Elevated fatty acid ethyl esters in meconium of sheep fetuses exposed in utero to ethanol - A new animal model

Pediatric Research

Volumn 63, Issue 2, 2008, Pages 164-168

  Littner, Yoav ^a   Cudd, Timothy A ^b   O'Riordan, Mary A ^a   Cwik, Andrew ^a   Bearer, Cynthia F ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ARACHIDONIC ACID ETHYL ESTER; FATTY ACID ESTER; LINOLEIC ACID ETHYL ESTER; OLEIC ACID ETHYL ESTER; PALMITIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; MECONIUM; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ANIMALS; AREA UNDER CURVE; DISEASE MODELS, ANIMAL; ESTERS; ETHANOL; FATTY ACIDS; FEMALE; FETAL ALCOHOL SYNDROME; MATERNAL EXPOSURE; MECONIUM; OLEIC ACIDS; PREGNANCY; PREGNANCY, ANIMAL; SHEEP; SHEEP, DOMESTIC;

EID: 38349120792     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/PDR.0b013e31815f651e     Document Type: Article

References (34)

1. Abel EL, Sokol RJ 1991 A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol Clin Exp Res 15:514-524
2. Sampson PD, Streissguth AP, Bookstein FL, Little RE, Clarren SK, Dehaene P, Hanson JW, Graham JM 1997 Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology 56:317-326
3. Little BB, Snell LM, Rosenfeld CR, Gilstrap LC 3rd, Gant NF 1990 Failure to recognize fetal alcohol syndrome in newborn infants. Am J Dis Child 144:1142-1146
4. Streissguth AP, Bookstein FL, Barr HM, Sampson PD, O'Malley K, Young JK 2004 Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects. J Dev Behav Pediatr 25:228-238
5. Russell M, Martier SS, Sokol RJ, Mudar P, Jacobson S, Jacobson J 1996 Detecting risk drinking during pregnancy: a comparison of four screening questionnaires. Am J Public Health 86:1435-1439
6. Stoler JM, Huntington KS, Peterson CM, Peterson KP, Daniel P, Aboagye KK, Lieberman E, Ryan L, Holmes LB 1998 The prenatal detection of significant alcohol exposure with maternal blood markers. J Pediatr 133:346-352
7. Walsh RA, Redman S, Adamson L 1996 The accuracy of self-report of smoking status in pregnant women. Addict Behav 21:675-679
8. Bearer CF, Gould S, Emerson R, Kinnunen P, Cook CS 1992 Fetal alcohol syndrome and fatty acid ethyl esters. Pediatr Res 31:492-495
9. Soderberg BL, Sicinska ET, Blodget E, Cluette-Brown JE, Suter PM, Schuppisser T, Vetter W, Laposata M 1999 Preanalytical variables affecting the quantification of fatty acid ethyl esters in plasma and serum samples. Clin Chem 45:2183-2190
10. Caprara DL, Brien JF, Iqbal U, Reynolds JN, Klein J, Koren G 2005 A guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair. Pediatr Res 58:1158-1163
11. Bearer CF, Lee S, Salvator AE, Minnes S, Swick A, Yamashita T, Singer LT 1999 Ethyl linoleate in meconium: a biomarker for prenatal ethanol exposure. Alcohol Clin Exp Res 23:487-493
12. Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Molteno CD, Viljoen DL, Marais AS, Chiodo LM, Cwik AS 2003 Validation of a new biomarker of fetal exposure to alcohol. J Pediatr 143:463-469
13. Bearer CF, Santiago LM, O'Riordan MA, Buck K, Lee SC, Singer LT 2005 Fatty acid ethyl esters: quantitative biomarkers for maternal alcohol consumption. J Pediatr 146:824-830
14. Moore C, Jones J, Lewis D, Buchi K 2003 Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 49:133-136
15. Ostrea EM, Hernandez JD, Bielawski DM, Kan JM, Leonardo GM, Abela MB, Church MW, Hannigan JH, Janisse JJ, Ager JW, Sokol RJ 2006 Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect? Alcohol Clin Exp Res 30:1152-1159
16. Cudd TA 2005 Animal model systems for the study of alcohol teratology. Exp Biol Med (Maywood) 230:389-393
17. Dobbing J, Sands J 1979 Comparative aspects of the brain growth spurt. Early Hum Dev 3:79-83
18. Bearer CF 1999 Detection of Teratogen Exposure. U.S. Patent Documents. Case Western Reserve University, Cleveland, OH
19. Abel EL 1996 Fetal Alcohol Syndrome: From Mechanism to Prevention. CRC Press, Inc., Boca Raton, FL
20. Klein J, Karaskov T, Koren G 1999 Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. Ther Drug Monit 21:644-646
21. Moore CM, Lewis D 2001 Fatty acid ethyl esters in meconium: biomarkers for the detection of alcohol exposure in neonates. Clin Chim Acta 312:235-237
22. Brien JF, Chan D, Green CR, Iqbal U, Gareri J, Kobus SM, McLaughlin BE, Klein J, Rao C, Reynolds JN, Bocking AD, Koren G 2006 Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal guinea pig. Ther Drug Monit 28:345-350
23. Kulaga V, Caprara D, Iqbal U, Kapur B, Klein J, Reynolds J, Brien J, Koren G 2006 Fatty acid ethyl esters (FAEE); comparative accumulation in human and guinea pig hair as a biomarker for prenatal alcohol exposure. Alcohol Alcohol 41:534-539
24. Stark KD, Beblo S, Murthy M, Whitty JE, Buda-Abela M, Janisse J, Rockett H, Martier SS, Sokol RJ, Hannigan JH, Salem NJ 2005 Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. Alcohol Clin Exp Res 29:130-140
25. Horrobin DF 1987 Essential fatty acids, prostaglandins, and alcoholism: an overview. Alcohol Clin Exp Res 11:2-9
26. Valles SL, Blanco AM, Pascual M, Guerri C 2004 Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes. Brain Pathol 14:365-371
27. Natsuki R, Yamaguchi T 1996 Effects of ethanol on phospholipases in the mouse brain, heart and liver. Biol Pharm Bull 19:525-529
28. Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M 2002 Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake. Clin Chem 48:77-83
29. Chan D, Bar-Oz B, Pellerin B, Paciorek C, Klein J, Kapur B, Farine D, Koren G 2003 Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit 25:271-278
30. Perez-Camino MC, Moreda W, Mateos R, Cert A 2002 Determination of esters of fatty acids with low molecular weight alcohols in olive oils. J Agric Food Chem 50:4721-4725
31. Ostrovsky YM, Pronko PS, Shishkin SN, Kolesnikov VB, Volynets SI 1989 An attempt to evaluate diagnostic and prognostic significance of blood endogenous ethanol in alcoholics and their relatives. Alcohol 6:97-102
32. Hendrickse W, Stammers JP, Hull D 1985 The transfer of free fatty acids across the human placenta. Br J Obstet Gynaecol 92:945-952
33. Elphick MC, Hull D, Broughton PF 1979 The transfer of fatty acids across the sheep placenta. J Dev Physiol 1:31-45
34. Jarvis GN, Moore ER, Thiele JH 1997 Formate and ethanol are the major products of glycerol fermentation produced by a Klebsiella planticola strain isolated from red deer. J Appl Microbiol 83:164-174