A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 1, 2008, Pages 174-179

  Lin, Xiaoyu ^a   David, Caroline A ^a   Donnelly, Jennifer B ^a   Michaelides, Mike ^a   Chandel, Navdeep S ^b   Huang, Xiaoli ^a   Warrior, Usha ^a   Weinberg, Frank ^b   Tormos, Kathryn V ^b   Fesik, Stephen W ^a   Shen, Yu ^a  

^a ABBOTT LABORATORIES   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Hypoxia; Hypoxia inducible factor; Reactive oxygen species; RNAi; siRNA

Indexed keywords

ACETIC ACID DERIVATIVE; HYPOXIA INDUCIBLE FACTOR 1; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; GENOME; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; SCREENING;

ACETATES; ANOXIA; CHEMISTRY, PHARMACEUTICAL; GENE LIBRARY; GENOMICS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MITOCHONDRIA; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; PHARMACOGENETICS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SMALL MOLECULE LIBRARIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 38349160160     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0706585104     Document Type: Article

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