The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain

Molecular Psychiatry

Volumn 9, Issue 1, 2004, Pages 109-114

  Bray, N J ^a   Buckland, P R ^a   Hall, H ^b   Owen, M J ^a   O'Donovan, M C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

5HT2A; Epigenetic; Expression; HTR2A; Polymorphism

Indexed keywords

GENOMIC DNA; MESSENGER RNA; SEROTONIN 2A RECEPTOR;

ACCURACY; ADULT; AGED; ARTICLE; BRAIN; FEMALE; GENE EXPRESSION; GENETIC PROCEDURES; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; MALE; POLYMORPHIC LOCUS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BRAIN CHEMISTRY; EPIGENESIS, GENETIC; GENE EXPRESSION; GENOTYPE; HUMANS; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT2A; RNA, MESSENGER;

EID: 0842286644     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001366     Document Type: Article

References (25)

1. Meltzer HY. The role of serotonin in antipsychotic drug action. Neuropsychopharmacology 1999; 21: 106S-115S.
2. Aghajanian GK, Marek GJ. Serotonin and hallucinogens. Neuropsychopharmacology 1999; 21: 16S-23S.
3. Hrdina PD, Bakish D, Ravindran A, Chudzik J, Cavazzoni P, Lapierre YD. Platelet serotonergic indices in major depression: upregulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry Res 1997; 66: 73-85.
4. Burnet PW, Eastwood SL, Harrison PJ. 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology 1996; 15: 442-455.
5. Inayama Y, Yoneda H, Sakai T, Ishida T, Nonomura Y, Kono Y et al. Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. Am J Med Genet 1996; 67: 103-105.
6. Williams J, McGuffin P, Nothen M, Owen MJ. Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia. EMASS Collaborative Group. European Multicentre Association Study of Schizophrenia. Lancet 1997; 349: 1221.
7. Arranz MJ, Munro J, Sham P, Kirov G, Murray RM, Collier DA et al. Meta-analysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res 1998; 32: 93-99.
8. Holmes C, Arranz MJ, Powell JF, Collier DA, Lovestone S. 5-HT2A and 5-HT2C receptor polymorphisms and psychopathology in late onset Alzheimer's disease. Hum Mol Genet 1998; 7: 1507-1509.
9. Arias B, Gutierrez B, Pintor L, Gasto C, Fananas L. Variability in the 5-HT(2A) receptor gene is associated with seasonal pattern in major depression, Mol Psychiatry 2001; 6: 239-242.
10. O'Donovan MC, Owen MJ. Candidate-gene association studies of schizophrenia. Am J Hum Genet 1999; 65: 587-592.
11. Polesskaya OO, Sokolov BP. Differential expression of the 'C' and 'T' alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J Neurosci Res 2002; 67: 812-822.
12. Spurlock G, Heils A, Holmans P, Williams J, D'Souza UM, Cardno A et al. A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter. Mol Psychiatry 1998; 3: 42-49.
13. Norton N, Williams NM, Williams HJ, Spurlock G, Kirov G, Morris DW et al. Universal, robust, highly quantitative SNP allele frequency measurement in DNA pools. Hum Genet 2002;110: 471-478.
14. Singer-Sam J, Chapman V, LeBon JM, Riggs AD. Parental imprinting studied by allele-specific primer extension after PCR: paternal X chromosome-linked genes are transcribed prior to preferential paternal X chromosome inactivation. Proc Natl Acad Sci USA 1992; 89: 10469-10473.
15. Le Hellard S, Ballereau SJ, Visscher PM, Torrance HS, Pinson J, Morris SW et al. SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res 2002; 30: 74.
16. Yan H, Yuan W, Velculescu VE, Vogelstein B, Kinzler KW. Allelic variation in human gene expression. Science 2002; 297: 1143.
17. Bray NJ, Buckland PR, Owen MJ, O'Donovan MC. Cis-acting variation in the expression of a high proportion of genes in human brain. Hum Genet 2003; 113: 149-153.
18. Hoogendoorn B, Norton N, Kirov G, Williams N, Hamshere ML, Spurlock G et al. Cheap, accurate and rapid allele frequency estimation of single nucleotide polymorphisms by primer extension and DHPLC in DNA pools. Hum Genet 2000; 107: 488-493.
19. Breen G, Harold D, Ralston S, Shaw D, St Clair D. Determining SNP allele frequencies in DNA pools. Biotechniques 2000; 28: 464-466, 468, 470.
20. Turecki G, Briere R, Dewar K, Antonetti T, Lesage AD, Segwin M et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. Am J Psychiatry 1999; 156: 1456-1458.
21. Kouzmenko AP, Hayes WL, Pereira AM, Dean B, Burnet PW, Harrison PJ. 5-HT2A receptor polymorphism and steady state receptor expression in schizophrenia. Lancet 1997; 349: 1815.
22. Kouzmenko AP, Scaffidi A, Pereira AM, Hayes WL, Copolov DL, Dean B. No correlation between A(-1438)G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia. Hum Hered 1999; 49: 103-105.
23. Kato MV, Shimizu T, Nagayoshi M, Kaneko A, Sasaki MS, Ikawa Y. Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. Am J Hum Genet 1996; 59: 1084-1090.
24. Bunzel R, Blumcke I, Cichon S, Normann S, Schramm J et al. Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain. Brain Res Mol Brain Res 1998; 59: 90-92.
25. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002; 30: 233-237.