SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy

Nucleic Acids Research

Volumn 36, Issue 1, 2008, Pages 263-283

  Park, Mi Ae ^a,b   Seok, Yeong Jae ^b   Jeong, Gajin ^b   Lee, Jong Soo ^a  

^a Ajou University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; HISTONE; RNA; SUMO 1 PROTEIN;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DEACETYLATION; DNA BINDING; DNA DAMAGE; GENE REPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOBLOTTING; MUTANT; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SUMOYLATION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

BINDING SITES; BRCA1 PROTEIN; CELL CYCLE PROTEINS; CELL LINE; DNA DAMAGE; DOWN-REGULATION; HISTONE DEACETYLASES; HISTONES; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; SUMO-1 PROTEIN; TRANS-ACTIVATION (GENETICS); TWO-HYBRID SYSTEM TECHNIQUES;

EID: 38349096713     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkm969     Document Type: Article

References (40)

1. Welcsh,P.L. and King,M.C. (2001) BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum. Mol. Genet., 10, 705-713.
2. Venkitaraman,A.R. (2001) Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J Cell Sci., 114, 3591-3598.
3. Jang,E.R. and Lee,J.-S. (2004) Diverse functions of BRCA1. Cancer Res. Treat., 36, 214-221.
4. Zheng,L., Pan,H., Li,S., Flesken-Nikitin,A., Chen,P.L., Boyer,T.G. and Lee,W.H- (2000) Sequence specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol. Cell, 6, 757-768.
5. Pao,G.M., Janknecht,R., Ruffner,H., Hunter,T. and Verma,I.M. (2000) CBP/ p300 interact with and function as transcriptional coactivators of BRCA1. Proc. Natl Acad. Sci. USA, 97, 1020-1025.
6. Tan,W., Zheng,L., Lee,W.H. and Boyer,T.G. (2004) Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. J. Biol. Chem., 279, 6576-6587.
7. Oishi,H., Kitagawa,H., Wada,O., Takezawa,S., Tora,L., Kouzu-Fujita,M., Takada,I., Yano,T., Yanagisawa,J. and Kato,S. (2006) An hGCN5/TRRAP histone acetyltransferase complex co-activates BRCA1 transactivation function through histone modification. J. Biol. Chem., 281, 20-26.
8. Somasundaram,K., Zhang,H., Zeng,Y.X., Houvras,Y., Peng,Y., Zhang,H., Wu,G.S., Licht,J.D., Weber,B.L. and El-Deiry,W.S. (1997) Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature, 389, 187-190.
9. Ouchi,T., Monteiro,A.N., August,A., Aaronson,S.A. and Hanafusa,H. (1998) BRCA1 regulates p53-dependent gene expression. Proc. Natl Acad. Sci. USA, 95, 2302-2306.
10. Li,S., Ting,N.S., Zheng,L., Chen,P.L., Ziv,Y., Shiloh,Y., Lee,E.Y. and Lee,W.H. (2000) Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature, 406, 210-215.
11. Fan,S., Yuan,R., Ma,Y.X., Yiong,J., Meng,Q., Erdos,M., Zhao,J.N., Goldberg,I.D., Pestell,R.G. and Rosen,E.M. (2001) Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding. Oncogene, 20, 4827-4841.
12. WelcshP.L., Lee,M.K., Gonsalez-Hernandez,R.M., Black,D.J., Mahadevappa,K., Swisher,E.M., Warrington,J.A. and King,M.C (2002) BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc. Natl Acad. Sci. USA, 99, 7560-7565.
13. Yarden,R.I. and Brody,L.C. (1999) BRCA1 interacts with components of the histone deacetylase complex. Proc. Natl Acad. Sci. USA, 96, 4983-4988.
14. Anderson,S.F., Schlegel,B.P., Nakajima,T., Wolpin,E.S. and Parvin,J.D. (1998) BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat. Genet., 19, 254-256.
15. Chai,Y.L., Cui,J., Shao,N., Shyam,E., Reddy,P. and Rao,V.N. (1999) The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. Oncogene, 18, 263-268.
16. Bochar,D.A., Wang,L., Beniya,H., Kinev,A., Xue,Y., Lane,W.S., Wang,W., Kashanchi,F. and Shiekhattar,R. (2000) BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer. Cell, 102, 257-265.
