Kuroiwa, Y. and Miyoshi, N. (1995) Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Nat Genet, 11, pp. 52-59.
52. Lefebvre, L., Viville, S., Barton, SC, Ishino, F., Keverne, EB and Surani, MA. (1998) Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nat Genet, 20, pp. 163-169.
53. Xu, GL, Bestor, TH and Bourc'his, D. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature, 402, pp. 187-191.
54. Ehrlich, M., Buchanan, KL and Tsien, F. (2001) DNA methyltransferase 3B mutations linked to the ICF syndrome cause dysregulation of lymphogenesis genes. Hum Mol Genet, 10, pp. 2917-2931.
55. Bienvenu, T. and Chelly, J. (2006) Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized. Nat Rev Genet, 7, pp. 415-426.
56. Rakyan, VK, Blewitt, ME, Druker, R., Preis, JI and Whitelaw, E. (2002) Metastable epialleles in mammals. Trends Genet, 18, pp. 348-351.
57. Whitelaw, E. and Martin, DI. (2001) Retrotransposons as epigenetic mediators of phenotypic variation in mammals. Nat Genet, 27, pp. 361-365.
58. Waterland, RA and Jirtle, RL. (2003) Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol, 23, pp. 5293-5300.
59. Yoder, JA, Walsh, CP and Bestor, TH. (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet, 13, pp. 335-340.
60. Fraga, MF, Ballestar, E. and Paz, MF (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA, 102, pp. 10 604-10 609.
61. Stine, OC, Xu, J. and Koskela, R. (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet, 57, pp. 1384-1394.
62. McMahon, FJ, Stine, OC, Meyers, DA, Simpson, SG and DePaulo, JR. (1995) Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet, 56, pp. 1277-1286.
63. Grigoroiu-Serbanescu, M. and Nothen, M. (1995) Clinical evidence for genomic imprinting in bipolar I disorder. Acta Psychiatr Scand, 92, pp. 365-370.
64. Kato, T., Winokur, G., Coryell, W., Keller, MB, Endicott, J. and Rice, J. (1996) Parent-of-origin effect in transmission of bipolar disorder. Am J Med Genet, 67, pp. 546-550.
65. Gershon, ES, Badner, JA, Detera-Wadleigh, SD, Ferraro, TN and Berrettini, WH. (1996) Maternal inheritance and chromosome 18 allele sharing in unilineal bipolar illness pedigrees. Am J Med Genet, 67, pp. 202-207.
66. Angst, J., Gamma, A., Gastpar, M., Lepine, JP, Mendlewicz, J. and Tylee, A. (2002) Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies. Eur Arch Psychiatry Clin Neurosci, 252, pp. 201-209.
67. Hafner, H., Riecher-Rossler, A., Maurer, K., Fatkenheuer, B. and Loffler, W. (1992) First onset and early symptomatology of schizophrenia. A chapter of epidemiological and neurobiological research into age and sex differences. Eur Arch Psychiatry Clin Neurosci, 242, pp. 109-118.
68. Osran, H., Reist, C., Chen, CC, Lifrak, ET, Chicz-DeMet, A. and Parker, LN. (1993) Adrenal androgens and cortisol in major depression. Am J Psychiatry, 150, pp. 806-809.
69. Ozcan, ME and Banoglu, R. (2003) Gonadal hormones in schizophrenia and mood disorders. Eur Arch Psychiatry Clin Neurosci, 253, pp. 193-196.
70. Saluz, HP, Jiricny, J. and Jost, JP. (1986) Genomic sequencing reveals a positive correlation between the kinetics of strand-specific DNA demethylation of the overlapping estradiol/glucocorticoid-receptor binding sites and the rate of avian vitellogenin mRNA synthesis. Proc Natl Acad Sci USA, 83, pp. 7167-7171.
71. Truss, M., Chalepakis, G. and Pina, B. (1992) Transcriptional control by steroid hormones. J Steroid Biochem Mol Biol, 41, pp. 241-248.
72. Yokomori, N., Moore, R. and Negishi, M. (1995) Sexually dimorphic DNA demethylation in the promoter of the Slp (sex-limited protein) gene in mouse liver. Proc Natl Acad Sci USA, 92, pp. 1302-1306.
73. Griffon, N., Crocq, MA and Pilon, C. (1996) Dopamine D3 receptor gene: organization, transcript variants, and polymorphism associated with schizophrenia. Am J Med Genet, 67, pp. 63-70.
74. Asherson, P., Mant, R. and Holmans, P. (1996) Linkage, association and mutational analysis of the dopamine D3 receptor gene in schizophrenia. Mol Psychiatry, 1, pp. 125-132.
75. Williams, J., Spurlock, G. and Holmans, P. (1998) A meta-analysis and transmission disequilibrium study of association between the dopamine D3 receptor gene and schizophrenia. Mol Psychiatry, 3, pp. 141-149.
