Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice (Archives of Toxicology DOI 10.1007/s00204-007-0222-5);Toxicity and carcinogenicity studies of 4-methylimidazole in F344/N rats and B6C3F1 mice

Archives of Toxicology

Volumn 82, Issue 1, 2008, Pages 45-53

  Chan, P C ^a   Hills, G D ^b   Kissling, G E ^a   Nyska, A ^c  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

4 Methylimidazole; Carcinogenicity; Mice; Rats; Toxicity

Indexed keywords

4 METHYLIMIDAZOLE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALCULATION; CARCINOGENICITY; CHRONIC INFLAMMATION; CLONIC SEIZURE; CONTROLLED STUDY; DIETARY INTAKE; EOSINOPHILIA; EPITHELIUM HYPERPLASIA; EXCITABILITY; FEMALE; FOOD INTAKE; GAIT DISORDER; HISTIOCYTOSIS; HYPERACTIVITY; LEUKEMIA; LUNG ADENOMA; LUNG ALVEOLUS; LUNG ALVEOLUS CELL CARCINOMA; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOMA; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

MUS; NICOTIANA TABACUM; RATTUS;

EID: 38349083847     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0227-0     Document Type: Erratum

References (38)

1. Bailer AJ, Portier CJ (1988) Effects of treatment-induced mortality and tumor-induced mortality on tests for carcinogenicity in small samples. Biometrics 44:417-431
2. Bergman U, Brittebo EB (1999) Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb. Toxicol Appl Pharmacol 155:190-200
3. Chan P, Mahler J, Travlos G, Nyska A, Wenk M (2006) Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice. Arch Toxicol 80:168-180
4. Chappel CI, Howell JC (1992) Caramel colours-a historical introduction. Food Chem Toxicol 30:351-357
5. Chemical Economic Handbook (1995) Online. Dialog. 359. Bibliographic database
6. Chemical Dynamics, Corp. (1989) The 1989-90 Chemalog. In: Catalog/handbook of biochemicals, organic chemicals and inorganic chemicals. Chemical Dynamics, Corp., South Plainfield, NJ
7. Cox DR (1972) Regression models and life-tables. J R Stat Soc B34:187-220
8. Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SC, Obach RS, O'Donnell JP (2002) Biotransformation reactions of five-membered aromatic heterocyclic rings. Chem Res Toxicol 15:269-299
9. Fairbrother TE, Kerr LA, Essig HW (1987) Effects of 4-methylimiazole in young calves. Vet Hum Toxicol 29:312-315
10. Genter MB, Deamer NJ, Blake BL, Wesley DS, Levi PE (1995) Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin- containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicol Pathol 23:477-486
11. Haseman JK, Young E, Eustis SL, Hailey JR (1997) Body weight-tumor incidence correlations in long-term rodent carcinogenicity studies. Toxicol Pathol 25:256-263
12. Hollander M, Wolfe DA (1973) Nonparametric statistical methods. Wiley, New York, pp 120-123
13. Huang Y, Zhang S, Yang R (1983) Survey of communal industrial production of caramel by the ammonium process. Tiaowei Fushipin Keji 3:11-12 (Abstract)
14. Jeffry AM, Iatropoulos MJ, Williams GM (2006) Nasal cytotoxic and carcinogenic activities of systemically distributed organic chemicals. Toxicol Pathol 34:827-852
15. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
16. MacKenzie KM, Boysen BG, Field WE, Petsel SR, Chappel CI, Emerson JL, Stanley J (1992) Toxicity and carcinogenicity studies of Caramel Colour IV in F344 rats and B6C3F1 mice. Food Chem Toxicol 30:431-443
17. Mattyasovszky P, Jeszenszky Z (1985) Determination of caramels in wines by gel chromatography and gas chromatography. Borgazdasag 33:105-110 (Abstract)