17. Baker,K.M., Wei,G., Schaffner,A.E. and Ostrowski,M.C. (2003) Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter. J. Biol. Chem., 278, 17876-17884.
18. Chinnadurai,G. (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol. Cell, 9, 213-224.
19. Shiio,Y. and Eisenman,R.N. (2003) Histone sumoylation is associated with transcriptional repression. Proc. Natl Acad. Sci. USA, 100, 13225-16230.
20. Yang,S.H. and Sharrocks,A.D. (2004) SUMO promotes HDAC-mediated transcriptional repression. Mol Cell, 13, 611-617.
21. David,G., Neptune,M.A. and DePinho,R.A. (2002) SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J. Biol. Chem., 277, 23658-23663.
22. Girdwood,D., Bumpass,D., Vaughan,O.A., Thain,A., Anderson,L.A., Snowden,A.W., Garcia-Wilson,E., Perkins,N.D. and Hay,R.T. (2003) P300 transcriptional repression is mediated by SUMO modification. Mol. Cell, 11, 1043-1054.
23. Lin,X., Sun,B., Liang,M., Liang,Y.Y., Gast,A., Hildebrand,J., Brunicardi,F.C., Melchior,F. and Feng,X.H. (2003) Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding. Mol. Cell, 11 1389-1396.
24. Rogers,R.S., Horvath,C.M. and Matunis,M.J. (2003) SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. J. Biol. Chem., 278, 30091-30097.
25. Perdomo,J., Verger,A., Turner,J. and Crossley,M. (2005) Role for SUMO modification in facilitating transcriptional repression by BKLF. Mol Cell Biol., 25, 1549-1559.
26. Scully,R., Ganesan,S., Brown,M., De Caprio,J.A., Cannistra,S.A., Feunteun,J., Schnitt,S. and Livingston,D.M. (1996) Location of BRCA1 in human breast and ovarian cancer cells. Science, 272, 123-126.
27. Lee,J.-S., Collins,K.M., Brown,A.L., Lee,C.H. and Chung,J.H. (2000) hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature, 404, 201-204.
28. Brummelkamp,T.R., Bernards,R. and Agami,R. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
29. Fan,W., Jin,S., Tong,T., Zhao,H., Fan,F., Antinore,M.J., Rajasekaran,B., Wu,M. and Zhan,Q. (2002) BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. J. Biol. Chem., 277, 8061-8067.
30. Hilgarth,R.S., Murphy,L.A., Skaggs,H.S., Wilkerson,D.C., Ying,H. and Sarge,K.D. (2004) Regulation and function of SUMO modification. J. Biol. Chem., 52, 53899-53902.
31. Minty,A., Dumont,X., Kaghad,M. and Caput,D. (2000) Covalent modification of p73α by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J. Biol. Chem., 275, 36316-36323.
32. Hannich,J.T., Lewis,A., Kroetz,M.B, Li,S., Jeide,H., Emili,A. and Hochstrasser,M. (2005) Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J. Biol. Chem., 280, 4102-4110.
33. Reverter,D. and Lima,C.D. (2005) Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature, 435, 697-692.
34. Shen,T.H., Lin,H.K., Scaglioni,P.P., Yung,T.M. and Pandolfi,P.P. (2006) The mechanisms of PML-nuclear body formation. Mol. Cell, 24, 331-339.
35. Kip1. Oncogene 25, 1391-1399.
36. WAF1/CIP1 expression. J. Biol. Chem., 281, 21119-21130.
37. Li,W., Hesabi,B., Babbo,A.; Pacione,C., Liu,J., Chen,D.J., Nickoloff,J.A. and Shen,Z. (2000) Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein. Nucleic Acids Res., 28, 1145-1153.
38. Lee,Y.S., Jang,M.S., Lee,J.-S. and Kim,E. (2005) SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification. EMBO Rep., 6 949-955.
39. Zheng,Z., Cai,C., Omwancha,C., Chen,S.Y., Baslan,T. and Shemshedini,L. (2006) SUMO-3 enhances androgen receptor transcriptional activity through a sumoylation-independent mechanism in prostate cancer cells. J. Biol. Chem., 281, 4002-4012.
40. Thompson,M.E., Jensen,R.A., Obermiller,P.S., Page,D.L. and Hott,J.T. (1995) Decreased expression of BRCA1 acceletates growth and is often present during sporadic breast cancer progression. Nat. Genet., 9, 444-450.