76. Petronis, A. (2000) The genes for major psychosis: Aberrant sequence or regulation?. Neuropsychopharmacology, 23, pp. 1-12.
77. Nestoros, JN, Ban, TA and Lehmann, HE. (1977) Transmethylation hypothesis of schizophrenia: Methionine and nicotinic acid. Int Pharmacopsychiatry, 12, pp. 215-246.
78. Cohen, BM, Lipinski, JF, Vuckovic, A. and Prosser, E. (1982) Blood S-adenosyl-L-methionine levels in psychiatric disorders. Am J Psychiatry, 139, pp. 229-231.
79. Alonso-Aperte, E., Ubeda, N., Achon, M., Perez-Miguelsanz, J. and Varela-Moreiras, G. (1999) Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation. Neurology, 52, pp. 750-756.
80. Detich, N., Bovenzi, V. and Szyf, M. (2003) Valproate induces replication-independent active DNA demethylation. J Biol Chem, 278, pp. 27 586-27 592.
81. Abdolmaleky, HM, Smith, CL and Faraone, SV (2004) Methylomics in psychiatry: Modulation of gene-environment interactions may be through DNA methylation. Am J Med Genet B Neuropsychiatr Genet, 127, pp. 51-59.
82. Fink, A., Hays, RD, Moore, AA and Beck, JC. (1996) Alcohol-related problems in older persons. Determinants, consequences, and screening. Arch Intern Med, 156, pp. 1150-1156.
83. Whelan, G. (1995) Alcohol-related health problems in the elderly. Med J Aust, 162, pp. 325-327.
84. Maier, SE, Cramer, JA, West, JR and Sohrabji, F. (1999) Alcohol exposure during the first two trimesters equivalent alters granule cell number and neurotrophin expression in the developing rat olfactory bulb. J Neurobiol, 41, pp. 414-423.
85. Duman, RS and Monteggia, LM. (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry, 59, pp. 1116-1127.
86. Frey, BN, Andreazza, AC and Cereser, KM (2006) Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania. Life Sci, 79, pp. 281-286.
87. Lee, MG, Wynder, C., Schmidt, DM, McCafferty, DG and Shiekhattar, R. (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol, 13, pp. 563-567.
88. Shi, Y., Lan, F. and Matson, C. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell, 119, pp. 941-953.
89. Kato, MV, Shimizu, T., Nagayoshi, M., Kaneko, A., Sasaki, MS and Ikawa, Y. (1996) Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Am J Hum Genet, 59, pp. 1084-1090.
90. Kato, MV, Ikawa, Y., Hayashizaki, Y. and Shibata, H. (1998) Paternal imprinting of mouse serotonin receptor 2A gene Htr2 in embryonic eye: A conserved imprinting regulation on the RB/Rb locus. Genomics, 47, pp. 146-148.
91. Bunzel, R., Blumcke, I. and Cichon, S. (1998) Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain. Brain Res Mol Brain Res, 59, pp. 90-92.
92. Polesskaya, OO and Sokolov, BP. (2002) Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res, 67, pp. 812-822.
93. Bray, NJ, Buckland, PR, Hall, H., Owen, MJ and O'Donovan, MC. (2004) The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Mol Psychiatry, 9, pp. 109-114.
94. Fatemi, SH. (2001) Reelin mutations in mouse and man: From reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Mol Psychiatry, 6, pp. 129-133.
95. Grayson, DR, Jia, X. and Chen, Y. (2005) Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci USA, 102, pp. 9341-9346.
96. Abdolmaleky, HM, Thiagalingam, S. and Wilcox, M. (2005) Genetics and epigenetics in major psychiatric disorders: Dilemmas, achievements, applications, and future scope. Am J Pharmacogenomics, 5, pp. 149-160.
97. Abdolmaleky, HM, Cheng, KH and Russo, A. (2005) Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: A preliminary report. Am J Med Genet B Neuropsychiatr Genet, 134, pp. 60-66.
98. Sengupta, N. and Seto, E. (2004) Regulation of histone deacetylase activities. J Cell Biochem, 93, pp. 57-67.
99. Baylin, SB. (2005) DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol, 2, p. S4.
100. Szyf, M., Pakneshan, P. and Rabbani, SA. (2004) DNA methylation and breast cancer. Biochem Pharmacol, 68, pp. 1187-1197.
101. Egger, G., Liang, G., Aparicio, A. and Jones, PA. (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature, 429, pp. 457-463.
102. Himmelhoch, JM, Fuchs, CZ and Symons, BJ. (1982) A double-blind study of tranylcypromine treatment of major anergic depression. J Nerv Ment Dis, 170, pp. 628-634.
103. Himmelhoch, JM, Thase, ME, Mallinger, AG and Houck, P. (1991) Tranylcypromine versus imipramine in anergic bipolar depression. Am J Psychiatry, 148, pp. 910-916.