Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal guinea pig

Therapeutic Drug Monitoring

Volumn 28, Issue 3, 2006, Pages 345-350

  Brien, James F ^a   Chan, Daphne ^b   Green, Courtney R ^a   Iqbal, Umar ^a   Gareri, Joey ^b   Kobus, Susan M ^a   McLaughlin, Brian E ^a   Klein, Julia ^b   Rao, Chitra ^b   Reynolds, James N ^a   Bocking, Alan D ^c   Koren, Gideon ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Chronic prenatal ethanol exposure; Fatty acid ethyl esters; Meconium; Term fetal guinea pig

Indexed keywords

ALCOHOL; ARACHIDONIC ACID; BIOLOGICAL MARKER; FATTY ACID ESTER; LAURIC ACID; LINOLEIC ACID; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; STEARIC ACID; SUCROSE; WATER;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BRAIN WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FETUS; FETUS DEVELOPMENT; GAS CHROMATOGRAPHY; GROWTH RETARDATION; GUINEA PIG; LARGE INTESTINE; MASS SPECTROMETRY; MECONIUM; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; VALIDITY;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; BRAIN; ETHANOL; FATTY ACIDS; FEMALE; GUINEA PIGS; MATERNAL EXPOSURE; MECONIUM; ORGAN SIZE; PREGNANCY; PREGNANCY OUTCOME; PRENATAL EXPOSURE DELAYED EFFECTS; SUBSTANCE ABUSE DETECTION;

EID: 33748169223     PISSN: 01634356     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ftd.0000211819.35182.82     Document Type: Article

References (31)

1. Stratton K, Howe C, Battaglia F, (eds). Fetal Alcohol Syndrome: Diagnosis, Epidemiology, Prevention, and Treatment. Washington, DC: National Academy Press; 1996.
2. Sarkola T, Eriksson CJ, Niemela O, et al. Mean cell volume and gamma-glutamyl transferase are superior to carbohydrate-deficient transferrin and hemoglobin-acetaldehyde adducts in the follow-up of pregnant women with alcohol abuse. Acta Obstet Gynecol Scand. 2000;79:359-366.
3. Russell M, Martier SS, Sokol RJ, et al. Detecting risk drinking during pregnancy: a comparison of four screening questionnaires. Am J Public Health. 1996;86:1435-1439.
4. Best CA, Laposata M. Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake. Front Biosci. 2003;8:e202-e217.
5. Laposata M. Fatty acid ethyl esters: nonoxidative ethanol metabolites with emerging biological and clinical significance. Lipids. 1999;34:S281-S285.
6. Laposata EA, Lange LG. Presence of nonoxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science. 1986;231:497-499.
7. Ostrea EM Jr. Testing for exposure to illicit drugs and other agents in the neonate: a review of laboratory methods and the role of meconium analysis. Curr Probl Pediatr. 1999;29:37-56.
8. Ostrea EM Jr, Knapp DK, Tannenbaum L, et al. Estimates of illicit drug use during pregnancy by maternal interview, hair analysis, and meconium analysis. J Pediatr. 2001;138:344-348.
9. Bearer CF, Lee S, Salvator AE, et al. Ethyl linoleate in meconium: a biomarker for prenatal ethanol exposure. Alcohol Clin Exp Res. 1999;23:487-493.
10. Moore C, Jones J, Lewis D, et al. Prevalence of fatty acid ethyl esters in meconium specimens. Clin Chem. 2003;49:133-136.
11. Chan D, Bar-Oz B, Pellerin B, et al. Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto. Ther Drug Monit. 2003;25:271-278.
12. Bearer CF, Jacobson JL, Jacobson SW, et al. Validation of a new biomarker of fetal exposure to alcohol. J Pediatr. 2003;143:463-469.
13. Reynolds JD, Brien JF. Ethanol neurobehavioural teratogenesis and the role of L-glutamate in the fetal hippocampus. Can J Physiol Pharmacol. 1995;73:1209-1223.
14. Kimura KA, Reynolds JN, Brien JF. Ethanol neurobehavioral teratogenesis and the role of the hippocampal glutamate-N-methyl-D-aspartate receptor-nitric oxide synthase system. Neurotoxicol Teratol. 2000;22:607-616.
15. Dobbing J, Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev. 1979;3:79-83.
16. Kimura KA, Parr AM, Brien JF. Effect of chronic maternal ethanol administration on nitric oxide synthase activity in the hippocampus of the mature fetal guinea pig. Alcohol Clin Exp Res. 1996;20:948-953.
17. Butters NS, Gibson MAS, Reynolds JN, et al. Effects of chronic prenatal ethanol exposure on hippocampal glutamate release in the postnatal guinea pig. Alcohol. 2000;21:1-9.
18. A receptor subunit protein expression in the adult guinea pig cerebral cortex. J Neurosci. 2001;21:4381-4389.
19. Richardson DP, Byrnes ML, Brien JF, et al. Impaired acquisition in the water maze and hippocampal long-term potentiation after chronic prenatal ethanol exposure in the guinea-pig. Eur J Neurosci. 2002;16:1593-1598.
20. Hayward ML, Martin AE, Brien JF, et al. Chronic prenatal ethanol exposure impairs conditioned responding and enhances GABA release in the hippocampus of the adult guinea pig. J Pharmacol Exp Ther. 2004;308:644-650.
21. Elvidge H. Production of dated pregnant guinea pigs without post-partum matings. J Inst Anim Technol. 1972;23:111-117.
22. Abdollah S, Catlin MC, Brien JF. Ethanol neuro-behavioural teratogenesis in the guinea pig: behavioural dysfunction and hippocampal morphologic change. Can J Physiol Pharmacol. 1993;71:776-782.
23. Catlin MC, Abdollah S, Brien JF. Dose-dependent effects of prenatal ethanol exposure in the guinea pig. Alcohol. 1993;10:109-115.
24. Clarke DW, Steenaart NAE, Slack CJ, et al. Pharmacokinetics of ethanol and its metabolite, acetaldehyde, and fetolethality in the third-trimester pregnant guinea pig for oral administration of acute multiple-dose ethanol. Can J Physiol Pharmacol. 1986;64:1060-1067.
25. Steenaart NAE, Clarke DW, Brien JF. Gas-liquid chromatographic analysis of ethanol and acetaldehyde in blood with minimal artifactual acetylaldehyde formation. J Pharmacol Methods. 1985;14:199-212.
26. Kimura KA, Brien JF. Hippocampal nitric oxide synthase in the fetal guinea pig: effects of chronic prenatal ethanol exposure. Dev Brain Res. 1998;106:39-46.
27. Abel EL, ed. Fetal Alcohol Syndrome. Vol. II. Human Studies. Boca Raton: CRC Press; 1982.
28. Abel EL, ed. Fetal Alcohol Syndrome. Vol. III. Animal Studies. Boca Raton: CRC Press; 1982.
29. Chan D, Knie B, Boskovic R, et al. Placental handling of fatty acid ethyl esters: perfusion and subcellular studies. J Pharmacol Exp Ther. 2004;310:75-82.
30. Clarke DW, Steenaart NAE, Brien JF. Disposition of ethanol and activity of hepatic and placental alcohol dehydrogenase and aldehyde dehydrogenases in the third-trimester pregnant guinea pig for single and short-term oral ethanol administration. Alcohol Clin Exp Res. 1986;10:330-336.
31. Chan D, Caprara D, Blanchette P, et al. Recent developments in meconium and hair testing methods for the confirmation of gestational exposures to alcohol and tobacco smoke. Clin Biochem. 2004;37:429-438.