Nanoconjugate based on polymalic acid for tumor targeting

Chemico-Biological Interactions

Volumn 171, Issue 2, 2008, Pages 195-203

  Ljubimova, Julia Y ^a,b   Fujita, Manabu ^a   Khazenzon, Natalya M ^a   Lee, Bong Seop ^a   Wachsmann Hogiu, Sebastian ^a   Farkas, Daniel L ^a   Black, Keith L ^a,b   Holler, Eggehard ^b,c  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b Arrogene Inc   (United States)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Brain glioma; Breast cancer; Drug delivery system; EPR effect; Fluorescence imaging; Poly(malic acid)

Indexed keywords

MALEIMIDE; MALIC ACID DERIVATIVE; POLYCEFIN; POLYMALIC ACID; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CANCER; BREAST CANCER; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; ENDOCYTOSIS; ENZYMATIC DEGRADATION; FLUORESCENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; ILLUMINATION; IN VIVO STUDY; KIDNEY; LIVER; MICROSCOPY; MOUSE; NONHUMAN; NUDE MOUSE; PHYSARUM POLYCEPHALUM; SIGNAL DETECTION;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; FLUORESCENCE; HUMANS; MALATES; MICE; MICE, NUDE; NANOPARTICLES; POLYMERS;

ANIMALIA; MUS MUSCULUS; PHYSARUM POLYCEPHALUM;

EID: 38349148359     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.01.015     Document Type: Article

References (43)

