Mechanisms of epithelial-mesenchymal transition of peritoneal mesothelial cells during peritoneal dialysis

Journal of Korean Medical Science

Volumn 22, Issue 6, 2007, Pages 943-945

  Hi, Bahl Lee ^a   Ha, Hunjoo ^b  

^a Soonchunhyang University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Bone morphogenetic protein 7; Fibrosis; Mitogen activated protein kinases; Peritoneal dialysis; Reactive oxygen species

Indexed keywords

EPITHELIUM CELL; FIBROSIS; HUMAN; MESODERM; PATHOLOGY; PERITONEAL DIALYSIS; PERITONEUM; REVIEW;

EPITHELIAL CELLS; FIBROSIS; HUMANS; MESODERM; PERITONEAL DIALYSIS; PERITONEUM;

EID: 38349155755     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2007.22.6.943     Document Type: Review

References (25)

1. Williams JD, Craig KJ, Topley N, von Ruhland C, Fallon M, Newman GR, Mackenzie RK, William GT, Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol 2002; 13: 470-9.
2. Davies SJ, Phillips L, Naish PF, Russell GI. Peritoneal glucose exposure and changes in membrane solute transport with time on peritoneal dialysis. J Am Soc Nephrol 2001; 12: 1046-51.
3. Eddy AA. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996; 7: 2495-508.
4. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001; 159: 1465-75.
5. Iwano M, Plieth D, Danoff TM, Xue C, Okada H, Neilson EG. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 2002; 110: 341-50.
6. Lan HY. Tubular epithelial-myofibroblast transdifferentiation mechanism in proximal tubule cells. Curr Opin Nephrol Hypertens 2003; 12: 25-9.
7. Yanez-Mo M, Lara-Pezzi E, Selgas R, Ramirez-Huesca M, Dominguez-Jimenez C, Jimenez-Heffernan JA, Aguilera A, Sanchez-Tomero JA, Bajo MA, Alvarez V, Castro MA, del Peso G, Cirujeda A, Gamallo C, Sanchez-Madrid F, Lopez-Cabrera M. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Eng J Med 2003; 348: 403-13.
8. Margetts PJ, Bonniaud P, Liu L, Hoff CM, Holmes CJ, West-Mays JA, Kelly MM. Transient overexpression of TGF-β1 induces epithelial mesenchymal transition in the rodent peritoneum. J Am Soc Nephrol 2005; 16: 425-36.
9. Aroeira LS, Aguilera A, Selgas R, Ramirez-Huesca M, Perez-Lozano ML, Cirugeda A, Bajo MA, del Peso G, Sanchez-Tomero JA, Jimenez-Heffernan JA, Lopez-Cabrera M. Mesenchymal conversion of mesothelial cells as a mechanism responsible for high solute transport rate in peritoneal dialysis: role of vascular endothelial growth factor. Am J Kidney Dis 2005; 46: 938-48.
10. Lee HB, Yu MR, Song JS, Ha H. Reactive oxygen species amplify protein kinase C signaling in high glucose-induced fibronectin expression by human peritoneal mesothelial cells. Kidney Int 2004; 65: 1170-9.
11. Ha H, Song JS, Yu MR, Lee HB. Oxidative stress in peritoneal dialysis. Lecture Notes ICB Semin 2004; 65: 32-9.
12. Noh H, Kim JS, Han KH, Lee GT, Song JS, Chung SH, Jeon JS, Ha H, Lee HB. Oxidative stress during peritoneal dialysis: Implications in functional and structural changes in the membrane. Kidney Int 2006; 69: 2022-8.
13. Lee HB, Song JS, Ha H. Mechanisms of epithelial mesenchymal transition in human peritoneal mesothelial cells. Korean J Nephrol 2006; 25 (Suppl 1): S97.
14. Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, Lee HB. Role of reactive oxygen species in TGF-β1-induced MAPK activation and epithelial- mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005; 16: 667-75.
15. Do JY, Kim YL, Park JW, Cho KH, Kim TW, Yoon KW, Kim CD, Park SH, Han JH, Song IH. The effect of low glucose degradation product dialysis solution on epithelial-to-mesenchymal transition in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 2005; 25 (Suppl 3): S22-5.
16. Che W, Asahi M, Takahashi M, Kaneto H, Okado A, Higashiyama S, Taniguchi N. Selective induction of heparin-binding epidermal growth factor-like growth factor by methylglyoxal and 3-deoxyglucosone in rat aortic smooth muscle cells. The involvement of reactive oxygen species formation and a possible implication for atherogenesis in diabetes. J Biol Chem 1997; 272: 18453-9.
17. Aguilera A, Aroeira LS, Parmirez-Huesca M, Perez-Lozano ML, Cirugeda A, Bajo MA, Del Peso G, Valenzuela-Fernandez A, Sanchez-Tomero JA, Lopez-Cabrera M, Selgas R. Effects of rapamycin on the epithelial-to-mesenchymal transition of human peritoneal mesothelial cells. Int J Art Organs 2005; 28: 164-9.
18. Nagai K, Matsubara T, Mima A, Sumi E, Kanamori H, Iehara N, Fukatsu A, Yanagita M, Nakano T, Ishimoto Y, Kita T, Doi T, Arai H. Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. Kidney Int 2005; 68: 552-61.
19. Komers R, Lindsley JN, Anderson S. Renal cortical expression of Akt kinase is increased in Zuker diabetic fatty rats and controls mTOR phosphorylation. J Am Soc Nephrol 2004; 15: SU-PO890 (abstract).
20. Lloberas N, Cruzado JM, Franquesa M, Herrero-Fresneda I, Torras J, Alperovich G, Rama I, Vidal A, Grinyo JM. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 2006; 17: 1395-404.
21. Hruska KA, Guo G, Wozniak M, Martin D, Miller S, Liapis H, Loveday K, Klahr S, Sampath TK, Morrissey J. Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction. Am J Physiol Renal Physiol 2000; 279: F130-43.
22. Wang S, Chen Q, Simon TC, Strebeck F, Chaudhary L, Morrissey J, Liapis H, Klahr S, Hruska KA. Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 2003; 63: 2037-49.
23. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-tomesenchymal transition and reverses chronic renal injury. Nat Med 2003; 9: 964-8.
24. Seo JY, Ha H, Yu MR, Kim JR, Ahn MW, Lee HB. Antifibrotic effect of BMP-7 in the peritoneum and the mechanism. Korean J Nephrol 2007; 26: 33-42.
25. Vargha R, Endemann M, Kratochwill K, Riesenhuber A, Wick N, Krachler AM, Malaga-Dieguerz L, Aufricht C. Ex vivo reversal of in vivo transdifferentiation in mesothelial cells grown from peritoneal dialysate effluents. Nephrol Dial Transplant 2006; 21: 2943-7.