A guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair

Pediatric Research

Volumn 58, Issue 6, 2005, Pages 1158-1163

  Caprara, Daniela L ^a   Brien, James F ^b   Iqbal, Umar ^b   Reynolds, James N ^b   Klein, Julia ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; FATTY ACID ESTER; SUCROSE; WATER; ESTER; FATTY ACID;

ADOLESCENT; ALCOHOL CONSUMPTION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; FETAL ALCOHOL SYNDROME; GUINEA PIG; HAIR ANALYSIS; HAIR LEVEL; HUMAN; HUMAN TISSUE; LONG TERM EXPOSURE; NEWBORN; NONHUMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; FETOMATERNAL TRANSFUSION; HAIR; PREGNANCY; UTERUS;

ANIMALS; DISEASE MODELS, ANIMAL; ESTERS; ETHANOL; FATTY ACIDS; FEMALE; FETAL ALCOHOL SYNDROME; GUINEA PIGS; HAIR; HUMANS; MATERNAL-FETAL EXCHANGE; PREGNANCY; UTERUS;

EID: 33644808825     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000185201.83801.ed     Document Type: Article

References (29)

1. Sampson PD, Streissguth AP, Bookstein FL, Little RE, Clarren SK, Dehaene P, Hanson JW, Graham JM Jr 1997 Incidence of fetal alcohol syndrome and prevalence of alcohol-related neurodevelopmental disorder. Teratology 56:317-326
2. Battaglia FC, Howe CJ, Stratton KR, Institute of Medicine, National Institute on Alcohol Abuse and Alcoholism 1996 Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment. National Academy Press, Washington, DC
3. Ebrahim SH, Diekman ST, Floyd RL, Decoufle P 1999 Comparison of binge drinking among pregnant and nonpregnant women, United States, 1991-1995. Am J Obstet Gynecol 180:1-7
4. Abel EL 1996 Fetal Alcohol Syndrome: From Mechanism to Prevention. CRC Press, Boca Raton, FL
5. Russell M, Martier SS, Sokol RJ, Mudar P, Jacobson S, Jacobson J 1996 Detecting risk drinking during pregnancy: a comparison of four screening questionnaires. Am J Public Health 86:1435-1439
6. Laposata M 1999 Fatty acid ethyl esters: current facts and speculations. Prostaglandins Leukot Essent Fatty Acids 60:313-315
7. Best CA, Laposata M 2003 Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci 8:e202-e217
8. Bearer CF 2001 Markers to detect drinking during pregnancy. Alcohol Res Health 25:210-218
9. Klein J, Karaskov T, Korent G 1999 Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. Ther Drug Monit 21:644-646
10. Ursitti F, Klein J, Koren G 1997 Clinical utilization of the neonatal hair test for cocaine: a four-year experience in Toronto. Biol Neonate 72:345-351
11. Auwarter V, Sporkert F, Hartwig S, Pragst F, Vater H, Diefenbacher A 2001 Fatty acid ethyl esters in hair as markers of alcohol consumption. Segmental hair analysis of alcoholics, social drinkers, and teetotalers. Clin Chem 47:2114-2123
12. Pragst F, Auwaerter V, Sporkert F, Spiegel K 2001 Analysis of fatty acid ethyl esters in hair as possible markers of chronically elevated alcohol consumption by headspace solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC- MS). Forensic Sci Int 121:76-88
13. Clarke DW, Steenaart NA, Slack CJ, Brien JF 1986 Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guinea pig for oral administration of acute, multiple-dose ethanol. Can J Physiol Pharmacol 64:1060-1067
14. Zahlten RN, Nejtek ME, Jacobson JC 1981 Ethanol metabolism in guinea pig: in vivo ethanol elimination, alcohol dehydrogenase distribution, and subcellular localization of acetaldehyde dehydrogenase in liver. Arch Biochem Biophys 207:371-379
15. Reynolds JD, Brien JF 1995 Ethanol neurobehavioural teratogenesis and the role of L-glutamate in the fetal hippocampus. Can J Physiol Pharmacol 73:1209-1223
16. Kimura KA, Parr AM, Brien JF 1996 Effect of chronic maternal ethanol administration on nitric oxide synthase activity in the hippocampus of the mature fetal guinea pig. Alcohol Clin Exp Res 20:948-953
17. Catlin MC, Abdollah S, Brien JF 1993 Dose-dependent effects of prenatal ethanol exposure in the guinea pig. Alcohol 10:109-115
18. Steenaart NA, Clarke DW, Brien JF 1985 Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetaldehyde formation. J Pharmacol Methods 14:199-212
19. Chan D, Bar-Oz B, Pellerin B, Paciorek C, Klein J, Kapur B, Farine D, Koren G 2003 Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit 25:271-278
20. Bernhardt TG, Cannistraro PA, Bird DA, Doyle KM, Laposata M 1996 Purification of fatty acid ethyl esters by solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Appl 675:189-196
21. Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M 2002 Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake. Clin Chem 48:77-83
22. Jennison CPR, Jennison J 1994 The determination of trace level FAMES using CI mode GC/MS. Varian Application Note 37b. Available at http://www.varianinc.com/image/vimage/docs/products/chrom/apps/gcms37.pdf
23. Moore C, Jones J, Lewis D, Buchi K 2003 Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem 49:133-136
24. Chan D, Klein J, Koren G 2004 Validation of meconium fatty acid ethyl esters as biomarkers for prenatal alcohol exposure. J Pediatr 144:692
25. Wurst FM, Alexson S, Wolfersdorf M, Bechtel G, Forster S, Alling C, Aradottir S, Jachau K, Huber P, Allen JP, Auwarter V, Pragst F 2004 Concentration of fatty acid ethyl esters in hair of alcoholics: comparison to other biological state markers and self reported-ethanol intake. Alcohol Alcohol 39:33-38
26. Abel EL (ed) 1982 Fetal Alcohol Syndrome. Animal Studies. CRC Press, Boca Raton, FL
27. Caprara D, Klein J, Koren G 2005 Baseline measures of fatty acid ethyl esters in hair of neonates born to abstaining or mild social drinking mothers. Ther Drug Monit (in press)
28. Chan D, Knie B, Boskovic R, Koren G 2004 Placental handling of fatty acid ethyl esters: perfusion and subcellular studies. J Pharmacol Exp Ther 310:75-82
29. Jansson T, Thordstein M, Kjellmer I 1986 Placental blood flow and fetal weight following uterine artery ligation. Temporal aspects of intrauterine growth retardation in the guinea pig. Biol Neonate 49:172-180