1. Lee B.S., Vert M., and Holler E. Water-soluble aliphatic polyesters; poly(malic acid)s. In: Doi Y., and Steinbüchel A. (Eds). Biopolymers, vol. 3a: Polyesters (2002), Wiley-VCH, Weinheim 75-103
2. Lee B.S., Fujita M., Khazenon N.M., Wawrowsky K.A., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Ljubimova J.Y., and Holler E. Polycefin, a new prototype of multifunctional nanoconjugate based on poly(β-l-malic acid) for drug delivery. Bioconjugate Chem. 17 (2006) 317-326
3. Ljubimova J.Y., Fugita M., Khazenzon N.M., Das A., Pikul B.B., Newman D., Sekiguchi K., Sorokin L.M., Sasaki T., and Black K.L. Laminin-8 association with glial tumor grade, recurrence and patient survival. Cancer 101 (2004) 604-612
4. Fujita M., Khazenzon N.M., Bose S., Sekiguchi K., Sasaki T., Carter W.G., Ljubimov A.V., Black K.L., and Ljubimova J.Y. Overexpression of β1 chain-containing laminins in capillary basement membranes of human breast cancer and its metastases. Breast Cancer Res. 7 (2005) 411-421
5. Ljubimova J.Y., Fujita M., Khazenzon N.M., Ljubimov A.V., and Black K.L. Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. Front. Biosci. 11 (2006) 81-88
6. Khazenzon N.M., Ljubimov A.V., Lakhter A.J., Fujiwara H., Sekiguchi K., Sorokin L.M., Virtanen I., Black K.L., and Ljubimova J.Y. Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro. Mol. Cancer Ther. 2 (2003) 985-994
7. Daniel J.W., and Baldwin H.H. Methods of culture for plasmodial myxomycetes. In: Prescott D.A. (Ed). Methods in Cell Physiology (1964), Academic Press, New York, NY 9-41
8. Fischer H., Erdmann S., and Holler E. An unusual polyanion from Physarum polycephalum that inhibits homologous DNA polymerase-α in vitro. Biochemistry 28 (1989) 5219-5226
9. Cammas S., Guerin Ph., Girault J.P., Holler E., Gache Y., and Vert M. Natural poly(l-malic acid): NMR shows a poly(3-hydroxy acid)-type structure. Macromolecules 28 (1993) 4681-4684
10. Fernandez C.E., Mancera M., Holler E., Bou J.J., Galbis J.A., and Munoz-Guerra S. Low molecular weight poly(alpha-methyl-beta-l-malate) of microbial origin: synthesis and crystallization. Macromol. Biosci. 5 (2005) 172-176
11. Portilla J.A., Garcia-Alvarez M., de Ilarduya A.M., Holler E., and Munoz-Guerra S. Nanostructural complexes of poly(beta-l-malate) and cationic surfactants: synthesis, characterization and structural aspects. Biomacromolecules 7 (2006) 161-170
12. Lee B.-S., Vert M., and Holler E. Water-soluble aliphatic polyesters: poly(malic acid)s. In: Doi Y., and Steinbüchel A. (Eds). Biopolymers (2002), Wiley-VCH, Weinheim 75-103
13. Farkas D.L. Invention and commercialization in optical bioimaging. Nat. Biotechnol. 21 (2003) 1269-1271
14. Fujita M., Khazenzon N.M., Ljubimov A.V., Lee B.S., Virtanen I., Holler E., Black K.L., and Ljubimova J.Y. Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis. Angiogenesis 9 (2006) 183-191
15. Sasatsu M., Onishi H., and Machida Y. In vitro and in vivo characterization of nanoparticles made of MeO-PEG amine/PLA block copolymer and PLA. Int. J. Pharm. 317 (2006) 167-174
16. Duan Y., Sun X., Gong T., Wang Q., and Zhang Z. Preparation of DHQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviours in vitro/in vivo. J. Mater. Sci. Mater. Med. 17 (2006) 509-516
17. Heyes J., Hall K., Tailor V., Lenz R., and MacLachlan I. Synthesis and characterization of novel poly(ethylene glycol)-lipid conjugates suitable for use in drug delivery. J. Control. Release 112 (2006) 280-290
18. Ahmed F., Pakunlu R.I., Brannan A., Bates F., Minko T., and Discher D.E. Biodegradable polymerosomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116 (2006) 150-158
19. Koziara J.M., Whisman T.R., Tseng M.T., and Mumper R.J. In vivo efficacy of novel paclitaxel nanoparticles in paclitaxel-resistant human colorectal tumors. J. Control. Release 112 (2006) 312-319
20. Chytil P., Etrych T., Konak C., Sirova M., Mrkvan T., Rihova B., and Ulbrich K. Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification. J. Control. Release 115 (2006) 26-36
21. Satchi-Fainaro R., Puder M., Davies J.W., Tran H.T., Sampson D.A., Greene A.K., Corfas G., and Folkman J. Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470. Nat. Med. 10 (2004) 255-261
22. Saul J.M., Annapragada A.V., and Bellamkonda R.V. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. J. Control. Release 114 (2006) 277-287
23. Leamon C.P., Reddy J.A., Vlahov I.R., Kleindl P.J., Vetzel M., and Westrick E. Synthesis and biological evaluation of EC140: a novel folate-targeted Vinca alkaloid conjugate. Bioconjugate Chem. 17 (2006) 1226-1232
24. Chiu S.J., Liu S., Perrotti D., Marcucci G., and Lee R.J. Efficient delivery of a Bcl-2-specific antisense oligodeoxyribonucleotide (G3139) via transferrin receptor-targeted liposomes. J. Control. Release 112 (2006) 199-207
25. Pun S.H., Tack F., Bellocq N.C., Cheng J., Grubbs B.H., Jensen G.S., Davis M.E., Brewster M., Janicot M., Janssens B., Floren W., and Bakker A. Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol. Ther. 3 (2004) 641-650
26. Shao K., Hou Q., Go M.L., Wong K.P., and Li Q.-T. Intracellular drug delivery by sulfatide-mediated liposomes to gliomas. J. Control. Release 115 (2006) 150-157
27. Farokhzad O.C., Cheng J., Teply B.A., Sherifi I., Ion S., Kantoff P.W., Richie J.P., and Langer R. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 6315-6320
28. Longmuir K.J., Robertson R.T., Haynes S.M., Baratta J.L., and Waring A.J. Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of Plasmodium amino acid sequence. Pharm. Res. 23 (2006) 759-769
29. Weissleder R., Kelly K., Sun E.Y., Shtatland T., and Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat. Biotechnol. 23 (2005) 1418-1423
30. Costantino L., Gandolfi F., Tosi G., Rivasi F., Vandelli M.A., and Forni F. Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier. J. Control. Release 108 (2005) 84-96
31. Montet X., Weissleder R., and Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjugate Chem. 17 (2006) 905-911
32. 3 expression. Bioconjugate Chem. 17 (2006) 1069-1076
33. Banciu M., Schiffelers R.M., Fens M.H.A.M., Metselaar J.M., and Storm G. Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice. J. Control. Release 113 (2006) 1-8
34. Pakunlu R.I., Wang Y., Saad M., Khandare J.J., Starovoytov V., and Minko T. In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug. J. Control. Release 114 (2006) 153-162
35. Torchilin V.P., and Lukyanov A.N. Peptide and protein drug delivery to and into tumors: challenges and solutions. Drug Discov. Today 8 (2003) 259-266
36. Kloeckner J., Boeckle S., Persson D., Roedl W., Ogris M., Berg K., and Wagner E. DNA polyplexes based on degradable oligoethylenimine-derivatives: combination with EGF receptor targeting and endosomal release functions. J. Control. Release 116 (2006) 115-122
37. McNamara II J.O., Andrechek E.R., Wang Y., Viles K.D., Rempel R.E., Gilboa E., Sullenger B.A., and Giangrande P.H. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat. Biotechnol. 24 (2006) 1005-1014
38. Dancey J.E., and Chen H.X. Strategies for optimizing combinations of molecular targeted anticancer agents. Nat. Rev. Drug Discov. 5 (2006) 649-659
39. Fournié P., Domurado D., Guérin P., Braud C., Vert M., and Madelmont J.-C. In vivo fate of end-chain radiolabelled poly(β-malic acid), a water soluble biodegradable drug carrier. J. Bioact. Compat. Polym. 5 (1990) 381-395
40. Fournié P., Domurado D., Guérin P., Braud C., Vert M., and Pontikis R. In vivo fate of repeat-unit-radiolabelled poly(β-malic acid), a potential drug carrier. J. Bioact. Compat. Polym. 7 (1992) 113-129
41. Domurado D., Fournié P., Braud C., Vert M., Guérin P., and Simonnet F. In vivo fates of degradable poly(β-malic acid) and of its precursor, malic acid. J. Bioact. Compat. Polym. 18 (2003) 23-32
42. Seymour L.W., Miyamoto Y., Maeda H., Brereton M., Strohalm J., Ulbrich K.U., and Duncan R. Influence of molecular weight on passive tumor accumulation of a soluble macromolecular drug carrier. Eur. J. Cancer 31A (1995) 766-777
43. Ramakrishnan S., and Houston L.L. Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide-linked pokeweed antivirial protein-antibody conjugates from blood. Cancer Res. 45 (1985) 2031-2036