18. Moree-Testa P, Saint-Jalm Y, Testa A (1984) Identification and determination of imidazole derivatives in cigarette smoke. J Chromatogr 290:263-274
19. Morgan SE, Edwards WC (1986a) Bovine bonkers: new terminology for an old problem. A review of toxicity associated with ammoniated feeds. Vet Hum Toxicol 28:240-242
20. Morgan SE, Edwards WC (1986b) Pilot studies in cattle and mice to determine the presence of 4-methylimidazole in milk after oral ingestion. Vet Hum Toxicol 28:240-242
21. National Toxicology Program (NTP) (2004a) Toxicity studies of 2- and 4-methylimidazole (CAS Nos. 693-98-1 and 822-36-6) administered in feed to F344/N rats and B6C3F1 mice. Toxicity report series No. 67. NIH Publication No. 04-4409. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC
22. National Toxicology Program (NTP) (2004b) NTP technical report on the toxicology and carcinogenesis studies of 2-methylimidazole (CAS No. 693-98-1) in F344/N rats and B6C3F1 mice (feed studies). Technical report series no. 516. NIH Publication No. 05-4456. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC
23. National Toxicology Program (NTP) (2006) NTP technical report on the toxicology and carcinogenesis studies of 4-mmethylimidazole (CAS No. 822-36-6) in F344/N rats and B6C3F1 mice (feed studies). Technical report series No. 535. NIH Publication No. 05- 4471. U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC
24. Nielsen P, Friis C, Kraul I, Olsen CE (1993) Disposition of 4-methylimidazole in goats and heifers. Res Vet Sci 54:72-79
25. Nishie K, Waiss AC Jr, Keyl AC (1969) Toxicity of methylimidazoles. Toxicol Appl Pharmacol 14:301-307
26. Nishie K, Waiss AC Jr, Keyl AC (1970) Pharmacology of alkyl and hydroxyalkylpyrazines. Toxicol Appl Pharmacol 17:244-249
27. Perdok HB, Leng RA (1987) Hyperexcitability in cattle fed ammoniated roughages. Anim Feed Sci Technol 17:121-143
28. Piegorsch WW, Bailer AJ (1997) Statistics for environmental biology and toxicology, Sect. 6.3.2. Chapman and Hall, London
29. Portier J, Bailer AJ (1989) Testing for increased carcinogenicity using a survival- adjusted quantal response test. Fundam Appl Toxicol 12:731-737
30. Ray C, Raisor MJ, Herd DB, Murphy MJ, Reagor JC (1984) Methylimidazole content of ammoniated forages associated with toxicity in cattle. In: American Association of Veterinary Laboratory Diagnosticians 27th Annual Proceedings, pp 337-348
31. Sakuma H, Kusama M, Yamaguchi K, Matsuki T, Sugawara S (1984) The distribution of cigarette smoke components between mainstream and sidestream smoke. II. Bases. Beitr. Tabakforsch Int 22:199-209 (Abstract)
32. Sanders JM, Griffin RJ, Burka LT, Matthews HB (1998) Disposition of 2- methylimidazole in rats. J Toxicol Environ Health A 54:121-132
33. Tarone RE (1975) Tests for trend in life table analysis. Biometrika 62:679-682
34. Tierney WJ (1979) A four-week dose range-finding study of caramel colour no. 3, sample 3-1, in mice (1987). Cited in WHO Food Additive Series 20, the 29th meeting of the Joint FAO/WHO expert committee on food additives. p 147
35. Weiss WP, Conrad HR, Martin CM, Cross RF, Shockey WL (1986) Etiology of ammoniated hay toxicosis. J Anim Sci 63:525-532
36. Wiggins LF (1956) Some recent studies on ammoniated molasses. Sugar J 18:18-20
37. Wong J, Bernhard RA (1988) Effect of nitrogen source on pyrazine formation. J Agric Food Chem 36:123-129
38. Yoshikawa S, Fujiwara M (1981) Determination of 4(5)-methylimidazole in food by thin layer chromatography. J Food Hyg Soc Jpn 22:189-196 (Abstract)