A quantitative study of growth variability of tumour cell clones in vitro

Cell Proliferation

Volumn 41, Issue 1, 2008, Pages 177-191

  Tomelleri, C ^a   Milotti, E ^b,c   Dalla Pellegrina, C ^a   Perbellini, O ^a   Del Fabbro, A ^b,c   Scupoli, M T ^a   Chignola, R ^a,c  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c SEZIONE DI TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CELL CLONING; CELL COUNT; CELL CYCLE; CELL GROWTH; CELL POPULATION; CONTROLLED STUDY; EXPERIMENTAL STUDY; FLOW CYTOMETRY; GROWTH RATE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; MITOCHONDRION; SPECTROPHOTOMETRY; TUMOR CELL;

BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; CLONE CELLS; DNA PRIMERS; FLOW CYTOMETRY; HUMANS; LEUKEMIA; MITOCHONDRIA; SPECTROPHOTOMETRY;

EID: 38349090477     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2007.00501.x     Document Type: Article

References (27)

1. Armand R, Channon JY, Kintner J, White KA, Miselis KA, Perez RP, Lewis LD (2004) The effects of ethidium bromide induced loss of mitochondrial DNA on mitochondrial phenotype and ultrastructure in a human leukemia T-cell line (MOLT-4 cells). Toxicol. Appl. Pharmacol. 196, 68 79.
2. Barcellos-Hoff MH (2001) It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J. Mammary Gland Biol. Neoplasia 6, 213 221.
3. Beckman RA, Loeb LA (2005) Genetic instability in cancer; theory and experiment. Semin. Cancer Biol. 15, 423 435.
4. Birky CW Jr. (1983) The partitioning of cytoplasmic organelles at cell division. Int. Rev. Cytol. Suppl. 15, 49 89.
5. Chignola R, Foroni R, Franceschi A, Pasti M, Candiani C, Anselmi C, Fracasso G, Tridente G, Colombatti M (1995) Heterogeneous response of individual multicellular tumour spheroids to immunotoxins and ricin toxin. Br. J. Cancer 72, 607 614.
6. Chignola R, Dai Pra P, Morato LM, Siri P (2006) Proliferation and death in a binary environment: a stochastic model of cellular ecosystems. Bull. Math. Biol. 68, 1661 1680.
7. Chignola R, Schenetti A, Chiesa E, Foroni R, Sartoris S, Brendolan A, Tridente G, Andrighetto G, Liberati D (1999) Oscillating growth pattern of multicellular tumour spheroids. Cell Prolif. 32, 39 48.
8. Chiorino G, Metz JAJ, Tomasoni D, Ubezio P (2001) Desynchronization rate in cell populations: mathematical modeling and experimental data. J. Theor. Biol. 208, 185 199.
9. Deisboeck TS, Berens ME, Kansal AR, Torquato S, Stemmer-Rachamimov AO, Chiocca EA (2001) Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model. Cell Prolif. 34, 115 134.
10. Fidler IJ (2002) The organ microenvironment and cancer metastasis. Differentiation 70, 498 505.
11. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100, 57 50.
12. Holmuhamedov E, Lewis L, Bienengraeber M, Holmuhamedova M, Jahangir A, Terzic A (2002) Suppression of human tumor cell proliferation through mitochondrial targeting. FASEB J. 16, 1010 1016.
13. James TW, Bohman R (1981) Proliferation of mitochondria during the cell cycle of the human cell line (HL-60). J. Cell Biol. 89, 256 260.
14. Kendal WS, Frost P (1986) Metastatic potential and spontaneous mutation rates: studies with two murine cell lines and their recently induced metastatic variants. Cancer Res. 46, 6131 6135.
15. Laird AK (1969) Dynamics of growth in tumours and normal organisms. Natl. Cancer Inst. Monogr. 30, 15 28.
16. Lefkovits I, Waldmann H (1979) Limiting Dilution Analysis of Cells in the Immune System. Cambridge, UK : Cambridge University Press.
17. Luria SE, Delbrück M (1943) Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28, 491 511.
18. McAdams HH, Arkin A (1999) It's a noisy business! Genetic regulation at the nanomolar scale. Trends Genet. 15, 65 69.
19. Nguyen DX, Massagué J (2007) Genetic determinants of cancer metastasis. Nat. Rev. Genet. 8, 341 351.
20. Norton L (1985) Implications of kinetic heterogeneity in clinical oncology. Semin. Oncol. 12, 231 249.
21. Posakony JW, England JM, Attardi G (1977) Mitochondrial growth and division during the cell cycle in HeLa cells. J. Cell Biol. 74, 468 491.
22. Robin ED, Wong R (1988) Mitochondrial DNA molecules and virtual number of mitochondria per cell in mammalian cells. J. Cell. Physiol. 136, 507 513.
23. Rubin H (2005) Degrees and kinds of selection in spontaneous neoplastic transformation: an operational analysis. Proc. Natl. Acad. Sci. USA 102, 9276 9281.
24. Rudd CJ, Daston DS, Caspary WJ (1990) Spontaneous mutation rates in mammalian cells: effect of differential growth rates and phenotypic lag. Genetics 126, 435 442.
25. Vineis P (2003) Cancer as an evolutionary process at the cell level: an epidemiological perspective. Carcinogenesis 24, 1 6.
26. Weinberg RA (1989) Oncogenese, antioncogenes, and the molecular basis of multistep carcinogenesis. Cancer Res. 49, 3713 3721.
27. Wilson GD (2001) A new look at proliferation. Acta Oncol. 40, 989 994.